Naziha Khen-Dunlop1,2, Myriam Dabbas3, Gianpaolo De Filippo4, Jean-Philippe Jais5,6, Erik Hervieux7, Caroline Télion8, Jean-Marc Chevallier9, Jean-Luc Michel10, Yves Aigrain11,12, Pierre Bougnères13, Olivier Goulet14,15, Yann Révillon16,17. 1. AP-HP, Hôpital Necker-Enfants Malades, Service de Chirurgie Pédiatrique Viscérale, 149 rue de Sevres, 75015, Paris, France. naziha.khen-dunlop@nck.aphp.fr. 2. Université Paris Descartes, Paris, France. naziha.khen-dunlop@nck.aphp.fr. 3. AP-HP, Hôpital Necker-Enfants malades, Service de Gastroenterologie et Nutrition Pédiatrique, Paris, France. Myriam.dabbas@nck.aphp.fr. 4. AP-HP, Hôpital Bicêtre, Unité Médico-chirurgicale Obésité de l'Adolescent, Service de Médecine des Adolescents, Le Kremlin Bicêtre, France. gianpaolo.defilipo@bct.aphp.fr. 5. AP-HP, Hôpital Necker-Enfants Malades, Département de Biostatistiques, Paris, France. jean-philippe.jais@nck.aphp.fr. 6. Université Paris Descartes, Paris, France. jean-philippe.jais@nck.aphp.fr. 7. AP-HP, Hôpital Necker-Enfants Malades, Service de Chirurgie Pédiatrique Viscérale, 149 rue de Sevres, 75015, Paris, France. erik.hervieux@nck.aphp.fr. 8. AP-HP, Hôpital Necker-Enfants Malades, Départment d'Anesthésie et Réanimation, Paris, France. caroline.telion@nck.aphp.fr. 9. AP-HP, Hôpital Européen Georges Pompidou, Service de Chirurgie Générale, Paris, France. jean-marc.chevallier@egp.aphp.fr. 10. AP-HP, Hôpital Necker-Enfants Malades, Service de Chirurgie Pédiatrique Viscérale, 149 rue de Sevres, 75015, Paris, France. jean-luc.michel@chu-reunion.fr. 11. AP-HP, Hôpital Necker-Enfants Malades, Service de Chirurgie Pédiatrique Viscérale, 149 rue de Sevres, 75015, Paris, France. yves.aigrain@nck.aphp.fr. 12. Université Paris Descartes, Paris, France. yves.aigrain@nck.aphp.fr. 13. AP-HP, Hôpital Bicêtre, Service d'Endocrinologie et Diabétologie Pédiatrique, Le Kremlin Bicêtre, France. pierre.bougneres@inserm.fr. 14. AP-HP, Hôpital Necker-Enfants malades, Service de Gastroenterologie et Nutrition Pédiatrique, Paris, France. olivier.goulet@nck.aphp.fr. 15. Université Paris Descartes, Paris, France. olivier.goulet@nck.aphp.fr. 16. AP-HP, Hôpital Necker-Enfants Malades, Service de Chirurgie Pédiatrique Viscérale, 149 rue de Sevres, 75015, Paris, France. yann.revillon@nck.aphp.fr. 17. Université Paris Descartes, Paris, France. yann.revillon@nck.aphp.fr.
Abstract
BACKGROUND: Accumulating evidence suggests that the benefits seen in adult bariatric surgery can be reproduced in adolescents. In contrast with North America, bariatric surgery in adolescents is still not well accepted in Europe and indications and protocols have still to be formulated. METHODS: This prospective study tested the gastric banding procedure in 49 patients operated in a single French institution since 2008. The mean age at surgery was 16.2 ± 0.9 years with a weight of 118.8 ± 22.3 kg and body mass index of 42.5 ± 5.9 kg/m(2). RESULTS: At 6, 12 and 24 months after surgery, weight was 103.7 ± 20.8 kg, 98.7 ± 21 kg and 93.6 ± 19.3 kg, respectively (p < 0.001), corresponding to excess weight loss (EWL) of 31.6 ± 17.2 %, 41.8 ± 21.4 % and 59.1 ± 24.9 % (p < 0.001), respectively. Multivariate analysis showed that the number of consultations per year was the only variable significantly associated to weight loss. Metabolic disorders were corrected, with a decreased prevalence of insulin resistance from 100 to 17 % and normalisation of homeostasis model assessment-insulin resistance (HOMA-IR) at 24 months (2.09 ± 0.95). Band-related complications were five slippages, one psychological intolerance and two ports repositioning. Six patients (12 %) had the device explanted. The death of a patient was an exceptionally severe adverse event. CONCLUSION: Given frequent follow-up support by a multidisciplinary team, laparoscopic adjustable gastric banding (LAGB) surgery in adolescent results in sustained weight loss. However, even exceptional, potentially serious complications are possible and long-term follow-up is needed to evaluate the risk/benefit ratio at 5 or 10 years after LAGB surgery.
BACKGROUND: Accumulating evidence suggests that the benefits seen in adult bariatric surgery can be reproduced in adolescents. In contrast with North America, bariatric surgery in adolescents is still not well accepted in Europe and indications and protocols have still to be formulated. METHODS: This prospective study tested the gastric banding procedure in 49 patients operated in a single French institution since 2008. The mean age at surgery was 16.2 ± 0.9 years with a weight of 118.8 ± 22.3 kg and body mass index of 42.5 ± 5.9 kg/m(2). RESULTS: At 6, 12 and 24 months after surgery, weight was 103.7 ± 20.8 kg, 98.7 ± 21 kg and 93.6 ± 19.3 kg, respectively (p < 0.001), corresponding to excess weight loss (EWL) of 31.6 ± 17.2 %, 41.8 ± 21.4 % and 59.1 ± 24.9 % (p < 0.001), respectively. Multivariate analysis showed that the number of consultations per year was the only variable significantly associated to weight loss. Metabolic disorders were corrected, with a decreased prevalence of insulin resistance from 100 to 17 % and normalisation of homeostasis model assessment-insulin resistance (HOMA-IR) at 24 months (2.09 ± 0.95). Band-related complications were five slippages, one psychological intolerance and two ports repositioning. Six patients (12 %) had the device explanted. The death of a patient was an exceptionally severe adverse event. CONCLUSION: Given frequent follow-up support by a multidisciplinary team, laparoscopic adjustable gastric banding (LAGB) surgery in adolescent results in sustained weight loss. However, even exceptional, potentially serious complications are possible and long-term follow-up is needed to evaluate the risk/benefit ratio at 5 or 10 years after LAGB surgery.
Entities:
Keywords:
Adolescent; Bariatric surgery; Complications; LAGB; Obesity; Paediatrics; Results; Teen
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