Qinqin Meng1, Huali Wang2, John Strauss3, Kenneth M Langa4, Xinxin Chen1, Mingwei Wang5, Qiumin Qu6, Wei Chen7, Weihong Kuang8, Nan Zhang9, Tao Li2, Yafeng Wang1, Yaohui Zhao10. 1. Institute of Social Science Survey, Peking University, Beijing, China. 2. Dementia Care & Research Center, Beijing Dementia Key Lab, Peking University Institute of Mental Health (Sixth Hospital), National Clinical Research Center for Mental Health, Key Laboratory of Mental Health, National Health Commission, Beijing, China. 3. Department of Economics, University of Southern California, Los Angeles, CA, USA. 4. Medical School, Institute for Social Research, Institute for Healthcare Policy and Innovation, Veterans Affairs Center for Clinical Management Research, University of Michigan, Ann Arbor, MI, USA. 5. The First Hospital of Hebei Medical University, Brain Aging and Cognitive Neuroscience Key Laboratory of Hebei Province, Hebei, Shijiazhuang, China. 6. First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. 7. Sir Shaw Run Hospital, School of Medicine, Zhejiang University, Zhejiang, China. 8. West China Hospital, Sichuan University, Chengdu, China. 9. Tianjin Medical University General Hospital, Tianjin, China. 10. National School of Development, Peking University, Beijing, China.
Abstract
OBJECTIVE: To compare and validate neurocognitive tests in the Harmonized Cognitive Assessment Protocol (HCAP) for the China Health and Retirement Longitudinal Study (CHARLS), and to identify appropriate tests to be administered in future waves of CHARLS. METHODS: We recruited 825 individuals from the CHARLS sample and 766 subjects from hospitals in six provinces and cities in China. All participants were administered the HCAP-neurocognitive tests, and their informants were interviewed regarding the respondents' functional status. Trained clinicians administered the Clinical Dementia Rating scale (CDR) to assess the respondents' cognitive status independently. RESULTS: The testing protocol took an average of 58 minutes to complete. Refusal rates for tests of general cognition, episodic memory, and language were less than 10%. All neurocognitive test scores significantly correlated with the CDR global score (correlation coefficients ranged from 0.139 to 0.641). The Mini-Mental State Examination (MMSE), the Health and Retirement Study (HRS) - telephone interview for cognitive status (TICS), community screening instrument for dementia (CSI-D) for respondent, episodic memory and language tests each accounted for more than 20% of the variance in global CDR score (p < 0.001) in bivariate tests. In the CHARLS subsample, age and education were associated with neuropsychological performance across most cognitive domains, and with functional status. CONCLUSION: A brief set of the CHARLS-HCAP neurocognitive tests are feasible and valid to be used in the CHARLS sample and hospital samples. It could be applied in the future waves of the CHARLS study, and it allows estimating the prevalence of dementia in China through the population-based CHARLS.
OBJECTIVE: To compare and validate neurocognitive tests in the Harmonized Cognitive Assessment Protocol (HCAP) for the China Health and Retirement Longitudinal Study (CHARLS), and to identify appropriate tests to be administered in future waves of CHARLS. METHODS: We recruited 825 individuals from the CHARLS sample and 766 subjects from hospitals in six provinces and cities in China. All participants were administered the HCAP-neurocognitive tests, and their informants were interviewed regarding the respondents' functional status. Trained clinicians administered the Clinical Dementia Rating scale (CDR) to assess the respondents' cognitive status independently. RESULTS: The testing protocol took an average of 58 minutes to complete. Refusal rates for tests of general cognition, episodic memory, and language were less than 10%. All neurocognitive test scores significantly correlated with the CDR global score (correlation coefficients ranged from 0.139 to 0.641). The Mini-Mental State Examination (MMSE), the Health and Retirement Study (HRS) - telephone interview for cognitive status (TICS), community screening instrument for dementia (CSI-D) for respondent, episodic memory and language tests each accounted for more than 20% of the variance in global CDR score (p < 0.001) in bivariate tests. In the CHARLS subsample, age and education were associated with neuropsychological performance across most cognitive domains, and with functional status. CONCLUSION: A brief set of the CHARLS-HCAP neurocognitive tests are feasible and valid to be used in the CHARLS sample and hospital samples. It could be applied in the future waves of the CHARLS study, and it allows estimating the prevalence of dementia in China through the population-based CHARLS.
Entities:
Keywords:
cognitive testing; dementia; elderly; memory; population
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