Literature DB >> 26139599

Citizens unite for computational immunology!

Orrin S Belden1, Sarah Catherine Baker1, Brian M Baker2.   

Abstract

Recruiting volunteers who can provide computational time, programming expertise, or puzzle-solving talent has emerged as a powerful tool for biomedical research. Recent projects demonstrate the potential for such 'crowdsourcing' efforts in immunology. Tools for developing applications, new funding opportunities, and an eager public make crowdsourcing a serious option for creative solutions for computationally-challenging problems. Expanded uses of crowdsourcing in immunology will allow for more efficient large-scale data collection and analysis. It will also involve, inspire, educate, and engage the public in a variety of meaningful ways. The benefits are real - it is time to jump in!
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  computational biology; crowdsourcing; distributed computing; immunology

Mesh:

Year:  2015        PMID: 26139599      PMCID: PMC4757455          DOI: 10.1016/j.it.2015.05.004

Source DB:  PubMed          Journal:  Trends Immunol        ISSN: 1471-4906            Impact factor:   16.687


  14 in total

1.  COMPUTING: Screen Savers of the World Unite!

Authors:  M Shirts; V S Pande
Journal:  Science       Date:  2000-12-08       Impact factor: 47.728

Review 2.  Understanding the structural dynamics of TCR-pMHC complex interactions.

Authors:  Itamar Kass; Ashley M Buckle; Natalie A Borg
Journal:  Trends Immunol       Date:  2014-11-11       Impact factor: 16.687

3.  Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing.

Authors:  Mahesh Yadav; Suchit Jhunjhunwala; Qui T Phung; Patrick Lupardus; Joshua Tanguay; Stephanie Bumbaca; Christian Franci; Tommy K Cheung; Jens Fritsche; Toni Weinschenk; Zora Modrusan; Ira Mellman; Jennie R Lill; Lélia Delamarre
Journal:  Nature       Date:  2014-11-27       Impact factor: 49.962

Review 4.  Practically useful: what the Rosetta protein modeling suite can do for you.

Authors:  Kristian W Kaufmann; Gordon H Lemmon; Samuel L Deluca; Jonathan H Sheehan; Jens Meiler
Journal:  Biochemistry       Date:  2010-04-13       Impact factor: 3.162

5.  Predicting protein structures with a multiplayer online game.

Authors:  Seth Cooper; Firas Khatib; Adrien Treuille; Janos Barbero; Jeehyung Lee; Michael Beenen; Andrew Leaver-Fay; David Baker; Zoran Popović; Foldit Players
Journal:  Nature       Date:  2010-08-05       Impact factor: 49.962

6.  Internet-based crowdsourcing and research ethics: the case for IRB review.

Authors:  Mark A Graber; Abraham Graber
Journal:  J Med Ethics       Date:  2012-11-30       Impact factor: 2.903

7.  Prize-based contests can provide solutions to computational biology problems.

Authors:  Karim R Lakhani; Kevin J Boudreau; Po-Ru Loh; Lars Backstrom; Carliss Baldwin; Eric Lonstein; Mike Lydon; Alan MacCormack; Ramy A Arnaout; Eva C Guinan
Journal:  Nat Biotechnol       Date:  2013-02       Impact factor: 54.908

8.  Increased Diels-Alderase activity through backbone remodeling guided by Foldit players.

Authors:  Christopher B Eiben; Justin B Siegel; Jacob B Bale; Seth Cooper; Firas Khatib; Betty W Shen; Foldit Players; Barry L Stoddard; Zoran Popovic; David Baker
Journal:  Nat Biotechnol       Date:  2012-01-22       Impact factor: 54.908

9.  Computational design of an α-gliadin peptidase.

Authors:  Sydney R Gordon; Elizabeth J Stanley; Sarah Wolf; Angus Toland; Sean J Wu; Daniel Hadidi; Jeremy H Mills; David Baker; Ingrid Swanson Pultz; Justin B Siegel
Journal:  J Am Chem Soc       Date:  2012-12-05       Impact factor: 15.419

10.  Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity.

Authors:  Fei Duan; Jorge Duitama; Sahar Al Seesi; Cory M Ayres; Steven A Corcelli; Arpita P Pawashe; Tatiana Blanchard; David McMahon; John Sidney; Alessandro Sette; Brian M Baker; Ion I Mandoiu; Pramod K Srivastava
Journal:  J Exp Med       Date:  2014-09-22       Impact factor: 14.307

View more
  2 in total

Review 1.  Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes.

Authors:  Nishant K Singh; Timothy P Riley; Sarah Catherine B Baker; Tyler Borrman; Zhiping Weng; Brian M Baker
Journal:  J Immunol       Date:  2017-10-01       Impact factor: 5.422

Review 2.  The intersection of affinity and specificity in the development and optimization of T cell receptor based therapeutics.

Authors:  Timothy P Riley; Brian M Baker
Journal:  Semin Cell Dev Biol       Date:  2018-12       Impact factor: 7.499

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.