Literature DB >> 26052790

Environmental enrichment as a therapy for autism: A clinical trial replication and extension.

Cynthia C Woo1, Joseph H Donnelly2, Robin Steinberg-Epstein2, Michael Leon1.   

Abstract

Based on work done in animal models showing that autism-like symptoms are ameliorated following exposure to an enriched sensorimotor environment, we attempted to develop a comparable therapy for children with autism. In an initial randomized controlled trial, children with autism who received sensorimotor enrichment at home for 6 months had significant improvements in both their cognitive ability and the severity of their autism symptoms (Woo & Leon, 2013). We now report the outcomes of a similar randomized controlled trial in which children with autism, 3 to 6 years old, were randomly assigned to groups that received either daily sensorimotor enrichment, administered by their parents, along with standard care, or they received standard care alone. After 6 months, enriched children showed statistically significant gains in their IQ scores, a decline in their atypical sensory responses, and an improvement in their receptive language performance, compared to controls. Furthermore, after 6 months of enrichment therapy, 21% of the children who initially had been given an autism classification, using the Autism Diagnostic Observation Schedule, improved to the point that, although they remained on the autism spectrum, they no longer met the criteria for classic autism. None of the standard care controls reached an equivalent level of improvement. Finally, the outcome measures for children who received only a subset of sensory stimuli were similar to those receiving the full complement of enrichment exercises. Sensorimotor enrichment therapy therefore appears to be a cost-effective means of treating a range of symptoms for children with autism. (c) 2015 APA, all rights reserved).

Entities:  

Mesh:

Year:  2015        PMID: 26052790      PMCID: PMC4682896          DOI: 10.1037/bne0000068

Source DB:  PubMed          Journal:  Behav Neurosci        ISSN: 0735-7044            Impact factor:   1.912


  62 in total

Review 1.  Sensory integration therapies for children with developmental and behavioral disorders.

Authors:  Michelle Zimmer; Larry Desch
Journal:  Pediatrics       Date:  2012-05-28       Impact factor: 7.124

2.  Effectiveness of sensory integration interventions in children with autism spectrum disorders: a pilot study.

Authors:  Beth A Pfeiffer; Kristie Koenig; Moya Kinnealey; Megan Sheppard; Lorrie Henderson
Journal:  Am J Occup Ther       Date:  2011 Jan-Feb

3.  Enriched rearing improves behavioral responses of an animal model for CNV-based autistic-like traits.

Authors:  Melanie Lacaria; Corinne Spencer; Wenli Gu; Richard Paylor; James R Lupski
Journal:  Hum Mol Genet       Date:  2012-04-05       Impact factor: 6.150

Review 4.  Diagnostic procedures in autism spectrum disorders: a systematic literature review.

Authors:  Torbjörn Falkmer; Katie Anderson; Marita Falkmer; Chiara Horlin
Journal:  Eur Child Adolesc Psychiatry       Date:  2013-01-16       Impact factor: 4.785

5.  Environmental enrichment alters locomotor behaviour and ventricular volume in Mecp2 1lox mice.

Authors:  Nupur Nag; Jennifer M Moriuchi; Cassandra G K Peitzman; Bonnie C Ward; Nancy H Kolodny; Joanne E Berger-Sweeney
Journal:  Behav Brain Res       Date:  2008-07-18       Impact factor: 3.332

6.  Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism.

Authors:  Tomasz Schneider; Ryszard Przewłocki
Journal:  Neuropsychopharmacology       Date:  2005-01       Impact factor: 7.853

7.  The effects of improvisational music therapy on joint attention behaviors in autistic children: a randomized controlled study.

Authors:  Jinah Kim; Tony Wigram; Christian Gold
Journal:  J Autism Dev Disord       Date:  2008-07-01

8.  Sensory responsiveness as a predictor of social severity in children with high functioning autism spectrum disorders.

Authors:  Claudia L Hilton; Jacquelyn D Harper; Rachel Holmes Kueker; Andrea Runzi Lang; Anna M Abbacchi; Alexandre Todorov; Patricia D LaVesser
Journal:  J Autism Dev Disord       Date:  2010-08

9.  Exploratory study describing 6 month outcomes for young children with autism who receive treatment as usual in Italy.

