K-A Git1, L A B Fioravante2, J L Fernandes2. 1. 1 Department of Radiology, Hospital Selayang, Selangor, Malaysia. 2. 2 Jose Michel Kalaf Research Institute, Campinas, Brazil.
Abstract
OBJECTIVE: To assess whether an online open-source tool would provide accurate calculations of T2(*) values for iron concentrations in the liver and heart compared with a standard reference software. METHODS: An online open-source tool, written in pure HTML5/Javascript, was tested in 50 patients (age 26.0 ± 18.9 years, 46% males) who underwent T2(*) MRI of the liver and heart for iron overload assessment as part of their routine workup. Automated truncation correction was the default with optional manual adjustment provided if needed. The results were compared against a standard reference measurement using commercial software with manual truncation (CVI(42)(®) v. 5.1; Circle Cardiovascular Imaging; Calgary, AB). RESULTS: The mean liver T2(*) values calculated with the automated tool was 4.3 ms [95% confidence interval (CI) 3.1 to 5.5 ms] vs 4.26 ms using the reference software (95% CI 3.1 to 5.4 ms) without any significant differences (p = 0.71). In the liver, the mean difference was 0.036 ms (95% CI -0.1609 to 0.2329 ms) with a regression correlation coefficient of 0.97. For the heart, the automated T2(*) value was 26.0 ms (95% CI 22.9 to 29.0 ms) vs 25.3 ms (95% CI 22.3 to 28.3 ms), p = 0.28. The mean difference was 0.72 ms (95% CI 0.08191 to 1.3621 ms) with a correlation coefficient of 0.96. CONCLUSION: The automated online tool provides similar T2(*) values for the liver and myocardial iron concentrations as compared with a standard reference software. ADVANCES IN KNOWLEDGE: The online program provides an open-source tool for the calculation of T2(*) values, incorporating an automated correction algorithm in a simple and easy-to-use interface.
OBJECTIVE: To assess whether an online open-source tool would provide accurate calculations of T2(*) values for iron concentrations in the liver and heart compared with a standard reference software. METHODS: An online open-source tool, written in pure HTML5/Javascript, was tested in 50 patients (age 26.0 ± 18.9 years, 46% males) who underwent T2(*) MRI of the liver and heart for iron overload assessment as part of their routine workup. Automated truncation correction was the default with optional manual adjustment provided if needed. The results were compared against a standard reference measurement using commercial software with manual truncation (CVI(42)(®) v. 5.1; Circle Cardiovascular Imaging; Calgary, AB). RESULTS: The mean liver T2(*) values calculated with the automated tool was 4.3 ms [95% confidence interval (CI) 3.1 to 5.5 ms] vs 4.26 ms using the reference software (95% CI 3.1 to 5.4 ms) without any significant differences (p = 0.71). In the liver, the mean difference was 0.036 ms (95% CI -0.1609 to 0.2329 ms) with a regression correlation coefficient of 0.97. For the heart, the automated T2(*) value was 26.0 ms (95% CI 22.9 to 29.0 ms) vs 25.3 ms (95% CI 22.3 to 28.3 ms), p = 0.28. The mean difference was 0.72 ms (95% CI 0.08191 to 1.3621 ms) with a correlation coefficient of 0.96. CONCLUSION: The automated online tool provides similar T2(*) values for the liver and myocardial iron concentrations as compared with a standard reference software. ADVANCES IN KNOWLEDGE: The online program provides an open-source tool for the calculation of T2(*) values, incorporating an automated correction algorithm in a simple and easy-to-use interface.
Authors: Nilesh R Ghugre; Cathleen M Enriquez; Thomas D Coates; Marvin D Nelson; John C Wood Journal: J Magn Reson Imaging Date: 2006-01 Impact factor: 4.813
Authors: Taigang He; Peter D Gatehouse; Paul Kirk; Mark A Tanner; Gillian C Smith; Jennifer Keegan; Raad H Mohiaddin; Dudley J Pennell; David N Firmin Journal: J Magn Reson Imaging Date: 2007-06 Impact factor: 4.813
Authors: Juliano L Fernandes; Erika Fontana Sampaio; Monica Verissimo; Fabricio B Pereira; Jose Alvaro da Silva; Gabriel S de Figueiredo; Jose M Kalaf; Otavio R Coelho Journal: Eur Radiol Date: 2011-08-13 Impact factor: 5.315
Authors: John-Paul Carpenter; Taigang He; Paul Kirk; Michael Roughton; Lisa J Anderson; Sofia V de Noronha; Mary N Sheppard; John B Porter; J Malcolm Walker; John C Wood; Renzo Galanello; Gianluca Forni; Gualtiero Catani; Gildo Matta; Suthat Fucharoen; Adam Fleming; Michael J House; Greg Black; David N Firmin; Timothy G St Pierre; Dudley J Pennell Journal: Circulation Date: 2011-03-28 Impact factor: 29.690
Authors: Taigang He; Peter D Gatehouse; Gillian C Smith; Raad H Mohiaddin; Dudley J Pennell; David N Firmin Journal: Magn Reson Med Date: 2008-11 Impact factor: 4.668
Authors: Jane S Hankins; M Beth McCarville; Ralf B Loeffler; Matthew P Smeltzer; Mihaela Onciu; Fredric A Hoffer; Chin-Shang Li; Winfred C Wang; Russell E Ware; Claudia M Hillenbrand Journal: Blood Date: 2009-03-04 Impact factor: 22.113
Authors: G J H Snel; M van den Boomen; L M Hernandez; C T Nguyen; D E Sosnovik; B K Velthuis; R H J A Slart; R J H Borra; N H J Prakken Journal: J Cardiovasc Magn Reson Date: 2020-05-11 Impact factor: 5.364