Influence of unbound fraction and perfusate flow rate on taurocholate elimination by perfused rat liver: applicability of three distributed models.

The applicability of three different distributed models to the kinetics of elimination of taurocholate by isolated perfused rat liver was examined by fitting each model to literature data. Each of the models was able to predict the effect of changing hepatic blood flow on elimination, but only the model which incorporates separate density functions describing the degree of sinusoidal heterogeneity of blood flow and intrinsic clearance was able to predict the effect of changing unbound fraction on elimination.