Ren Wang1, Jin-Jin Chen2, Bing Hu1. 1. Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine Shanghai 200233, China. 2. Department of Children care and health, Shanghai Children's Hospital Affiliated to Shanghai Jiao Tong University Shanghai 200040, China.
Abstract
OBJECTIVES: The aim of this study is to determine the utility of transrectal real-time elastography (TRTE)-guided prostate biopsies in patients subjected to transrectal ultrasound (TRUS)-guided transperineal prostate biopsies. MATERIALS AND METHODS: A total of 108 consecutive patients suspicious for prostate cancer (PCa) with elevated serum prostate specific antigen (PSA) level > 4 μg/L or abnormal findings on digital rectal examination (DRE) were enrolled in this study. All patients were sequentially underwent 10-cores systematic biopsy and TRTE-guided targeted biopsy. The detection rate of the TRTE-guided targeted biopsy was compared with that of the TRUS-guided 10-cores systematic biopsy, in combination with prostate biopsy pathology. RESULTS: 38 cases among 108 suspicious patients were diagnosed as PCa using the TRUS-guided 10-cores systematic biopsy with a detection rate of 35.2%. Subsequently, a further increase of 13.9% (15/108, P = 0.039) in PCa detection was obtained by the TRTE-guided targeted biopsy. The overall detection rate for PCa was 49.1% (53/108). A total of 1296 cores were sampled among the 108 patients, including 1080 cores for the 10-cores systematic biopsy and 216 cores for the TRTE-guided targeted biopsy cores. The positive rate of the TRTE-guided targeted biopsy was significantly higher than that of the TRUS-guided 10-cores systematic biopsy (50.9% versus 14.1%, P < 0.0001). CONCLUSIONS: TRTE-guided targeted biopsy could be used as a complement to significantly improve the detection rate for PCa in clinical setting.
OBJECTIVES: The aim of this study is to determine the utility of transrectal real-time elastography (TRTE)-guided prostate biopsies in patients subjected to transrectal ultrasound (TRUS)-guided transperineal prostate biopsies. MATERIALS AND METHODS: A total of 108 consecutive patients suspicious for prostate cancer (PCa) with elevated serum prostate specific antigen (PSA) level > 4 μg/L or abnormal findings on digital rectal examination (DRE) were enrolled in this study. All patients were sequentially underwent 10-cores systematic biopsy and TRTE-guided targeted biopsy. The detection rate of the TRTE-guided targeted biopsy was compared with that of the TRUS-guided 10-cores systematic biopsy, in combination with prostate biopsy pathology. RESULTS: 38 cases among 108 suspicious patients were diagnosed as PCa using the TRUS-guided 10-cores systematic biopsy with a detection rate of 35.2%. Subsequently, a further increase of 13.9% (15/108, P = 0.039) in PCa detection was obtained by the TRTE-guided targeted biopsy. The overall detection rate for PCa was 49.1% (53/108). A total of 1296 cores were sampled among the 108 patients, including 1080 cores for the 10-cores systematic biopsy and 216 cores for the TRTE-guided targeted biopsy cores. The positive rate of the TRTE-guided targeted biopsy was significantly higher than that of the TRUS-guided 10-cores systematic biopsy (50.9% versus 14.1%, P < 0.0001). CONCLUSIONS: TRTE-guided targeted biopsy could be used as a complement to significantly improve the detection rate for PCa in clinical setting.
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