Literature DB >> 4006023

Hepatic drug clearance model: comparison among the distributed, parallel-tube and well-stirred models.

Y Sawada, Y Sugiyama, Y Miyamoto, T Iga, M Hanano.   

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Year:  1985        PMID： 4006023     DOI： 10.1248/cpb.33.319

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


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  12 in total

1.  Availability predictions by hepatic elimination models for Michaelis-Menten kinetics.

Authors:  M S Roberts; J D Donaldson; D Jackett
Journal:  J Pharmacokinet Biopharm       Date:  1989-12

2.  A comparative investigation of hepatic clearance models: predictions of metabolite formation and elimination.

Authors:  M V St-Pierre; P I Lee; K S Pang
Journal:  J Pharmacokinet Biopharm       Date:  1992-04

3.  Axial tissue diffusion can account for the disparity between current models of hepatic elimination for lipophilic drugs.

Authors:  L P Rivory; M S Roberts; S M Pond
Journal:  J Pharmacokinet Biopharm       Date:  1992-02

Review 4.  Modeling kinetics of subcellular disposition of chemicals.

Authors:  Stefan Balaz
Journal:  Chem Rev       Date:  2009-05       Impact factor: 60.622

Review 5.  Clinical significance of pharmacokinetic models of hepatic elimination.

Authors:  D J Morgan; R A Smallwood
Journal:  Clin Pharmacokinet       Date:  1990-01       Impact factor: 6.447

6.  Influence of unbound fraction and perfusate flow rate on taurocholate elimination by perfused rat liver: applicability of three distributed models.

Authors:  D J Morgan
Journal:  Pharm Res       Date:  1989-10       Impact factor: 4.200

7.  Effects of perfusate flow rate on measured blood volume, disse space, intracellular water space, and drug extraction in the perfused rat liver preparation: characterization by the multiple indicator dilution technique.

Authors:  K S Pang; W F Lee; W F Cherry; V Yuen; J Accaputo; S Fayz; A J Schwab; C A Goresky
Journal:  J Pharmacokinet Biopharm       Date:  1988-12

8.  A dispersion model of hepatic elimination: 2. Steady-state considerations--influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity.

Authors:  M S Roberts; M Rowland
Journal:  J Pharmacokinet Biopharm       Date:  1986-06

9.  Models of hepatic elimination: comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity, and systemic recycling on hepatic elimination.

Authors:  M S Roberts; J D Donaldson; M Rowland
Journal:  J Pharmacokinet Biopharm       Date:  1988-02

10.  An enzyme-distributed system for lidocaine metabolism in the perfused rat liver preparation.

Authors:  K S Pang; J A Terrell; S D Nelson; K F Feuer; M J Clements; L Endrenyi
Journal:  J Pharmacokinet Biopharm       Date:  1986-04
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