Literature DB >> 26154417

Human Genome Editing and Ethical Considerations.

Kewal Krishan1, Tanuj Kanchan2, Bahadur Singh3.   

Abstract

Editing human germline genes may act as boon in some genetic and other disorders. Recent editing of the genome of the human embryo with the CRISPR/Cas9 editing tool generated a debate amongst top scientists of the world for the ethical considerations regarding its effect on the future generations. It needs to be seen as to what transformation human gene editing brings to humankind in the times to come.

Entities:  

Keywords:  CRISPR/Cas9 editing tool; Ethical concerns; Human genome

Mesh：

Year:  2015        PMID： 26154417     DOI： 10.1007/s11948-015-9675-8

Source DB:  PubMed          Journal:  Sci Eng Ethics        ISSN： 1353-3452            Impact factor:   3.525


  11 in total

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Authors:  D Micklos; E Carlson
Journal:  Nat Rev Genet       Date:  2000-11       Impact factor: 53.242

2.  Nazi science--the Dachau hypothermia experiments.

Authors:  R L Berger
Journal:  N Engl J Med       Date:  1990-05-17       Impact factor: 91.245

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Authors:  D Butler
Journal:  Nature       Date:  1997-09-04       Impact factor: 49.962

4.  Don't edit the human germ line.

Authors:  Edward Lanphier; Fyodor Urnov; Sarah Ehlen Haecker; Michael Werner; Joanna Smolenski
Journal:  Nature       Date:  2015-03-26       Impact factor: 49.962

5.  Bioethics. Embryo engineering alarm.

Authors:  Gretchen Vogel
Journal:  Science       Date:  2015-03-20       Impact factor: 47.728

6.  The ethics of publishing human germline research.

Authors:  Arun Sharma; Christopher Thomas Scott
Journal:  Nat Biotechnol       Date:  2015-06       Impact factor: 54.908

7.  Construction of biologically functional bacterial plasmids in vitro.

Authors:  S N Cohen; A C Chang; H W Boyer; R B Helling
Journal:  Proc Natl Acad Sci U S A       Date:  1973-11       Impact factor: 11.205

8.  Summary statement of the Asilomar conference on recombinant DNA molecules.

Authors:  P Berg; D Baltimore; S Brenner; R O Roblin; M F Singer
Journal:  Proc Natl Acad Sci U S A       Date:  1975-06       Impact factor: 11.205

9.  Eugenics in Japan: some ironies of modernity, 1883-1945.

Authors:  S Otsubo; J R Bartholomew
Journal:  Sci Context       Date:  1998 Autumn-Winter       Impact factor: 0.425

10.  CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes.

Authors:  Puping Liang; Yanwen Xu; Xiya Zhang; Chenhui Ding; Rui Huang; Zhen Zhang; Jie Lv; Xiaowei Xie; Yuxi Chen; Yujing Li; Ying Sun; Yaofu Bai; Zhou Songyang; Wenbin Ma; Canquan Zhou; Junjiu Huang
Journal:  Protein Cell       Date:  2015-04-18       Impact factor: 14.870
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  8 in total

1.  Enhancement of Pathologist's Routine Practice: Reuse of DNA Extracted from Immunostained Formalin-fixed Paraffin-embedded (FFPE) Slides in Downstream Molecular Analysis of Cancer.

Authors:  Asmaa Al-Attas; Mourad Assidi; Jaudah Al-Maghrabi; Ashraf Dallol; Hans-Juergen Schulten; Muhammad Abu-Elmagd; Adeel Chaudhary; Adel Abuzenadah; Bruce Budowle; Abdelbaset Buhmeida; Mohammed Al-Qahtani
Journal:  Cancer Genomics Proteomics       Date:  2016 09-10       Impact factor: 4.069

2.  Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 Genetic Engineering: Robotic Genetic Surgery.

Authors:  Kaivalya Deshpande; Arpita Vyas; Archana Balakrishnan; Dinesh Vyas
Journal:  Am J Robot Surg       Date:  2015-12

Review 3.  CRISPR-Cas and Its Wide-Ranging Applications: From Human Genome Editing to Environmental Implications, Technical Limitations, Hazards and Bioethical Issues.

Authors:  Roberto Piergentili; Alessandro Del Rio; Fabrizio Signore; Federica Umani Ronchi; Enrico Marinelli; Simona Zaami
Journal:  Cells       Date:  2021-04-21       Impact factor: 7.666

Review 4.  Genome editing: the road of CRISPR/Cas9 from bench to clinic.

Authors:  Ayman Eid; Magdy M Mahfouz
Journal:  Exp Mol Med       Date:  2016-10-14       Impact factor: 8.718

Review 5.  A Broad Overview and Review of CRISPR-Cas Technology and Stem Cells.

Authors:  Simon N Waddington; Riccardo Privolizzi; Rajvinder Karda; Helen C O'Neill
Journal:  Curr Stem Cell Rep       Date:  2016-02-11

Review 6.  Potential Value of Genomic Copy Number Variations in Schizophrenia.

Authors:  Chuanjun Zhuo; Weihong Hou; Chongguang Lin; Lirong Hu; Jie Li
Journal:  Front Mol Neurosci       Date:  2017-06-21       Impact factor: 5.639

Review 7.  Genomic Editing of Non-Coding RNA Genes with CRISPR/Cas9 Ushers in a Potential Novel Approach to Study and Treat Schizophrenia.

Authors:  Chuanjun Zhuo; Weihong Hou; Lirong Hu; Chongguang Lin; Ce Chen; Xiaodong Lin
Journal:  Front Mol Neurosci       Date:  2017-02-03       Impact factor: 5.639

Review 8.  Genome-Editing Technologies: Concept, Pros, and Cons of Various Genome-Editing Techniques and Bioethical Concerns for Clinical Application.

Authors:  Sikandar Hayat Khan
Journal:  Mol Ther Nucleic Acids       Date:  2019-04-03
  8 in total

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