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Literature DB >> 2604733

The analysis of metabolite channelling in multienzyme complexes and multifunctional proteins.

Abstract

Multienzyme complexes and multifunctional proteins may confer a kinetic advantage by channelling reaction intermediates between consecutive enzymes and reducing the transient time for the establishment of steady states. A general means for quantitatively assessing the contribution of channelling to the reduction of pool size and transient time is presented. Restrictions to the kinetic advantage are identified, and it is shown that no channelling advantage is obtained at high enzyme concentration or for enzymes which exhibit rapid-equilibrium kinetic behaviour.

Mesh：

Substances：
Multienzyme Complexes

Year: 1989 PMID： 2604733 PMCID： PMC1133622 DOI： 10.1042/bj2640605

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

11 in total

1. Coordinate activation of a multienzyme complex by the first substrate. Evidence for a novel regulatory mechanism in the polyaromatic pathway of Neurospora crassa.

Authors: G R Welch; F H Gaertner
Journal: Arch Biochem Biophys Date: 1976-02 Impact factor: 4.013

2. Properties of a multimeric protein complex from chloroplasts possessing potential activities of NADPH-dependent glyceraldehyde-3-phosphate dehydrogenase and phosphoribulokinase.

Authors: S Nicholson; J S Easterby; R Powls
Journal: Eur J Biochem Date: 1987-01-15

3. Transient-time analysis of substrate-channelling in interacting enzyme systems.

Authors: J Ovádi; P Tompa; B Vértessy; F Orosz; T Keleti; G R Welch
Journal: Biochem J Date: 1989-01-01 Impact factor: 3.857

4. The effect of feedback on pathway transient response.

Authors: J S Easterby
Journal: Biochem J Date: 1986-02-01 Impact factor: 3.857

5. Indole channeling by tryptophan synthase of neurospora.

Authors: W H Matchett
Journal: J Biol Chem Date: 1974-07-10 Impact factor: 5.157

Review 6. Enzyme-enzyme interactions and the regulation of metabolic reaction pathways.

Authors: D K Srivastava; S A Bernhard
Journal: Curr Top Cell Regul Date: 1986

7. A functional five-enzyme complex of chloroplasts involved in the Calvin cycle.

Authors: B Gontero; M L Cárdenas; J Ricard
Journal: Eur J Biochem Date: 1988-04-15

8. Multienzymatic proteins in mammalian pyrimidine biosynthesis: channeling of intermediates to avoid futile cycles.

Authors: R I Christopherson; T W Traut; M E Jones
Journal: Curr Top Cell Regul Date: 1981

9. A generalized theory of the transition time for sequential enzyme reactions.

Authors: J S Easterby
Journal: Biochem J Date: 1981-10-01 Impact factor: 3.857

10. The overall synthesis of L-5,6-dihydroorotate by multienzymatic protein pyr1-3 from hamster cells. Kinetic studies, substrate channeling, and the effects of inhibitors.

Authors: R I Christopherson; M E Jones
Journal: J Biol Chem Date: 1980-12-10 Impact factor: 5.157

8 in total

1. Control analysis of transition times. Extension of analysis and matrix method.

Authors: M Cascante; N V Torres; R Franco; E Meléndez-Hevia; E I Canela
Journal: Mol Cell Biochem Date: 1991-02-27 Impact factor: 3.396

2. Effect of channelling on the concentration of bulk-phase intermediates as cytosolic proteins become more concentrated.

Authors: B N Kholodenko; H V Westerhoff; M Cascante
Journal: Biochem J Date: 1996-02-01 Impact factor: 3.857

The analysis of metabolite channelling in multienzyme complexes and multifunctional proteins.

1. Coordinate activation of a multienzyme complex by the first substrate. Evidence for a novel regulatory mechanism in the polyaromatic pathway of Neurospora crassa.

2. Properties of a multimeric protein complex from chloroplasts possessing potential activities of NADPH-dependent glyceraldehyde-3-phosphate dehydrogenase and phosphoribulokinase.

3. Transient-time analysis of substrate-channelling in interacting enzyme systems.

4. The effect of feedback on pathway transient response.

5. Indole channeling by tryptophan synthase of neurospora.

Review 6. Enzyme-enzyme interactions and the regulation of metabolic reaction pathways.

7. A functional five-enzyme complex of chloroplasts involved in the Calvin cycle.

8. Multienzymatic proteins in mammalian pyrimidine biosynthesis: channeling of intermediates to avoid futile cycles.

9. A generalized theory of the transition time for sequential enzyme reactions.

10. The overall synthesis of L-5,6-dihydroorotate by multienzymatic protein pyr1-3 from hamster cells. Kinetic studies, substrate channeling, and the effects of inhibitors.

1. Control analysis of transition times. Extension of analysis and matrix method.

2. Effect of channelling on the concentration of bulk-phase intermediates as cytosolic proteins become more concentrated.

3. Enzyme-enzyme interactions and metabolite channelling: alternative mechanisms and their evolutionary significance.

Review 4. Metabolic channeling: predictions, deductions, and evidence.

5. Direct observation of hexokinase translocation in stimulated macrophages.

Review 6. Evolution of Enzyme Kinetic Mechanisms.

Review 7. Regulation of mammalian nucleotide metabolism and biosynthesis.

Review 8. The structural and functional coordination of glycolytic enzymes in muscle: evidence of a metabolon?