Literature DB >> 30448242

KDM5B is a master regulator of the H3K4-methylome in stem cells, development and cancer.

Besa Xhabija1, Benjamin L Kidder2.   

Abstract

Epigenetic regulation of chromatin plays a critical role in controlling stem cell function and tumorigenesis. The histone lysine demethylase, KDM5B, which catalyzes the demethylation of histone 3 lysine 4 (H3K4), is important for embryonic stem (ES) cell differentiation, and is a critical regulator of the H3K4-methylome during early mouse embryonic pre-implantation stage development. KDM5B is also overexpressed, amplified, or mutated in many cancer types. In cancer cells, KDM5B regulates expression of oncogenes and tumor suppressors by modulating H3K4 methylation levels. In this review, we examine how KDM5B regulates gene expression and cellular fates of stem cells and cancer cells by temporally and spatially controlling H3K4 methylation levels.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Cancer; Chromatin; Differentiation; Embryonic stem cells; Epigenetics; Gene expression; H3K4me3; Histone demethylase; KDM5B; Pluripotent

Mesh：

Substances：

Year:  2018        PMID： 30448242      PMCID： PMC6522339          DOI： 10.1016/j.semcancer.2018.11.001

Source DB:  PubMed          Journal:  Semin Cancer Biol        ISSN： 1044-579X            Impact factor:   15.707


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