Tharikarn Sujirakul1, Michael K Lin2, Jimmy Duong3, Ying Wei3, Sara Lopez-Pintado3, Stephen H Tsang4. 1. Bernard & Shirlee Brown Glaucoma Laboratory and Barbara & Donald Jonas Stem Cell Laboratory, Department of Ophthalmology, Columbia University, New York, New York; Department of Ophthalmology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. 2. College of Physicians & Surgeons, Columbia University, New York, New York. 3. Department of Biostatistics, Columbia University, New York, New York. 4. Bernard & Shirlee Brown Glaucoma Laboratory and Barbara & Donald Jonas Stem Cell Laboratory, Department of Ophthalmology, Columbia University, New York, New York; Department of Pathology and Cell Biology and Institute of Human Nutrition, Columbia University, New York, New York. Electronic address: sht2@columbia.edu.
Abstract
PURPOSE: To determine the rate of progression and optimal follow-up time in patients with advanced-stage retinitis pigmentosa (RP) comparing the use of fundus autofluorescence imaging and spectral-domain optical coherence tomography. DESIGN: Retrospective analysis of progression rate. METHODS: Longitudinal imaging follow-up in 71 patients with retinitis pigmentosa was studied using the main outcome measurements of hyperautofluoresent ring horizontal diameter and vertical diameter along with ellipsoid zone line width from spectral-domain optical coherence tomography. Test-retest reliability and the rate of progression were calculated. The interaction between the progression rates was tested for sex, age, mode of inheritance, and baseline measurement size. Symmetry of left and right eye progression rate was also tested. RESULTS: Significant progression was observed in >75% of patients during the 2-year mean follow-up. The mean annual progression rates of ellipsoid zone line and hyperautofluorescent ring horizontal diameter and vertical diameter were 0.45 degree (4.9%), 0.51 degree (4.1%), and 0.42 degree (4.0%), respectively. The ellipsoid zone line width and hyperautofluorescent ring horizontal diameter and vertical diameter had low test-retest variabilities of 8.9%, 9.5%, and 9.6%, respectively. This study is the first to demonstrate asymmetrical structural progression rate between right and left eye, which was found in 19% of patients. The rate of progression was significantly slower as the disease approached the fovea, supporting the theory that RP progresses in an exponential fashion. No significant interaction between progression rate and patient age, sex, or mode of inheritance was observed. CONCLUSIONS: Fundus autofluorescence and optical coherence tomography detect progression in patients with RP reliably and with strong correlation. These parameters may be useful alongside functional assessments as the outcome measurements for future therapeutic trials. Follow-up at 1-year intervals should be adequate to efficiently detect progression.
PURPOSE: To determine the rate of progression and optimal follow-up time in patients with advanced-stage retinitis pigmentosa (RP) comparing the use of fundus autofluorescence imaging and spectral-domain optical coherence tomography. DESIGN: Retrospective analysis of progression rate. METHODS: Longitudinal imaging follow-up in 71 patients with retinitis pigmentosa was studied using the main outcome measurements of hyperautofluoresent ring horizontal diameter and vertical diameter along with ellipsoid zone line width from spectral-domain optical coherence tomography. Test-retest reliability and the rate of progression were calculated. The interaction between the progression rates was tested for sex, age, mode of inheritance, and baseline measurement size. Symmetry of left and right eye progression rate was also tested. RESULTS: Significant progression was observed in >75% of patients during the 2-year mean follow-up. The mean annual progression rates of ellipsoid zone line and hyperautofluorescent ring horizontal diameter and vertical diameter were 0.45 degree (4.9%), 0.51 degree (4.1%), and 0.42 degree (4.0%), respectively. The ellipsoid zone line width and hyperautofluorescent ring horizontal diameter and vertical diameter had low test-retest variabilities of 8.9%, 9.5%, and 9.6%, respectively. This study is the first to demonstrate asymmetrical structural progression rate between right and left eye, which was found in 19% of patients. The rate of progression was significantly slower as the disease approached the fovea, supporting the theory that RP progresses in an exponential fashion. No significant interaction between progression rate and patient age, sex, or mode of inheritance was observed. CONCLUSIONS: Fundus autofluorescence and optical coherence tomography detect progression in patients with RP reliably and with strong correlation. These parameters may be useful alongside functional assessments as the outcome measurements for future therapeutic trials. Follow-up at 1-year intervals should be adequate to efficiently detect progression.
