Anja Tschugg1, Wolfgang N Löscher2, Sebastian Hartmann1, Sabrina Neururer3, Matthias Wildauer4, Claudius Thomé1. 1. 1 Department of Neurosurgery, Medical University Innsbruck , Innsbruck, Austria . 2. 2 Department of Neurology, Medical University Innsbruck , Innsbruck, Austria . 3. 3 Department of Medical Statistics and Health Economics, Medical University Innsbruck , Innsbruck, Austria . 4. 4 Department of Neuroradiology, Medical University Innsbruck , Innsbruck, Austria .
Abstract
BACKGROUND: Previous studies have demonstrated gender differences in pain perception in quantitative sensory testing. Thus, we hypothesized that there are differences in men and women with lumbar disc herniation awaiting lumbar sequestrectomy. To elucidate the differences in pain perception between men and women, we carried out a prospective clinical monocentric trial using quantitative sensory testing. METHODS: With institutional ethical approval, patients with radiculopathy awaiting lumbar sequestrectomy were examined the day before surgery. Preoperative pain was assessed using quantitative sensory testing and a series of questionnaires including Beck Depression Inventory and a numeric rating scale (NRS) for back and leg pain. Statistical analysis was performed using the Kolmogorov-Smirnov test for normal distribution. The unpaired Student's t-test, Mann-Whitney U test, and Fisher's exact test were used to analyze intergroup differences in the clinical and demographic characteristics and in clinical outcome variables. RESULTS: Fifty patients (20 women and 30 men) were included in the study. The groups did not differ in NRS for back and leg pain. Heat and pressure pain thresholds were found to be lower in women than in men (p≤0.05). Subgroup analyses revealed decreased wind-up ratio in male patients with prior periradicular steroid application (p≤0.05). CONCLUSIONS: Our results clearly indicate that sex differences in pain perception not only exist in healthy subjects, but also in patients with lumbar disc herniation. Therefore, it is essential to provide different treatment modalities to women and men.
BACKGROUND: Previous studies have demonstrated gender differences in pain perception in quantitative sensory testing. Thus, we hypothesized that there are differences in men and women with lumbar disc herniation awaiting lumbar sequestrectomy. To elucidate the differences in pain perception between men and women, we carried out a prospective clinical monocentric trial using quantitative sensory testing. METHODS: With institutional ethical approval, patients with radiculopathy awaiting lumbar sequestrectomy were examined the day before surgery. Preoperative pain was assessed using quantitative sensory testing and a series of questionnaires including Beck Depression Inventory and a numeric rating scale (NRS) for back and leg pain. Statistical analysis was performed using the Kolmogorov-Smirnov test for normal distribution. The unpaired Student's t-test, Mann-Whitney U test, and Fisher's exact test were used to analyze intergroup differences in the clinical and demographic characteristics and in clinical outcome variables. RESULTS: Fifty patients (20 women and 30 men) were included in the study. The groups did not differ in NRS for back and leg pain. Heat and pressure pain thresholds were found to be lower in women than in men (p≤0.05). Subgroup analyses revealed decreased wind-up ratio in male patients with prior periradicular steroid application (p≤0.05). CONCLUSIONS: Our results clearly indicate that sex differences in pain perception not only exist in healthy subjects, but also in patients with lumbar disc herniation. Therefore, it is essential to provide different treatment modalities to women and men.
Authors: Anja Tschugg; Sara Lener; Sebastian Hartmann; Sabrina Neururer; Matthias Wildauer; Claudius Thomé; Wolfgang N Löscher Journal: Eur Spine J Date: 2016-09-16 Impact factor: 3.134
Authors: Anja Tschugg; Wolfgang N Löscher; Sara Lener; Matthias Wildauer; Sebastian Hartmann; Sabrina Neururer; Claudius Thomé Journal: Eur Spine J Date: 2016-12-21 Impact factor: 3.134
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Authors: Sara Lener; Christoph Wipplinger; Sebastian Hartmann; Wolfgang N Löscher; Sabrina Neururer; Matthias Wildauer; Claudius Thomé; Anja Tschugg Journal: Trials Date: 2017-11-25 Impact factor: 2.279