Irem Yıldırım Capraz1, Gökhan Kurt2, Özgür Akdemir3, Tugba Hirfanoglu4, Yusuf Oner5, Tugba Sengezer6, Lütfiye Ozlem Atay Kapucu3, Ayse Serdaroglu4, Erhan Bilir7. 1. Gazi University, Faculty of Medicine, Department of Neurology, Ankara, Turkey. Electronic address: driremyildirim@yahoo.com.tr. 2. Gazi University, Faculty of Medicine, Department of Neurosurgery, Ankara, Turkey. 3. Gazi University, Faculty of Medicine, Department of Nuclear Medicine, Ankara, Turkey. 4. Gazi University, Faculty of Medicine, Department of Pediatric Neurology, Ankara, Turkey. 5. Gazi University, Faculty of Medicine, Department of Radiology, Ankara, Turkey. 6. Guven Hospital, Department of Nuclear Medicine, Ankara, Turkey. 7. Gazi University, Faculty of Medicine, Department of Neurology, Ankara, Turkey.
Abstract
PURPOSE: The purpose of this study was to determine the long-term surgical outcomes of magnetic resonance imaging (MRI)-negative, fluorodeoxyglucose positron emission tomography (FDG-PET)-positive patients with temporal lobe epilepsy (TLE) and compare them with those of patients with mesial temporal sclerosis (MTS). METHODS: One hundred forty-one patients with TLE who underwent anterior temporal lobectomy were included in the study. The surgical outcomes of 24 patients with unilateral temporal hypometabolism on FDG-PET without an epileptogenic lesion on MRI were compared with that of patients with unilateral temporal hypometabolism on FDG-PET with MTS on MRI (n=117). The outcomes were compared using Engel's classification at 2 years after surgery. Clinical characteristics, unilateral interictal epileptiform discharges (IEDs), histopathological data and operation side were considered as probable prognostic factors. RESULTS: Class I surgical outcomes were similar in MRI-negative patients and the patients with MTS on MRI (seizure-free rate at postoperative 2 years was 79.2% and 82% in the MRI-negative and MTS groups, respectively). In univariate analysis, history of febrile convulsions, presence of unilateral IEDs and left temporal localization were found to be significantly associated with seizure free outcome. Multivariate analysis revealed that independent predictors of a good outcome were history of febrile convulsions and presence of unilateral IEDs. CONCLUSION: Our results suggest that epilepsy surgery outcomes of MRI-negative, PET positive patients are similar to those of patients with MTS. This finding may aid in the selection of best candidates for epilepsy surgery.
PURPOSE: The purpose of this study was to determine the long-term surgical outcomes of magnetic resonance imaging (MRI)-negative, fluorodeoxyglucose positron emission tomography (FDG-PET)-positive patients with temporal lobe epilepsy (TLE) and compare them with those of patients with mesial temporal sclerosis (MTS). METHODS: One hundred forty-one patients with TLE who underwent anterior temporal lobectomy were included in the study. The surgical outcomes of 24 patients with unilateral temporal hypometabolism on FDG-PET without an epileptogenic lesion on MRI were compared with that of patients with unilateral temporal hypometabolism on FDG-PET with MTS on MRI (n=117). The outcomes were compared using Engel's classification at 2 years after surgery. Clinical characteristics, unilateral interictal epileptiform discharges (IEDs), histopathological data and operation side were considered as probable prognostic factors. RESULTS: Class I surgical outcomes were similar in MRI-negative patients and the patients with MTS on MRI (seizure-free rate at postoperative 2 years was 79.2% and 82% in the MRI-negative and MTS groups, respectively). In univariate analysis, history of febrile convulsions, presence of unilateral IEDs and left temporal localization were found to be significantly associated with seizure free outcome. Multivariate analysis revealed that independent predictors of a good outcome were history of febrile convulsions and presence of unilateral IEDs. CONCLUSION: Our results suggest that epilepsy surgery outcomes of MRI-negative, PET positive patients are similar to those of patients with MTS. This finding may aid in the selection of best candidates for epilepsy surgery.
Authors: Sanam J Lalani; Anny Reyes; Erik Kaestner; Shauna M Stark; Craig E L Stark; David Lee; Leena Kansal; Jerry J Shih; Christine N Smith; Brianna M Paul; Carrie R McDonald Journal: J Int Neuropsychol Soc Date: 2021-06-03 Impact factor: 3.114