Krystle E Zuniga1, Michael J Mackenzie2, Sarah A Roberts3, Lauren B Raine3, Charles H Hillman3, Arthur F Kramer4, Edward McAuley3. 1. School of Family and Consumer Sciences, Nutrition and Foods Program, Texas State University, 601 University Drive., San Marcos, TX, 78666, USA. k_z17@txstate.edu. 2. Department of Behavioral Health and Nutrition, University of Delaware, Newark, DE, USA. 3. Department of Kinesiology and Community Health, University of Illinois, Urbana, IL, USA. 4. Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, IL, USA.
Abstract
PURPOSE: Nutrition plays an important role in brain structure and function, and the effects of diet may even be greater in those at greater risk of cognitive decline, such as individuals with cancer-related cognitive impairment. However, the relation of dietary components to cognitive function in cancer survivors is unknown. The objective of this study was to determine whether breast cancer survivors (BCS) evidenced impairments in interference control, a component of cognitive control, compared to age-matched women with no prior history of cancer, and to examine the moderating role of diet on cognitive function. METHODS: In this cross-sectional study, a modified flanker task was used to assess interference control in BCS (n = 31) and age-matched women with no prior history of cancer (n = 30). Diet was assessed with 3-day food records. Differences between BCS and age-matched controls were assessed using linear mixed models, and multilevel regression analyses were conducted to assess the moderating role of diet on cognitive performance. RESULTS: Cognitive performance was not different between groups. Fruit intake and vegetable intake were significantly associated with better performance on the incompatible condition of the flanker task (i.e., shorter reaction time and increased accuracy), independent of disease status. The association between dietary components and cognition was stronger for the incompatible incongruent condition, suggesting that fruit and vegetables may be important for the up-regulation of cognitive control when faced with higher cognitive demands. CONCLUSIONS: There was no difference in performance on an interference control task between BCS and age-matched controls. The data suggest that greater fruit intake and vegetable intake were positively associated with interference control in both BCS and age-matched controls.
PURPOSE: Nutrition plays an important role in brain structure and function, and the effects of diet may even be greater in those at greater risk of cognitive decline, such as individuals with cancer-related cognitive impairment. However, the relation of dietary components to cognitive function in cancer survivors is unknown. The objective of this study was to determine whether breast cancer survivors (BCS) evidenced impairments in interference control, a component of cognitive control, compared to age-matched women with no prior history of cancer, and to examine the moderating role of diet on cognitive function. METHODS: In this cross-sectional study, a modified flanker task was used to assess interference control in BCS (n = 31) and age-matched women with no prior history of cancer (n = 30). Diet was assessed with 3-day food records. Differences between BCS and age-matched controls were assessed using linear mixed models, and multilevel regression analyses were conducted to assess the moderating role of diet on cognitive performance. RESULTS: Cognitive performance was not different between groups. Fruit intake and vegetable intake were significantly associated with better performance on the incompatible condition of the flanker task (i.e., shorter reaction time and increased accuracy), independent of disease status. The association between dietary components and cognition was stronger for the incompatible incongruent condition, suggesting that fruit and vegetables may be important for the up-regulation of cognitive control when faced with higher cognitive demands. CONCLUSIONS: There was no difference in performance on an interference control task between BCS and age-matched controls. The data suggest that greater fruit intake and vegetable intake were positively associated with interference control in both BCS and age-matched controls.
Entities:
Keywords:
Cancer survivors; Cognition; Fruit; Vegetable
Authors: G L Bowman; L C Silbert; D Howieson; H H Dodge; M G Traber; B Frei; J A Kaye; J Shannon; J F Quinn Journal: Neurology Date: 2011-12-28 Impact factor: 9.910
Authors: Christina L Sherry; Stephanie S Kim; Ryan N Dilger; Laura L Bauer; Morgan L Moon; Richard I Tapping; George C Fahey; Kelly A Tappenden; Gregory G Freund Journal: Brain Behav Immun Date: 2010-02-06 Impact factor: 7.217
Authors: Heather S L Jim; Kristin M Phillips; Sari Chait; Leigh Anne Faul; Mihaela A Popa; Yun-Hsiang Lee; Mallory G Hussin; Paul B Jacobsen; Brent J Small Journal: J Clin Oncol Date: 2012-08-27 Impact factor: 44.544
Authors: Anne M Walk; Naiman A Khan; Sasha M Barnett; Lauren B Raine; Arthur F Kramer; Neal J Cohen; Christopher J Moulton; Lisa M Renzi-Hammond; Billy R Hammond; Charles H Hillman Journal: Int J Psychophysiol Date: 2017-05-19 Impact factor: 2.997
Authors: Steve Amireault; Jennifer Brunet; Jordan D Kurth; Angela J Fong; Catherine M Sabiston Journal: Curr Oncol Date: 2021-11-30 Impact factor: 3.677