Literature DB >> 6258226

Receptor for albumin on the liver cell surface may mediate uptake of fatty acids and other albumin-bound substances.

R Weisiger, J Gollan, R Ockner.   

Abstract

Kinetic analysis of the uptake of carbon-14-labeled oleate in a single-pass perfusion of rat liver and saturable and specific binding of iodine-125-labeled albumin to hepatocytes in suspension suggest the existence of a receptor for albumin on the liver cell surface. The putative receptor appears to mediate uptake of albumin-bound fatty acids by the cell and may account for the efficient hepatic extraction of many other substances tightly bound to albumin.

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Year:  1981        PMID： 6258226     DOI： 10.1126/science.6258226

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  76 in total

1.  Facilitated diffusion and membrane permeation of fatty acid in albumin solutions.

Authors:  E Barta; S Sideman; J B Bassingthwaighte
Journal:  Ann Biomed Eng       Date:  2000-03       Impact factor: 3.934

2.  Kinetic analysis of the dose-dependent hepatic handling of 1-anilino-8-naphthalene sulfonate in rats.

Authors:  Y B Chung; S Miyauchi; Y Sugiyama; H Harashima; T Iga; M Hanano
Journal:  J Pharmacokinet Biopharm       Date:  1990-08

3.  Lightning and the Heart: Fractal Behavior in Cardiac Function.

Authors:  James B Bassingthwaighte; J H G M van Beek
Journal:  Proc IEEE Inst Electr Electron Eng       Date:  2002-08-06       Impact factor: 10.961

4.  Residence time distributions of solutes in the perfused rat liver using a dispersion model of hepatic elimination: 1. Effect of changes in perfusate flow and albumin concentration on sucrose and taurocholate.

Authors:  M S Roberts; S Fraser; A Wagner; L McLeod
Journal:  J Pharmacokinet Biopharm       Date:  1990-06

Review 5.  Covalent and noncovalent protein binding of drugs: implications for hepatic clearance, storage, and cell-specific drug delivery.

Authors:  D K Meijer; P van der Sluijs
Journal:  Pharm Res       Date:  1989-02       Impact factor: 4.200

6.  Testing and characterizing enzymes and membrane-bound carrier proteins acting on amphipathic ligands in the presence of bilayer membrane material and soluble binding protein. Application to the uptake of oleate into isolated cells.

Authors:  K P Heirwegh; J A Meuwissen
Journal:  Biochem J       Date:  1992-06-01       Impact factor: 3.857

7.  Effects of free fatty acids on the binding of steroid hormones to bovine serum albumin.

Authors:  S Watanabe; T Tani; S Watanabe; M Seno
Journal:  Lipids       Date:  1990-10       Impact factor: 1.880

8.  Quantitation of plasma membrane fatty acid-binding protein by enzyme dilution and monoclonal antibody based immunoassay.

Authors:  S L Zhou; B J Potter; D Stump; D Sorrentino; P D Berk
Journal:  Mol Cell Biochem       Date:  1990 Oct 15-Nov 8       Impact factor: 3.396

Review 9.  Transmembrane transport of fatty acids in the heart.

Authors:  W Stremmel
Journal:  Mol Cell Biochem       Date:  1989 Jun 27-Jul 24       Impact factor: 3.396

10.  A direct role for serum albumin in the cellular uptake of long-chain fatty acids.

Authors:  B L Trigatti; G E Gerber
Journal:  Biochem J       Date:  1995-05-15       Impact factor: 3.857
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