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Literature DB >> 26062982

Concise Review: Manufacturing of Pancreatic Endoderm Cells for Clinical Trials in Type 1 Diabetes.

Abstract

The cellular component of ViaCyte's VC-01 combination product for type 1 diabetes, pancreatic endoderm cells (PEC-01) derived from CyT49 human embryonic stem cells, matures after transplantation and functions to regulate blood glucose in rodent models. The aims in manufacturing PEC-01 at scale are to generate a consistent and robust transplantable population that functions reliably and safely in vivo. ViaCyte has integrated multiple bioprocessing strategies to enable a tightly controlled PEC-01 manufacturing process for clinical entry. ©AlphaMed Press.

Entities: Chemical Disease Species

Keywords: Cell differentiation; Embryonic stem cells; Endoderm; Pancreas

Mesh：

Substances：
Blood Glucose

Year: 2015 PMID： 26062982 PMCID： PMC4511151 DOI： 10.5966/sctm.2015-0058

Source DB: PubMed Journal: Stem Cells Transl Med ISSN： 2157-6564 Impact factor: 6.940

15 in total

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Authors: Ron C Gaba; Raquel Garcia-Roca; Jose Oberholzer
Journal: J Vasc Interv Radiol Date: 2012-03-13 Impact factor: 3.464

2. Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells.

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Journal: Nat Biotechnol Date: 2011-07-31 Impact factor: 54.908

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Authors: Alireza Rezania; Jennifer E Bruin; Payal Arora; Allison Rubin; Irina Batushansky; Ali Asadi; Shannon O'Dwyer; Nina Quiskamp; Majid Mojibian; Tobias Albrecht; Yu Hsuan Carol Yang; James D Johnson; Timothy J Kieffer
Journal: Nat Biotechnol Date: 2014-09-11 Impact factor: 54.908

4. Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape.

Authors: Kaitlyn Kirk; Ergeng Hao; Reyhaneh Lahmy; Pamela Itkin-Ansari
Journal: Stem Cell Res Date: 2014-03-24 Impact factor: 2.020

5. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo.

Authors: Evert Kroon; Laura A Martinson; Kuniko Kadoya; Anne G Bang; Olivia G Kelly; Susan Eliazer; Holly Young; Mike Richardson; Nora G Smart; Justine Cunningham; Alan D Agulnick; Kevin A D'Amour; Melissa K Carpenter; Emmanuel E Baetge
Journal: Nat Biotechnol Date: 2008-02-20 Impact factor: 54.908

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Authors: Felicia W Pagliuca; Jeffrey R Millman; Mads Gürtler; Michael Segel; Alana Van Dervort; Jennifer Hyoje Ryu; Quinn P Peterson; Dale Greiner; Douglas A Melton
Journal: Cell Date: 2014-10-09 Impact factor: 41.582

7. Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3.

Authors: Barak Blum; Siniša Hrvatin; Christian Schuetz; Claire Bonal; Alireza Rezania; Douglas A Melton
Journal: Nat Biotechnol Date: 2012-02-26 Impact factor: 54.908

8. Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice.

Authors: Alireza Rezania; Jennifer E Bruin; Michael J Riedel; Majid Mojibian; Ali Asadi; Jean Xu; Rebecca Gauvin; Kavitha Narayan; Francis Karanu; John J O'Neil; Ziliang Ao; Garth L Warnock; Timothy J Kieffer
Journal: Diabetes Date: 2012-06-27 Impact factor: 9.337

9. Advances and challenges in islet transplantation: islet procurement rates and lessons learned from suboptimal islet transplantation.

Authors: Annette Plesner; C Bruce Verchere
Journal: J Transplant Date: 2011-12-22

10. Treatment of diabetic rats with encapsulated islets.

Authors: Ian R Sweet; Ofer Yanay; Lanaya Waldron; Merle Gilbert; Jessica M Fuller; Terry Tupling; Ake Lernmark; William R A Osborne
Journal: J Cell Mol Med Date: 2008-03-28 Impact factor: 5.310

27 in total

Review 1. The Nexus of Stem Cell-Derived Beta-Cells and Genome Engineering.

Authors: Sara D Sackett; Aida Rodriguez; Jon S Odorico
Journal: Rev Diabet Stud Date: 2017-06-12

2. Utilizing FUCCI reporters to understand pluripotent stem cell biology.

Authors: Amar M Singh; Robert Trost; Benjamin Boward; Stephen Dalton
Journal: Methods Date: 2015-09-21 Impact factor: 3.608

Review 3. Manufacturing Cell Therapies Using Engineered Biomaterials.

Authors: Amr A Abdeen; Krishanu Saha
Journal: Trends Biotechnol Date: 2017-07-12 Impact factor: 19.536

Review 4. Pluripotent stem cells progressing to the clinic.

Authors: Alan Trounson; Natalie D DeWitt
Journal: Nat Rev Mol Cell Biol Date: 2016-03 Impact factor: 94.444

5. Glucocorticoid Signaling Enhances Expression of Glucose-Sensing Molecules in Immature Pancreatic Beta-Like Cells Derived from Murine Embryonic Stem Cells In Vitro.

Authors: Nadiah Ghazalli; Xiaoxing Wu; Stephanie Walker; Nancy Trieu; Li-Yu Hsin; Justin Choe; Chialin Chen; Jasper Hsu; Jeanne LeBon; Mark T Kozlowski; Jeffrey Rawson; David A Tirrell; M L Richard Yip; Hsun Teresa Ku
Journal: Stem Cells Dev Date: 2018-06-06 Impact factor: 3.272