Literature DB >> 26077434

Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders.

Christina N Vallianatos1,2, Shigeki Iwase1.   

Abstract

Methylation of histone H3 lysine 4 (H3K4me) is an intricately regulated posttranslational modification, which is broadly associated with enhancers and promoters of actively transcribed genomic loci. Recent advances in next-generation sequencing have identified a number of H3K4me regulators mutated in neurodevelopmental disorders including intellectual disabilities, autism spectrum disorders, and schizophrenia. Here, we aim to summarize the molecular function of H3K4me-regulating enzymes in brain development and function. We describe four H3K4me methyltransferases (KMT2A, KMT2C, KMT2D, KMT2F), four demethylases (KDM1A, KDM5A, KDM5B, KDM5C), and two reader proteins (PHF21A, PHF8) mutated in neurodevelopmental disorders. Understanding the role of these chromatin regulators in the development and maintenance of neural connections will advance therapeutic opportunities for prevention and treatment of these lifelong neurodevelopmental disorders.

Entities:  

Keywords:  H3K4 methylation; autism spectrum disorders; brain development; chromatin; epigenetics; gene regulation; histone methylation; intellectual disability; schizophrenia

Mesh：

Substances：

Year:  2015        PMID： 26077434      PMCID： PMC4501478          DOI： 10.2217/epi.15.1

Source DB:  PubMed          Journal:  Epigenomics        ISSN： 1750-192X            Impact factor:   4.778


  142 in total

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Review 3.  Chromatin proteins and modifications as drug targets.

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Journal:  Nature       Date:  2013-10-24       Impact factor: 49.962

4.  Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome.

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Journal:  Nat Genet       Date:  2007-02-04       Impact factor: 38.330

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6.  A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation.

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Journal:  Mol Cell       Date:  2010-03-25       Impact factor: 17.970

7.  Functional analysis of the transcription repressor PLU-1/JARID1B.

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Review 8.  Handpicking epigenetic marks with PHD fingers.

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9.  De Novo variants in the KMT2A (MLL) gene causing atypical Wiedemann-Steiner syndrome in two unrelated individuals identified by clinical exome sequencing.

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10.  Cfp1 is required for gene expression-dependent H3K4 trimethylation and H3K9 acetylation in embryonic stem cells.

Authors:  Thomas Clouaire; Shaun Webb; Adrian Bird
Journal:  Genome Biol       Date:  2014-09-04       Impact factor: 13.583
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  66 in total

Review 1.  Touch, act and go: landing and operating on nucleosomes.

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Journal:  EMBO J       Date:  2016-01-19       Impact factor: 11.598

Review 2.  Yin-yang actions of histone methylation regulatory complexes in the brain.

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Journal:  Epigenomics       Date:  2016-11-18       Impact factor: 4.778

3.  Sulforaphane protects against ethanol-induced apoptosis in neural crest cells through restoring epithelial-mesenchymal transition by epigenetically modulating the expression of Snail1.

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Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2019-07-08       Impact factor: 5.187

4.  Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.

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Journal:  Hum Mol Genet       Date:  2019-12-15       Impact factor: 6.150

Review 5.  Toward development of epigenetic drugs for central nervous system disorders: Modulating neuroplasticity via H3K4 methylation.

Authors:  Emily L Ricq; Jacob M Hooker; Stephen J Haggarty
Journal:  Psychiatry Clin Neurosci       Date:  2016-09-07       Impact factor: 5.188

6.  A Drosophila Model of Intellectual Disability Caused by Mutations in the Histone Demethylase KDM5.

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Review 7.  Epigenetic Etiology of Intellectual Disability.

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8.  Transcriptional Changes following Cellular Knockdown of the Schizophrenia Risk Gene SETD1A Are Enriched for Common Variant Association with the Disorder.

Authors:  Darren Cameron; Derek J Blake; Nicholas J Bray; Matthew J Hill
Journal:  Mol Neuropsychiatry       Date:  2019-03-25

Review 9.  The epigenomics of schizophrenia, in the mouse.

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Review 10.  KDM5B is a master regulator of the H3K4-methylome in stem cells, development and cancer.

Authors:  Besa Xhabija; Benjamin L Kidder
Journal:  Semin Cancer Biol       Date:  2018-11-16       Impact factor: 15.707
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