Literature DB >> 22371083

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3.

Barak Blum1, Siniša Hrvatin, Christian Schuetz, Claire Bonal, Alireza Rezania, Douglas A Melton.   

Abstract

Insulin-expressing cells that have been differentiated from human pluripotent stem cells in vitro lack the glucose responsiveness characteristic of mature beta cells. Beta-cell maturation in mice was studied to find genetic markers that enable screens for factors that induce bona fide beta cells in vitro. We find that functional beta-cell maturation is marked by an increase in the glucose threshold for insulin secretion and by expression of the gene urocortin 3.

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Year:  2012        PMID： 22371083      PMCID： PMC4617627          DOI： 10.1038/nbt.2141

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


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