Authors: Luiz H Lima; Tomas Burke; Vivienne C Greenstein; Chai Lin Chou; Wener Cella; Lawrence A Yannuzzi; Stephen H Tsang Journal: Am J Ophthalmol Date: 2011-12-03 Impact factor: 5.258
Authors: Anthony G Robson; Eva Lenassi; Zubin Saihan; Vy A Luong; Fred W Fitzke; Graham E Holder; Andrew R Webster Journal: Invest Ophthalmol Vis Sci Date: 2012-09-14 Impact factor: 4.799
Authors: Eliot L Berson; Bernard Rosner; Carol Weigel-DiFranco; Thaddeus P Dryja; Michael A Sandberg Journal: Invest Ophthalmol Vis Sci Date: 2002-09 Impact factor: 4.799
Authors: Eva Lenassi; Zubin Saihan; Valentina Cipriani; Polona Le Quesne Stabej; Anthony T Moore; Linda M Luxon; Maria Bitner-Glindzicz; Andrew R Webster Journal: Ophthalmology Date: 2013-11-05 Impact factor: 12.079
Authors: Michael A Sandberg; Bernard Rosner; Carol Weigel-DiFranco; Terri L McGee; Thaddeus P Dryja; Eliot L Berson Journal: Invest Ophthalmol Vis Sci Date: 2008-07-18 Impact factor: 4.799
Authors: Alessandro Iannaccone; Stephen B Kritchevsky; Maria Laura Ciccarelli; Salvatore A Tedesco; Claudio Macaluso; William J Kimberling; Grant W Somes Journal: Invest Ophthalmol Vis Sci Date: 2004-03 Impact factor: 4.799
Authors: Anthony G Robson; Michel Michaelides; Zubin Saihan; Alan C Bird; Andrew R Webster; Anthony T Moore; Fred W Fitzke; Graham E Holder Journal: Doc Ophthalmol Date: 2007-11-06 Impact factor: 2.379
Authors: Vitor K L Takahashi; Júlia T Takiuti; Ruben Jauregui; Christine L Xu; Jimmy K Duong; Luiz H Lima; Stephen H Tsang Journal: Graefes Arch Clin Exp Ophthalmol Date: 2019-05-02 Impact factor: 3.117
Authors: Janet R Sparrow; Tobias Duncker; Kaspar Schuerch; Maarjaliis Paavo; Jose Ronaldo Lima de Carvalho Journal: Prog Retin Eye Res Date: 2019-08-28 Impact factor: 21.198
Authors: Ruben Jauregui; Karen Sophia Park; Jimmy K Duong; Janet R Sparrow; Stephen H Tsang Journal: Am J Ophthalmol Date: 2018-07-24 Impact factor: 5.258
Authors: Amir H Hariri; Hong Yang Zhang; Alexander Ho; Peter Francis; Richard G Weleber; David G Birch; Frederick L Ferris; SriniVas R Sadda Journal: JAMA Ophthalmol Date: 2016-06-01 Impact factor: 7.389
Authors: Kyle D Kovacs; Samir Patel; Anton Orlin; Keunpyo Kim; Sherri Van Everen; Therese Conner; Dolan Sondhi; Stephen M Kaminsky; Donald J D'Amico; Ronald G Crystal; Szilárd Kiss Journal: Ophthalmol Retina Date: 2020-01-22
Authors: Jason Charng; Artur V Cideciyan; Samuel G Jacobson; Alexander Sumaroka; Sharon B Schwartz; Malgorzata Swider; Alejandro J Roman; Rebecca Sheplock; Manisha Anand; Marc C Peden; Hemant Khanna; Elise Heon; Alan F Wright; Anand Swaroop Journal: Hum Mol Genet Date: 2016-12-15 Impact factor: 6.150
Authors: Benjamin Otte; Chris Andrews; Gabrielle Lacy; Kari Branham; David C Musch; Kanishka T Jayasundera Journal: Ophthalmic Genet Date: 2021-01-06 Impact factor: 1.803
Authors: Francesco Testa; Andrea Sodi; Sabrina Signorini; Valentina Di Iorio; Vittoria Murro; Raffaella Brunetti-Pierri; Enza Maria Valente; Marianthi Karali; Paolo Melillo; Sandro Banfi; Francesca Simonelli Journal: Invest Ophthalmol Vis Sci Date: 2021-07-01 Impact factor: 4.799