Authors:  Filippo Muratori; Antonio Narzisi
Journal:  Neuropsychiatr Dis Treat       Date:  2014-04-08       Impact factor: 2.570

10.  An intervention for sensory difficulties in children with autism: a randomized trial.

Authors:  Roseann C Schaaf; Teal Benevides; Zoe Mailloux; Patricia Faller; Joanne Hunt; Elke van Hooydonk; Regina Freeman; Benjamin Leiby; Jocelyn Sendecki; Donna Kelly
Journal:  J Autism Dev Disord       Date:  2014-07
View more
  27 in total

1.  How does environmental enrichment reduce repetitive motor behaviors? Neuronal activation and dendritic morphology in the indirect basal ganglia pathway of a mouse model.

Authors:  Allison R Bechard; Nadia Cacodcar; Michael A King; Mark H Lewis
Journal:  Behav Brain Res       Date:  2015-11-24       Impact factor: 3.332

2.  Transgenerational effects of environmental enrichment on repetitive motor behavior development.

Authors:  Allison R Bechard; Mark H Lewis
Journal:  Behav Brain Res       Date:  2016-04-06       Impact factor: 3.332

3.  Environmental enrichment improves metabolic and behavioral health in the BTBR mouse model of autism.

Authors:  Nicholas J Queen; Amber A Boardman; Ripal S Patel; Jason J Siu; Xiaokui Mo; Lei Cao
Journal:  Psychoneuroendocrinology       Date:  2019-10-15       Impact factor: 4.905

Review 4.  Resilience priming: Translational models for understanding resiliency and adaptation to early life adversity.

Authors:  Amanda C Kentner; John F Cryan; Susanne Brummelte
Journal:  Dev Psychobiol       Date:  2018-10-11       Impact factor: 3.038

5.  Intervention Effects on Language in Children With Autism: A Project AIM Meta-Analysis.

Authors:  Micheal Sandbank; Kristen Bottema-Beutel; Shannon Crowley; Margaret Cassidy; Jacob I Feldman; Marcos Canihuante; Tiffany Woynaroski
Journal:  J Speech Lang Hear Res       Date:  2020-05-08       Impact factor: 2.297

6.  Environmental Enrichment Mitigates Deficits after Repetitive Mild Traumatic Brain Injury.

Authors:  Xixia Liu; Jianhua Qiu; Sasha Alcon; Jumana Hashim; William P Meehan; Rebekah Mannix
Journal:  J Neurotrauma       Date:  2017-06-08       Impact factor: 5.269

7.  Access to a high resource environment protects against accelerated maturation following early life stress: A translational animal model of high, medium and low security settings.

Authors:  Arielle R Strzelewicz; Evelyn Ordoñes Sanchez; Alejandro N Rondón-Ortiz; Anthony Raneri; Sydney T Famularo; Debra A Bangasser; Amanda C Kentner
Journal:  Horm Behav       Date:  2019-03-02       Impact factor: 3.587

8.  Project AIM: Autism intervention meta-analysis for studies of young children.

Authors:  Micheal Sandbank; Kristen Bottema-Beutel; Shannon Crowley; Margaret Cassidy; Kacie Dunham; Jacob I Feldman; Jenna Crank; Susanne A Albarran; Sweeya Raj; Prachy Mahbub; Tiffany G Woynaroski
Journal:  Psychol Bull       Date:  2019-11-25       Impact factor: 17.737

9.  Poly (I:C)-induced maternal immune activation modifies ventral hippocampal regulation of stress reactivity: prevention by environmental enrichment.

Authors:  Xin Zhao; Ruqayah Mohammed; Hieu Tran; Mary Erickson; Amanda C Kentner
Journal:  Brain Behav Immun       Date:  2021-03-23       Impact factor: 19.227

10.  Enriched gardens improve cognition and independence of nursing home residents with dementia: a pilot controlled trial.

Authors:  Etienne Bourdon; Joël Belmin
Journal:  Alzheimers Res Ther       Date:  2021-06-16       Impact factor: 6.982

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.