Literature DB >> 26131080

Microarray analysis of anti-cancer effects of docosahexaenoic acid on human colon cancer model in nude mice.

Shitao Zou1, Xingjun Meng1, You Meng2, Jin Liu1, Biao Liu3, Shuyu Zhang4, Weiqun Ding5, Jinchang Wu6, Jundong Zhou7.   

Abstract

Docosahexaenoic acid (DHA), a derivative of ω3- polyunsaturated fatty acids present in fish oil, is well known to have anticancer activity on colon cancer cells, but the molecular and cellular mechanisms remain to be further clarified. In this study, anti-cancer effects of DHA on colon cancer cells were observed in a nude mouse HCT-15 xenograft model. And then, the different genes expression and signal pathways involved in this process were screened and identified using cDNA microarray analysis. Results of genes expression profiles indicated a reprogramming pattern of previously known and unknown genes and transcription factors associated with the action of DHA on colon cancer cells. And several genes related to tumor growth and metastasis including COX2, HIF-1α, VEGF-A, COMP, MMP-1, MMP-9, SCP2, SDC3, which were down-regulated by DHA, were further confirmed in HCT-15 cell line using RT-PCR method. In summary, our data might provide novel information for anti-cancer mechanism of DHA in colon cancer model.

Entities:  

Keywords:  DHA; colon cancer; in vivo; microarray analysis; nude mice

Year:  2015        PMID： 26131080      PMCID： PMC4483951     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


  26 in total

1.  Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53.

Authors:  Kaipeng Jing; Kyoung-Sub Song; Soyeon Shin; Nayeong Kim; Soyeon Jeong; Hye-Rim Oh; Ji-Hoon Park; Kang-Sik Seo; Jun-Young Heo; Jeongsu Han; Jong-Il Park; Chang Han; Tong Wu; Gi-Ryang Kweon; Seung-Kiel Park; Wan-Hee Yoon; Byung-Doo Hwang; Kyu Lim
Journal:  Autophagy       Date:  2011-11-01       Impact factor: 16.016

Review 2.  Gene structure, intracellular localization, and functional roles of sterol carrier protein-2.

Authors:  A M Gallegos; B P Atshaves; S M Storey; O Starodub; A D Petrescu; H Huang; A L McIntosh; G G Martin; H Chao; A B Kier; F Schroeder
Journal:  Prog Lipid Res       Date:  2001-11       Impact factor: 16.195

Review 3.  Dietary modification of inflammation with lipids.

Authors:  Philip C Calder
Journal:  Proc Nutr Soc       Date:  2002-08       Impact factor: 6.297

4.  Polyunsaturated fatty acids sensitize human colon adenocarcinoma HT-29 cells to death receptor-mediated apoptosis.

Authors:  Jiøina Hofmanová; Alena Vaculová; Alois Kozubík
Journal:  Cancer Lett       Date:  2005-01-31       Impact factor: 8.679

Review 5.  Assessing identity, phenotype, and fate of endothelial progenitor cells.

Authors:  Karen K Hirschi; David A Ingram; Mervin C Yoder
Journal:  Arterioscler Thromb Vasc Biol       Date:  2008-07-31       Impact factor: 8.311

6.  Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase-2.

Authors:  Kyu Lim; Chang Han; Yifan Dai; Miaoda Shen; Tong Wu
Journal:  Mol Cancer Ther       Date:  2009-11-03       Impact factor: 6.261

7.  Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat.

Authors:  Laurie A Davidson; Danh V Nguyen; Regina M Hokanson; Evelyn S Callaway; Robert B Isett; Nancy D Turner; Edward R Dougherty; Naisyin Wang; Joanne R Lupton; Raymond J Carroll; Robert S Chapkin
Journal:  Cancer Res       Date:  2004-09-15       Impact factor: 12.701

8.  Modulating effect of amount and types of dietary fat on colonic mucosal phospholipase A2, phosphatidylinositol-specific phospholipase C activities, and cyclooxygenase metabolite formation during different stages of colon tumor promotion in male F344 rats.

Authors:  C V Rao; B Simi; T T Wynn; K Garr; B S Reddy
Journal:  Cancer Res       Date:  1996-02-01       Impact factor: 12.701

Review 9.  Genomic and epigenetic instability in colorectal cancer pathogenesis.

Authors:  William M Grady; John M Carethers
Journal:  Gastroenterology       Date:  2008-09-04       Impact factor: 22.682

10.  Cartilage Oligomeric Matrix Protein (COMP): A Biomarker of Arthritis.

Authors:  Susan Tseng; A Hari Reddi; Paul E Di Cesare
Journal:  Biomark Insights       Date:  2009-02-17
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  5 in total

1.  Docosahexaenoic acid and disulfiram act in concert to kill cancer cells: a mutual enhancement of their anticancer actions.

Authors:  Yang Jiao; Bethany N Hannafon; Roy R Zhang; Kar-Ming Fung; Wei-Qun Ding
Journal:  Oncotarget       Date:  2017-03-14

Review 2.  Omega-3 polyunsaturated fatty acids as adjuvant therapy of colorectal cancer.

Authors:  Milene Volpato; Mark A Hull
Journal:  Cancer Metastasis Rev       Date:  2018-09       Impact factor: 9.264

3.  LINC00261 elevation inhibits angiogenesis and cell cycle progression of pancreatic cancer cells by upregulating SCP2 via targeting FOXP3.

Authors:  Jun Zou; Xuanzeng Pei; Dan Xing; Xiaojun Wu; Shuai Chen
Journal:  J Cell Mol Med       Date:  2021-09-19       Impact factor: 5.310

Review 4.  Omega-3 Fatty Acids and Cancer Cell Cytotoxicity: Implications for Multi-Targeted Cancer Therapy.

Authors:  Donatella D'Eliseo; Francesca Velotti
Journal:  J Clin Med       Date:  2016-01-26       Impact factor: 4.241

5.  Establishment of a Patient-Derived Xenograft Model of Colorectal Cancer in CIEA NOG Mice and Exploring Smartfish Liquid Diet as a Source of Omega-3 Fatty Acids.

Authors:  Helle Samdal; Lene C Olsen; Knut S Grøn; Elin S Røyset; Therese S Høiem; Ingunn Nervik; Pål Sætrom; Arne Wibe; Svanhild A Schønberg; Caroline H H Pettersen
Journal:  Biomedicines       Date:  2021-03-10
  5 in total

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