Morten Agger1, Flemming Scheutz2, Steen Villumsen2, Kåre Mølbak3, Andreas Munk Petersen4. 1. Department of Internal Medicine, Trelleborg Hospital, Trelleborg, Sweden. 2. WHO Collaborating Centre for Reference and Research on Escherichia and Klebsiella, Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark. 3. Department of Infectious Disease Epidemiology, Statens Serum Institut, Copenhagen, Denmark. 4. Department of Gastroenterology, Hvidovre University Hospital, 2650 Hvidovre, Denmark Department of Clinical Microbiology, Hvidovre University Hospital, 2650 Hvidovre, Denmark andreas.munk.petersen@regionh.dk.
Abstract
OBJECTIVES: A consensus has existed on not to treat verocytotoxin-producing Escherichia coli (VTEC)-infected individuals with antibiotics because of possible subsequent increased risk of developing haemolytic uraemic syndrome (HUS). The aim of this systematic review is to clarify the risk associated with antibiotic treatment during acute VTEC infection and in chronic VTEC carrier states. METHODS: A systematic search in PubMed identified 1 meta-analysis, 10 clinical studies and 22 in vitro/in vivo studies. RESULTS: Four clinical studies found an increased risk of HUS, four studies found no altered risk of HUS and two studies found a protective effect of antibiotics. In vitro and clinical studies suggest that DNA synthesis inhibitors should be avoided, whereas evidence from in vitro studies indicates that certain protein and cell wall synthesis inhibitors reduce the release of toxins from VTEC isolates. Overall, these studies provide a more nuanced view of the diversity of responses by VTEC strains to antibiotics. CONCLUSIONS: Based on these data, as well as data from the Danish cohort of registered VTEC infections, we propose that antibiotic treatment with protein and cell wall synthesis inhibitors can be considered when specific criteria regarding patient group, serotype, virulence profile and duration of disease are met.
OBJECTIVES: A consensus has existed on not to treat verocytotoxin-producing Escherichia coli (VTEC)-infected individuals with antibiotics because of possible subsequent increased risk of developing haemolytic uraemic syndrome (HUS). The aim of this systematic review is to clarify the risk associated with antibiotic treatment during acute VTEC infection and in chronic VTEC carrier states. METHODS: A systematic search in PubMed identified 1 meta-analysis, 10 clinical studies and 22 in vitro/in vivo studies. RESULTS: Four clinical studies found an increased risk of HUS, four studies found no altered risk of HUS and two studies found a protective effect of antibiotics. In vitro and clinical studies suggest that DNA synthesis inhibitors should be avoided, whereas evidence from in vitro studies indicates that certain protein and cell wall synthesis inhibitors reduce the release of toxins from VTEC isolates. Overall, these studies provide a more nuanced view of the diversity of responses by VTEC strains to antibiotics. CONCLUSIONS: Based on these data, as well as data from the Danish cohort of registered VTEC infections, we propose that antibiotic treatment with protein and cell wall synthesis inhibitors can be considered when specific criteria regarding patient group, serotype, virulence profile and duration of disease are met.
Authors: Kioa L Wijnsma; Anne M Schijvens; John W A Rossen; A M D Mirjam Kooistra-Smid; Michiel F Schreuder; Nicole C A J van de Kar Journal: Pediatr Nephrol Date: 2017-03-25 Impact factor: 3.714
Authors: Oluwaseun B Esan; Madison Pearce; Oliver van Hecke; Nia Roberts; Dylan R J Collins; Mara Violato; Noel McCarthy; Rafael Perera; Thomas R Fanshawe Journal: EBioMedicine Date: 2016-12-08 Impact factor: 8.143