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Literature DB >> 26625014

RNA epigenetics--chemical messages for posttranscriptional gene regulation.

Abstract

Chemical modifications in cellular RNA are diverse and abundant. Commonly found in ribosomal RNA (rRNA), transfer RNA (tRNA), long-noncoding RNA (lncRNA), and small nuclear (snRNA), these components play various structural and functional roles. Until recently, the roles of chemical modifications within messenger RNA (mRNA) have been understudied. Recent maps of several mRNA modifications have suggested regulatory functions for these marks. This review summarizes recent advances in identifying and understanding biological roles of posttranscriptional mRNA modification, or 'RNA epigenetics', with an emphasis on the most common internal modification of eukaryotic mRNA, N(6)-methyladenosine (m(6)A). We also discuss YTH proteins as direct mediators of m(6)A function and the emerging role of this mark in a new layer of gene expression regulation. Published by Elsevier Ltd.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
RNA, Messenger

Year: 2015 PMID： 26625014 PMCID： PMC4731286 DOI： 10.1016/j.cbpa.2015.10.024

Source DB: PubMed Journal: Curr Opin Chem Biol ISSN： 1367-5931 Impact factor: 8.822

47 in total

1. Methylated simian virus 40-specific RNA from nuclei and cytoplasm of infected BSC-1 cells.

Authors: S Lavi; A J Shatkin
Journal: Proc Natl Acad Sci U S A Date: 1975-06 Impact factor: 11.205

2. N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.

Authors: Xiao Wang; Boxuan Simen Zhao; Ian A Roundtree; Zhike Lu; Dali Han; Honghui Ma; Xiaocheng Weng; Kai Chen; Hailing Shi; Chuan He
Journal: Cell Date: 2015-06-04 Impact factor: 41.582

3. m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells.

Authors: Pedro J Batista; Benoit Molinie; Jinkai Wang; Kun Qu; Jiajing Zhang; Lingjie Li; Donna M Bouley; Ernesto Lujan; Bahareh Haddad; Kaveh Daneshvar; Ava C Carter; Ryan A Flynn; Chan Zhou; Kok-Seong Lim; Peter Dedon; Marius Wernig; Alan C Mullen; Yi Xing; Cosmas C Giallourakis; Howard Y Chang
Journal: Cell Stem Cell Date: 2014-10-16 Impact factor: 24.633

4. Molecular basis for the recognition of methylated adenines in RNA by the eukaryotic YTH domain.

Authors: Shukun Luo; Liang Tong
Journal: Proc Natl Acad Sci U S A Date: 2014-09-08 Impact factor: 11.205

5. Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain.

Authors: Chao Xu; Xiao Wang; Ke Liu; Ian A Roundtree; Wolfram Tempel; Yanjun Li; Zhike Lu; Chuan He; Jinrong Min
Journal: Nat Chem Biol Date: 2014-09-21 Impact factor: 15.040

6. High-resolution N(6) -methyladenosine (m(6) A) map using photo-crosslinking-assisted m(6) A sequencing.

Authors: Kai Chen; Zhike Lu; Xiao Wang; Ye Fu; Guan-Zheng Luo; Nian Liu; Dali Han; Dan Dominissini; Qing Dai; Tao Pan; Chuan He
Journal: Angew Chem Int Ed Engl Date: 2014-12-09 Impact factor: 15.336

7. Adenosine Methylation in Arabidopsis mRNA is Associated with the 3' End and Reduced Levels Cause Developmental Defects.

Authors: Zsuzsanna Bodi; Silin Zhong; Surbhi Mehra; Jie Song; Neil Graham; Hongying Li; Sean May; Rupert George Fray
Journal: Front Plant Sci Date: 2012-03-23 Impact factor: 5.753

8. Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome.

Authors: Bastian Linder; Anya V Grozhik; Anthony O Olarerin-George; Cem Meydan; Christopher E Mason; Samie R Jaffrey
Journal: Nat Methods Date: 2015-06-29 Impact factor: 28.547

9. Transcriptome-wide N⁶-methyladenosine profiling of rice callus and leaf reveals the presence of tissue-specific competitors involved in selective mRNA modification.

Authors: Yuli Li; Xiliang Wang; Cuiping Li; Songnian Hu; Jun Yu; Shuhui Song
Journal: RNA Biol Date: 2014 Impact factor: 4.652

10. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.

Authors: Dan Dominissini; Sharon Moshitch-Moshkovitz; Schraga Schwartz; Mali Salmon-Divon; Lior Ungar; Sivan Osenberg; Karen Cesarkas; Jasmine Jacob-Hirsch; Ninette Amariglio; Martin Kupiec; Rotem Sorek; Gideon Rechavi
Journal: Nature Date: 2012-04-29 Impact factor: 49.962

54 in total

Review 1. Chemical and structural effects of base modifications in messenger RNA.

Authors: Emily M Harcourt; Anna M Kietrys; Eric T Kool
Journal: Nature Date: 2017-01-18 Impact factor: 49.962

Review 2. Detecting RNA modifications in the epitranscriptome: predict and validate.

Authors: Mark Helm; Yuri Motorin
Journal: Nat Rev Genet Date: 2017-02-20 Impact factor: 53.242

3. PROBer Provides a General Toolkit for Analyzing Sequencing-Based Toeprinting Assays.

Authors: Bo Li; Akshay Tambe; Sharon Aviran; Lior Pachter
Journal: Cell Syst Date: 2017-05-10 Impact factor: 10.304

4. Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution.

Authors: Jingyi Fei; Mahdieh Jadaliha; Tyler S Harmon; Isaac T S Li; Boyang Hua; Qinyu Hao; Alex S Holehouse; Matthew Reyer; Qinyu Sun; Susan M Freier; Rohit V Pappu; Kannanganattu V Prasanth; Taekjip Ha
Journal: J Cell Sci Date: 2017-11-13 Impact factor: 5.285

5. A novel malic acid-enhanced method for the analysis of 5-methyl-2'-deoxycytidine, 5-hydroxymethyl-2'-deoxycytidine, 5-methylcytidine and 5-hydroxymethylcytidine in human urine using hydrophilic interaction liquid chromatography-tandem mass spectrometry.

Authors: Cheng Guo; Cong Xie; Qin Chen; Xiaoji Cao; Mengzhe Guo; Shu Zheng; Yinsheng Wang
Journal: Anal Chim Acta Date: 2018-07-03 Impact factor: 6.558

10. In Vitro and In Vivo Enzyme Activity Screening via RNA-Based Fluorescent Biosensors for S-Adenosyl-l-homocysteine (SAH).

Authors: Yichi Su; Scott F Hickey; Samantha G L Keyser; Ming C Hammond
Journal: J Am Chem Soc Date: 2016-05-27 Impact factor: 15.419