Literature DB >> 26169074

Public health implications of a North American publicly funded in vitro fertilization program; lessons to learn.

Talya Shaulov1, Serge Belisle2, Michael H Dahan3.   

Abstract

PURPOSE: A retrospective study was conducted to determine trends in practice and outcomes that occurred since the implementation of the publicly funded in vitro fertilization (IVF) and single embryo transfer (SET) program in Quebec, in August, 2010.
METHODS: Data presented was extracted from an advisory report by the Health and Welfare Commissioner, and from a report by the Ministry of Health and Social Services published in June 2014 and October 2013, respectively. This data is publicly available, and was collected from all six private and three public-assisted reproduction centers in Quebec providing IVF services. Data pertains to all IVF cycles performed from the 2009-2010 to 2012-2013 fiscal years.
RESULTS: SET was performed in 71 % of cycles in 2012. The number of children born from IVF was 1057 in 2009-2010 and 1723 in 2012-2013 (p < 0.0001). Multiple birth rates from IVF were 24 % in 2009-2010 (before the program began) and 9.45 % in 2012-2013 (p < 0.0001). The proportions of IVF babies that were premature, that were the result of multiple births, or that required neonatal intensive care unit admission (NICU) all decreased by 35.5 % (p < 0.0001), 55 % (p < 0.0001), and 37 % (p < 0.0001), respectively, from 2009-2010 to 2012-2013. The cost per NICU admission for an IVF baby increased from $19,990 to $28,418 from 2009-2010 to 2011-2012.
CONCLUSION: This first North American publicly funded IVF program with a SET policy shows that such a program contributes substantially to number of births. It has also succeeded in increasing access to treatment and decreasing perinatal morbidity by decreasing multiple birth rates from IVF. A substantial increase in global public health care costs occurred as well.

Entities:  

Keywords:  In vitro fertilization; Neonatal outcomes; Public funding; Single embryo transfer

Mesh:

Year:  2015        PMID: 26169074      PMCID: PMC4595392          DOI: 10.1007/s10815-015-0530-2

Source DB:  PubMed          Journal:  J Assist Reprod Genet        ISSN: 1058-0468            Impact factor:   3.412


  38 in total

Review 1.  Time-lapse monitoring as a tool for clinical embryo assessment.

Authors:  Kirstine Kirkegaard; Inge E Agerholm; Hans Jakob Ingerslev
Journal:  Hum Reprod       Date:  2012-03-14       Impact factor: 6.918

2.  Adverse maternal outcomes in multifetal pregnancies.

Authors:  Mark C Walker; Kellie E Murphy; Saiyi Pan; Qiuying Yang; Shi Wu Wen
Journal:  BJOG       Date:  2004-11       Impact factor: 6.531

Review 3.  Prematurity and twinning.

Authors:  Mario Giuffrè; Ettore Piro; Giovanni Corsello
Journal:  J Matern Fetal Neonatal Med       Date:  2012-10

Review 4.  Obstetric and perinatal outcomes in singleton pregnancies resulting from IVF/ICSI: a systematic review and meta-analysis.

Authors:  Shilpi Pandey; Ashalatha Shetty; Mark Hamilton; Siladitya Bhattacharya; Abha Maheshwari
Journal:  Hum Reprod Update       Date:  2012-05-19       Impact factor: 15.610

5.  Five-years of a mandatory single-embryo transfer (mSET) policy dramatically reduces twinning rate without lowering pregnancy rates.

Authors:  Jessica D Kresowik; Barbara J Stegmann; Amy E Sparks; Ginny L Ryan; Bradley J van Voorhis
Journal:  Fertil Steril       Date:  2011-09-29       Impact factor: 7.329

6.  Adverse obstetric and perinatal outcomes of singleton pregnancies may be related to maternal factors associated with infertility rather than the type of assisted reproductive technology procedure used.

Authors:  Masako Hayashi; Akihito Nakai; Shoji Satoh; Yoshio Matsuda
Journal:  Fertil Steril       Date:  2012-07-02       Impact factor: 7.329

Review 7.  Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis.

Authors:  A Pinborg; U B Wennerholm; L B Romundstad; A Loft; K Aittomaki; V Söderström-Anttila; K G Nygren; J Hazekamp; C Bergh
Journal:  Hum Reprod Update       Date:  2012-11-14       Impact factor: 15.610

Review 8.  Low birth weight: is it related to assisted reproductive technology or underlying infertility?

Authors:  Laxmi A Kondapalli; Alfredo Perales-Puchalt
Journal:  Fertil Steril       Date:  2013-02       Impact factor: 7.329

Review 9.  Number of embryos for transfer following in vitro fertilisation or intra-cytoplasmic sperm injection.

Authors:  Zabeena Pandian; Jane Marjoribanks; Ozkan Ozturk; Gamal Serour; Siladitya Bhattacharya
Journal:  Cochrane Database Syst Rev       Date:  2013-07-29

10.  Factors affecting success rates in two concurrent clinical IVF trials: an examination of potential explanations for the difference in pregnancy rates between the United States and Europe.

Authors:  Valerie L Baker; Clarence E Jones; Barbara Cometti; Fred Hoehler; Bruno Salle; János Urbancsek; Michael R Soules
Journal:  Fertil Steril       Date:  2009-10-07       Impact factor: 7.329

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  2 in total

1.  Outcomes of Preimplantation Genetic Testing for Single Gene Defects in a Privately Funded Period and Publicly Funded Period: A North-American Single Center Experience.

Authors:  Talya Shaulov; Li Zhang; Jin-Tae Chung; Weon-Young Son; William Buckett; Asangla Ao
Journal:  J Reprod Infertil       Date:  2020 Apr-Jun

Review 2.  Promoting the use of elective single embryo transfer in clinical practice.

Authors:  Tamara Tobias; Fady I Sharara; Jason M Franasiak; Patrick W Heiser; Emily Pinckney-Clark
Journal:  Fertil Res Pract       Date:  2016-08-15
  2 in total

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