Literature DB >> 26156334

Occupational Complexity and Cognitive Reserve in a Middle-Aged Cohort at Risk for Alzheimer's Disease.

Elizabeth A Boots1, Stephanie A Schultz1, Rodrigo P Almeida2, Jennifer M Oh1, Rebecca L Koscik3, Maritza N Dowling4, Catherine L Gallagher5, Cynthia M Carlsson1, Howard A Rowley6, Barbara B Bendlin7, Sanjay Asthana7, Mark A Sager8, Bruce P Hermann8, Sterling C Johnson7, Ozioma C Okonkwo9.   

Abstract

Higher occupational attainment has previously been associated with increased Alzheimer's disease (AD) neuropathology when individuals are matched for cognitive function, indicating occupation could provide cognitive reserve. We examined whether occupational complexity (OCC) associates with decreased hippocampal volume and increased whole-brain atrophy given comparable cognitive function in middle-aged adults at risk for AD. Participants (n = 323) underwent structural MRI, cognitive evaluation, and work history assessment. Three complexity ratings (work with data, people, and things) were obtained, averaged across up to 3 reported jobs, weighted by years per job, and summed to create a composite OCC rating. Greater OCC was associated with decreased hippocampal volume and increased whole-brain atrophy when matched for cognitive function; results remained substantively unchanged after adjusting for several demographic, AD risk, vascular, mental health, and socioeconomic characteristics. These findings suggest that, in people at risk for AD, OCC may confer resilience to the adverse effects of neuropathology on cognition.
© The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  Alzheimer's disease; Cognition; Cognitive reserve; Hippocampus; Imaging; Occupation

Mesh：

Year:  2015        PMID： 26156334      PMCID： PMC4605365          DOI： 10.1093/arclin/acv041

Source DB:  PubMed          Journal:  Arch Clin Neuropsychol        ISSN： 0887-6177            Impact factor:   2.813


  33 in total

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4.  Education and occupation provide reserve in both ApoE ε4 carrier and noncarrier patients with probable Alzheimer's disease.

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7.  Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease.

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8.  Education and occupation as proxies for reserve in aMCI converters and AD: FDG-PET evidence.

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10.  Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake.

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2.  Left frontal cortex connectivity underlies cognitive reserve in prodromal Alzheimer disease.

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3.  Influence of young adult cognitive ability and additional education on later-life cognition.

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Review 4.  Activation of the Brain to Postpone Dementia: A Concept Originating from Postmortem Human Brain Studies.

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5.  Social support and verbal interaction are differentially associated with cognitive function in midlife and older age.

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6.  BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention.

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8.  Association of Neighborhood-Level Disadvantage With Cerebral and Hippocampal Volume.

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Review 9.  The Role of Cognitive Reserve in Alzheimer's Disease and Aging: A Multi-Modal Imaging Review.

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10.  Dissecting the midlife crisis: disentangling social, personality and demographic determinants in social brain anatomy.

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