Literature DB >> 2604547

Heterogeneity of the ARV-2 strain and natural isolates of the human immunodeficiency virus.

A F Etkin1, M I Bukrinsky.   

Abstract

To study heterogeneity of HIV isolates ARV-2 and strains isolated from lymphocytes of asymptomatic carriers were cloned using limiting dilutions of virus and infected CEM cells. All viral stocks turned out to be biologically heterogeneous giving clones with cytotoxic and noncytotoxic type of infection. Coinfection of CEM cells with cytotoxic and noncytotoxic variants resulted in interference of their biological effects. This interference ended with distinct cytotoxicity. No correlation between the production of virus and the amount of HIV DNA was found pointing out that nonfunctional DNA copies exist.

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Year:  1989        PMID： 2604547     DOI： 10.1007/bf01310939

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  16 in total

1.  Differential susceptibility of human lymphocyte cultures to infection by HIV.

Authors:  M A Wainberg; N Blain; L Fitz-Gibbon
Journal:  Clin Exp Immunol       Date:  1987-10       Impact factor: 4.330

2.  Differential response to the cytopathic effects of human T-cell lymphotropic virus type III (HTLV-III) superinfection in T4+ (helper) and T8+ (suppressor) T-cell clones transformed by HTLV-I.

Authors:  A De Rossi; G Franchini; A Aldovini; A Del Mistro; L Chieco-Bianchi; R C Gallo; F Wong-Staal
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

3.  Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS.

Authors:  B R Starcich; B H Hahn; G M Shaw; P D McNeely; S Modrow; H Wolf; E S Parks; W P Parks; S F Josephs; R C Gallo
Journal:  Cell       Date:  1986-06-06       Impact factor: 41.582

4.  Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2).

Authors:  R Sanchez-Pescador; M D Power; P J Barr; K S Steimer; M M Stempien; S L Brown-Shimer; W W Gee; A Renard; A Randolph; J A Levy
Journal:  Science       Date:  1985-02-01       Impact factor: 47.728

5.  Nucleotide sequence of the AIDS virus, LAV.

Authors:  S Wain-Hobson; P Sonigo; O Danos; S Cole; M Alizon
Journal:  Cell       Date:  1985-01       Impact factor: 41.582

6.  Non-cytocidal natural variants of human immunodeficiency virus isolated from AIDS patients with neurological disorders.

Authors:  R Anand; F Siegal; C Reed; T Cheung; S Forlenza; J Moore
Journal:  Lancet       Date:  1987-08-01       Impact factor: 79.321

7.  Neutralizing antibodies in HIV (HTLV-III) infection: correlation with clinical outcome and antibody response against different viral proteins.

Authors:  A Ranki; S H Weiss; S L Valle; J Antonen; K J Krohn
Journal:  Clin Exp Immunol       Date:  1987-08       Impact factor: 4.330

8.  Downregulation of cell surface molecules during noncytopathic infection of T cells with human immunodeficiency virus.

Authors:  M Stevenson; X H Zhang; D J Volsky
Journal:  J Virol       Date:  1987-12       Impact factor: 5.103

9.  Transmission and genetic shift of human immunodeficiency virus (HIV) in vivo.

Authors:  H Yoshiyama; N Kobayashi; T Matsui; H Nakashima; T Kajii; K Yamato; S Kotani; I Miyoshi; N Yamamoto
Journal:  Mol Biol Med       Date:  1987-12

10.  Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS.

Authors:  J A Levy; A D Hoffman; S M Kramer; J A Landis; J M Shimabukuro; L S Oshiro
Journal:  Science       Date:  1984-08-24       Impact factor: 47.728
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  1 in total

1.  Generation of hybrid human immunodeficiency virus utilizing the cotransfection method and analysis of cellular tropism.

Authors:  A Velpandi; T Nagashunmugam; S Murthy; M Cartas; C Monken; A Srinivasan
Journal:  J Virol       Date:  1991-09       Impact factor: 5.103
  1 in total

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