Jing Yuan1, Zhenxin Zhang2, Hongbo Wen1, Xia Hong1, Zhen Hong3, Qiumin Qu4, Mouni Tang5, Jixing Wu6, Qun Xu7, Hui Li7, Jeffrey L Cummings8. 1. Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China. 2. Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; Department of Clinical Epidemiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China. Electronic address: wuzhangzhenxin@163.com. 3. Department of Neurology, Huashan Hospital, Fudan University, Shanghai, People's Republic of China. 4. Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China. 5. Department of Psychiatry, The First Hospital, Huaxi Medical College, Chengdu, People's Republic of China. 6. Department of Neurology, Beijing Sixth Hospital, Beijing, People's Republic of China. 7. Department of Epidemiology and Biostatistics, Institute of Basic Medicine Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, People's Republic of China. 8. Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.
Abstract
INTRODUCTION: There is a dearth of literature on the incidence of dementia in China. METHODS: Using a stratified, multistage, cluster-sampling method, 16,921 nondemented participants ≥55 years were recruited from four regional centers in China in 1997 and followed up to 4.5 years. Cases were identified through a three-step protocol, according to standardized criteria for dementia, Alzheimer's dementia (AD), and vascular dementia (VaD). RESULTS: The crude incidence in persons ≥65 years was 12.1/1000 person-years for dementia, 8.2/1000 person-years for AD, and 3.1/1000 person-years for VaD. After adjusting for sociodemographic factors, older age and lower education were associated with a higher risk of incident dementia, AD and VaD; regional difference was associated mainly with incidence of VaD (north vs. south: hazard ratio [HR] = 3.59); modestly with AD (east vs. west: HR = 1.55). DISCUSSION: The incidence of dementia in Chinese population is comparable with that in Europe and United States.
INTRODUCTION: There is a dearth of literature on the incidence of dementia in China. METHODS: Using a stratified, multistage, cluster-sampling method, 16,921 nondemented participants ≥55 years were recruited from four regional centers in China in 1997 and followed up to 4.5 years. Cases were identified through a three-step protocol, according to standardized criteria for dementia, Alzheimer's dementia (AD), and vascular dementia (VaD). RESULTS: The crude incidence in persons ≥65 years was 12.1/1000 person-years for dementia, 8.2/1000 person-years for AD, and 3.1/1000 person-years for VaD. After adjusting for sociodemographic factors, older age and lower education were associated with a higher risk of incident dementia, AD and VaD; regional difference was associated mainly with incidence of VaD (north vs. south: hazard ratio [HR] = 3.59); modestly with AD (east vs. west: HR = 1.55). DISCUSSION: The incidence of dementia in Chinese population is comparable with that in Europe and United States.
Authors: Qing Ke; Li Zhang; Chaying He; Zhengyan Zhao; Ming Qi; Robert C Griggs; Michele A Gatheridge Journal: Neurology Date: 2016-08-23 Impact factor: 9.910