Literature DB >> 3501821

Transmission and genetic shift of human immunodeficiency virus (HIV) in vivo.

H Yoshiyama1, N Kobayashi, T Matsui, H Nakashima, T Kajii, K Yamato, S Kotani, I Miyoshi, N Yamamoto.   

Abstract

HIVYU-6 and HIVYU-7 were isolated from an acquired immune deficiency syndrome patient (MK) and his asymptomatic sexual partner (MM), respectively. YU-6 readily infected not only peripheral lymphocytes from normal individuals but also human T-cell lines such as H9, HUT-78, MOLT-4 and MT-4; YU-7, on the other hand, could not infect H9 and MT-4 cells. Furthermore, although autologous serum failed to neutralize YU-6, it was neutralized by the heterologous serum from the partner. Restriction endonuclease analysis of YU-6 demonstrated that it was a mixture of viruses. We have isolated two clones from YU-6 (YU-6-a and YU-6-b) by a plaque assay method and showed that YU-6-a had one more KpnI site than YU-6-b. It was also evident that YU-7 derived from YU-6-a, but had already shifted genetically from YU-6-a. Transmission of human immunodeficiency virus through heterosexual contact and a possible genetic shift of YU-6-a, b and YU-7 from a common progenitor virus in vivo is discussed.

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Year:  1987        PMID： 3501821

Source DB:  PubMed          Journal:  Mol Biol Med        ISSN： 0735-1313


  9 in total

1.  A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity.

Authors:  Kozi Ichiyama; Sei Yokoyama-Kumakura; Yuetsu Tanaka; Reiko Tanaka; Kunitaka Hirose; Kenji Bannai; Takeo Edamatsu; Mikiro Yanaka; Yoshiaki Niitani; Naoko Miyano-Kurosaki; Hiroshi Takaku; Yoshio Koyanagi; Naoki Yamamoto
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-17       Impact factor: 11.205

2.  Does viral tropism play a role in heterosexual transmission of HIV? Findings in the SIV-rhesus macaque model.

Authors:  C J Miller
Journal:  AIDS Res Hum Retroviruses       Date:  1998-04       Impact factor: 2.205

3.  Arrestin 3 mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21.

Authors:  Melissa A Byers; Psachal A Calloway; Laurie Shannon; Heather D Cunningham; Sarah Smith; Fang Li; Brian C Fassold; Charlotte M Vines
Journal:  J Immunol       Date:  2008-10-01       Impact factor: 5.422

4.  Characterization of human T-cell lines harboring defective human immunodeficiency virus type 1.

Authors:  Y Hamamoto; K Takamatsu; S Kobayashi; K Yamaguchi; N Yamamoto; N Kobayashi
Journal:  Virus Genes       Date:  1989-11       Impact factor: 2.332

5.  Heterogeneity of the ARV-2 strain and natural isolates of the human immunodeficiency virus.

Authors:  A F Etkin; M I Bukrinsky
Journal:  Arch Virol       Date:  1989       Impact factor: 2.574

6.  Cytocidal effect of tumor necrosis factor on cells chronically infected with human immunodeficiency virus (HIV): enhancement of HIV replication.

Authors:  T Matsuyama; Y Hamamoto; G Soma; D Mizuno; N Yamamoto; N Kobayashi
Journal:  J Virol       Date:  1989-06       Impact factor: 5.103

7.  Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus-infected cells without augmenting viral replication.

Authors:  N Kobayashi; Y Hamamoto; N Yamamoto; A Ishii; M Yonehara; S Yonehara
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

8.  In vivo replication capacity rather than in vitro macrophage tropism predicts efficiency of vaginal transmission of simian immunodeficiency virus or simian/human immunodeficiency virus in rhesus macaques.

Authors:  C J Miller; M Marthas; J Greenier; D Lu; P J Dailey; Y Lu
Journal:  J Virol       Date:  1998-04       Impact factor: 5.103

9.  Epigenetic mechanisms of drug resistance: drug-induced DNA hypermethylation and drug resistance.

Authors:  J Nyce; S Leonard; D Canupp; S Schulz; S Wong
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205
  9 in total

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