Vitor K L Takahashi1,2,3, Júlia T Takiuti1,2,4, Ruben Jauregui1,2,5, Christine L Xu1,2, Jimmy K Duong6, Luiz H Lima3, Stephen H Tsang7,8,9,10. 1. Department of Ophthalmology, Columbia University, New York, NY, USA. 2. Jonas Children's Vision Care and Bernard and Shirlee Brown Glaucoma Laboratory, New York, USA. 3. Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil. 4. Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil. 5. Weill Cornell Medical College, New York, USA. 6. Department of Biostatistics, Columbia University, New York, NY, USA. 7. Department of Ophthalmology, Columbia University, New York, NY, USA. sht2@cumc.columbia.edu. 8. Jonas Children's Vision Care and Bernard and Shirlee Brown Glaucoma Laboratory, New York, USA. sht2@cumc.columbia.edu. 9. Department of Pathology and Cell Biology, Stem Cell Initiative (CSCI), Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY, USA. sht2@cumc.columbia.edu. 10. Harkness Eye Institute, Columbia University Medical Center, 635 West 165th Street, Box 212, New York, NY, 10032, USA. sht2@cumc.columbia.edu.
Abstract
OBJECTIVE: To evaluate and compare the B-scan OCT loss of ellipsoid zone, OCT en face thickness map constriction, and hyperautofluorescent ring constriction in RP patients. METHODS: Retrospective case series study. Forty-eight eyes of 24 RP patients with a parafoveal hyperautofluorescent ring were studied. The diagnosis of RP was established by the presence of rod response impairment and a prevalent decrease of scotopic over photopic responses on electroretinography. The FAF and spectral-domain optical coherence tomography (SD-OCT) images were obtained from 24 patients with RP. The measurements of the EZ line width on B-scan OCT, hyperautofluorescent ring area on FAF, and hyperautofluorescent ring area on en face thickness map were performed by two independent graders. The measurements of these three parameters were correlated. RESULTS: The mean age of study patients was 46 years old (sd = 19). The external and internal FAF rings involving the fovea were identified in all study eyes. The area of the thickness ring decreased at an average rate of 0.5 (sd 0.4) mm2 per year (P < 0.001). The average rate of EZ-line constriction was estimated to be 123 (sd 63) μm per year (P < 0.001). The hyperautofluorescent ring area decreased at an average rate of 0.9 (sd 0.98) mm2 per year (P < 0.001). The strongest correlation was observed between hyperautofluorescent ring area and EZ-line width (r = 0.78). CONCLUSIONS: We observed that the hyperautofluorescent ring area exhibits a faster progression rate than the area of the thickness ring. In addition, we found that the EZ-line width had a high positive correlation with the hyperautofluorescent ring area and a moderate positive correlation with area of the thickness ring.
OBJECTIVE: To evaluate and compare the B-scan OCT loss of ellipsoid zone, OCT en face thickness map constriction, and hyperautofluorescent ring constriction in RP patients. METHODS: Retrospective case series study. Forty-eight eyes of 24 RP patients with a parafoveal hyperautofluorescent ring were studied. The diagnosis of RP was established by the presence of rod response impairment and a prevalent decrease of scotopic over photopic responses on electroretinography. The FAF and spectral-domain optical coherence tomography (SD-OCT) images were obtained from 24 patients with RP. The measurements of the EZ line width on B-scan OCT, hyperautofluorescent ring area on FAF, and hyperautofluorescent ring area on en face thickness map were performed by two independent graders. The measurements of these three parameters were correlated. RESULTS: The mean age of study patients was 46 years old (sd = 19). The external and internal FAF rings involving the fovea were identified in all study eyes. The area of the thickness ring decreased at an average rate of 0.5 (sd 0.4) mm2 per year (P < 0.001). The average rate of EZ-line constriction was estimated to be 123 (sd 63) μm per year (P < 0.001). The hyperautofluorescent ring area decreased at an average rate of 0.9 (sd 0.98) mm2 per year (P < 0.001). The strongest correlation was observed between hyperautofluorescent ring area and EZ-line width (r = 0.78). CONCLUSIONS: We observed that the hyperautofluorescent ring area exhibits a faster progression rate than the area of the thickness ring. In addition, we found that the EZ-line width had a high positive correlation with the hyperautofluorescent ring area and a moderate positive correlation with area of the thickness ring.
Authors: Mirjam E J van Velthoven; Dirk J Faber; Frank D Verbraak; Ton G van Leeuwen; Marc D de Smet Journal: Prog Retin Eye Res Date: 2006-12-08 Impact factor: 21.198
Authors: Q Li; A M Timmers; K Hunter; C Gonzalez-Pola; A S Lewin; D H Reitze; W W Hauswirth Journal: Invest Ophthalmol Vis Sci Date: 2001-11 Impact factor: 4.799
Authors: Nalini V Rangaswamy; Hemaxi M Patel; Kirsten G Locke; Donald C Hood; David G Birch Journal: Invest Ophthalmol Vis Sci Date: 2010-03-10 Impact factor: 4.799
Authors: Allen C Ho; Mark S Humayun; Jessy D Dorn; Lyndon da Cruz; Gislin Dagnelie; James Handa; Pierre-Olivier Barale; José-Alain Sahel; Paulo E Stanga; Farhad Hafezi; Avinoam B Safran; Joel Salzmann; Arturo Santos; David Birch; Rand Spencer; Artur V Cideciyan; Eugene de Juan; Jacque L Duncan; Dean Eliott; Amani Fawzi; Lisa C Olmos de Koo; Gary C Brown; Julia A Haller; Carl D Regillo; Lucian V Del Priore; Aries Arditi; Duane R Geruschat; Robert J Greenberg Journal: Ophthalmology Date: 2015-07-08 Impact factor: 12.079