Lindel C Dewberry1, Anahita Jalivand2, Resmi Gupta3, Todd M Jenkins3, Andrew Beamish4, Thomas H Inge1, Anita Courcoulas5, Michael Helmrath3, Mary L Brandt6, Carroll M Harmon7, Mike Chen8, John B Dixon9, Margaret Zeller3, Marc P Michalsky10. 1. Children's Hospital Colorado, Aurora, CO, USA. 2. The Ohio State University-Wexner Medical Center, Columbus, OH, USA. 3. Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. 4. Royal College of Surgeons of England, London, UK. 5. University of Pittsburgh Medical Center, Pittsburgh, PA, USA. 6. Texas Children's Hospital, Houston, TX, USA. 7. Women and Children's Hospital of Buffalo, Buffalo, NY, USA. 8. University of Alabama at Birmingham, Birmingham, AL, USA. 9. Baker Heart and Diabetes Institute, Melbourne, Australia. 10. Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA. marc.michalsky@nationwidechildrens.org.
Abstract
OBJECTIVE: This prospective cohort analysis describes changes in weight, cardiometabolic health, and weight-related quality of life (WRQOL) following adolescent LAGB. METHODS: Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) collected demographic, anthropometric, micronutrient, cardiometabolic risk, and WRQOL data for 242 adolescents. Data through 5 years were analyzed for 14 participants who underwent LAGB with 2 patients lost to follow-up. RESULTS: Participants (mean age 18.2 ± 0.4 years) were mostly female (86%) and white (71%) with a median body mass index (BMI) of 48.7 kg/m2 (45.5-54.1). Preoperatively, 100%(13/13), 62%(8/13), 57%(8/14), and 7%(1/14) had elevated high sensitivity C-reactive protein (hs-CRP), dyslipidemia, elevated blood pressure (EBP), and type 2 diabetes (T2D), respectively. At 5 years, mean BMI decreased by 3.3% (51.0 vs. 49.3 kg/m2, p = 0.6), 43%(6/14) had BMI values exceeding baseline and 21% (3/14) underwent band removal. Postoperative prevalence of hs-CRP, dyslipidemia, EBP, and T2D was 45% (4/11), 36% (5/11), 33% (4/12), and 0% (0/11), respectively. CONCLUSION: Adolescents undergoing LAGB experienced modest initial weight loss and improvements in cardiovascular risk factors with later weight regain and frequent need for band removal. Despite the small sample size, this prospective study highlights long-term outcomes with high rates of participant retention over time. CLINICAL TRIAL REGISTRATION: NCT00465829.
OBJECTIVE: This prospective cohort analysis describes changes in weight, cardiometabolic health, and weight-related quality of life (WRQOL) following adolescent LAGB. METHODS: Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) collected demographic, anthropometric, micronutrient, cardiometabolic risk, and WRQOL data for 242 adolescents. Data through 5 years were analyzed for 14 participants who underwent LAGB with 2 patients lost to follow-up. RESULTS:Participants (mean age 18.2 ± 0.4 years) were mostly female (86%) and white (71%) with a median body mass index (BMI) of 48.7 kg/m2 (45.5-54.1). Preoperatively, 100%(13/13), 62%(8/13), 57%(8/14), and 7%(1/14) had elevated high sensitivity C-reactive protein (hs-CRP), dyslipidemia, elevated blood pressure (EBP), and type 2 diabetes (T2D), respectively. At 5 years, mean BMI decreased by 3.3% (51.0 vs. 49.3 kg/m2, p = 0.6), 43%(6/14) had BMI values exceeding baseline and 21% (3/14) underwent band removal. Postoperative prevalence of hs-CRP, dyslipidemia, EBP, and T2D was 45% (4/11), 36% (5/11), 33% (4/12), and 0% (0/11), respectively. CONCLUSION: Adolescents undergoing LAGB experienced modest initial weight loss and improvements in cardiovascular risk factors with later weight regain and frequent need for band removal. Despite the small sample size, this prospective study highlights long-term outcomes with high rates of participant retention over time. CLINICAL TRIAL REGISTRATION: NCT00465829.
Entities:
Keywords:
Adjustable gastric band; Adolescent; Bariatric surgery
Authors: Stavra A Xanthakos; Todd M Jenkins; David E Kleiner; Tawny W Boyce; Reena Mourya; Rebekah Karns; Mary L Brandt; Carroll M Harmon; Michael A Helmrath; Marc P Michalsky; Anita P Courcoulas; Meg H Zeller; Thomas H Inge Journal: Gastroenterology Date: 2015-05-28 Impact factor: 22.682
Authors: Thomas H Inge; Anita P Courcoulas; Todd M Jenkins; Marc P Michalsky; Michael A Helmrath; Mary L Brandt; Carroll M Harmon; Meg H Zeller; Mike K Chen; Stavra A Xanthakos; Mary Horlick; C Ralph Buncher Journal: N Engl J Med Date: 2015-11-06 Impact factor: 91.245
Authors: Gilad Twig; Gal Yaniv; Hagai Levine; Adi Leiba; Nehama Goldberger; Estela Derazne; Dana Ben-Ami Shor; Dorit Tzur; Arnon Afek; Ari Shamiss; Ziona Haklai; Jeremy D Kark Journal: N Engl J Med Date: 2016-04-13 Impact factor: 91.245
Authors: Thomas H Inge; Todd M Jenkins; Stavra A Xanthakos; John B Dixon; Stephen R Daniels; Meg H Zeller; Michael A Helmrath Journal: Lancet Diabetes Endocrinol Date: 2017-01-06 Impact factor: 32.069
Authors: Torsten Olbers; Andrew J Beamish; Eva Gronowitz; Carl-Erik Flodmark; Jovanna Dahlgren; Gustaf Bruze; Kerstin Ekbom; Peter Friberg; Gunnar Göthberg; Kajsa Järvholm; Jan Karlsson; Staffan Mårild; Martin Neovius; Markku Peltonen; Claude Marcus Journal: Lancet Diabetes Endocrinol Date: 2017-01-06 Impact factor: 32.069