| Literature DB >> 26100230 |
Rubia van den Brand1, Jean-Baptiste Mignardot2, Joachim von Zitzewitz2, Camille Le Goff2, Nicolas Fumeaux2, Fabien Wagner2, Marco Capogrosso3, Eduardo Martin Moraud3, Silvestro Micera3, Brigitte Schurch4, Armin Curt5, Stefano Carda4, Jocelyne Bloch4, Grégoire Courtine2.
Abstract
Spinal cord injury leads to a range of disabilities, including limitations in locomotor activity, that seriously diminish the patients' autonomy and quality of life. Electrochemical neuromodulation therapies, robot-assisted rehabilitation and willpower-based training paradigms restored supraspinal control of locomotion in rodent models of severe spinal cord injury. This treatment promoted extensive and ubiquitous remodeling of spared circuits and residual neural pathways. In four chronic paraplegic individuals, electrical neuromodulation of the spinal cord resulted in the immediate recovery of voluntary leg movements, suggesting that the therapeutic concepts developed in rodent models may also apply to humans. Here, we briefly review previous work, summarize current developments, and highlight impediments to translate these interventions into medical practice to improve functional recovery of spinal-cord-injured individuals.Entities:
Keywords: Electrical neuromodulation; Electrochemical neuromodulation; Neuroprosthetic technologies; Neurorehabilitation; Spinal cord injury; Translational research
Mesh：
Year: 2015 PMID： 26100230 DOI： 10.1016/j.rehab.2015.04.003
Source DB: PubMed Journal: Ann Phys Rehabil Med ISSN： 1877-0657