Characterization of Architectural Distortion in Mammograms Based on Texture Analysis Using Support Vector Machine Classifier with Clinical Evaluation.

Architecture distortion (AD) is an important and early sign of breast cancer, but due to its subtlety, it is often missed on the screening mammograms. The objective of this study is to create a quantitative approach for texture classification of AD based on various texture models, using support vector machine (SVM) classifier. The texture analysis has been done on the region of interest (ROI) selected from the original mammogram. A comprehensive analysis has been done on samples from three databases; out of which, two data sets are from the public domain, and the third data set is for clinical evaluation. The public domain databases are IRMA version of digital database for screening mammogram (DDSM) and Mammographic Image Analysis Society (MIAS). For clinical evaluation, the actual patient's database has been obtained from ACE Healthways, Diagnostic Centre Ludhiana, India. The significant finding of proposed study lies in appropriate selection of the size of ROIs. The experiments have been done on fixed size of ROIs as well as on the ground truth (variable size) ROIs. Best results pertain to an accuracy of 92.94 % obtained in case of DDSM database for fixed-size ROIs. In case of MIAS database, an accuracy of 95.34 % is achieved in AD versus non-AD (normal) cases for ground truth ROIs. Clinically, an accuracy of 88 % was achieved for ACE dataset. The results obtained in the present study are encouraging, as optimal result has been achieved for the proposed study in comparison with other related work in the same area.