Literature DB >> 26041295

Mapping of a Region of the PA-X Protein of Influenza A Virus That Is Important for Its Shutoff Activity.

Kohei Oishi1, Seiya Yamayoshi2, Yoshihiro Kawaoka3.   

Abstract

Influenza A virus PA-X comprises an N-terminal PA endonuclease domain and a C-terminal PA-X-specific domain. PA-X reduces host and viral mRNA accumulation via its endonuclease function. Here, we found that the N-terminal 15 amino acids, particularly six basic amino acids, in the C-terminal PA-X-specific region are important for PA-X shutoff activity. These six basic amino acids enabled a PA deletion mutant to suppress protein expression at a level comparable to that of wild-type PA-X.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26041295      PMCID： PMC4524237          DOI： 10.1128/JVI.01132-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  14 in total

1.  PA-X decreases the pathogenicity of highly pathogenic H5N1 influenza A virus in avian species by inhibiting virus replication and host response.

Authors:  Jiao Hu; Yiqun Mo; Xiaoquan Wang; Min Gu; Zenglei Hu; Lei Zhong; Qiwen Wu; Xiaoli Hao; Shunlin Hu; Wenbo Liu; Huimou Liu; Xiaowen Liu; Xiufan Liu
Journal:  J Virol       Date:  2015-01-28       Impact factor: 5.103

2.  Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune Responses.

Authors:  Tsuyoshi Hayashi; Leslie A MacDonald; Toru Takimoto
Journal:  J Virol       Date:  2015-04-08       Impact factor: 5.103

3.  Identification of the N-terminal domain of the influenza virus PA responsible for the suppression of host protein synthesis.

Authors:  Emily A Desmet; Kendra A Bussey; Raychel Stone; Toru Takimoto
Journal:  J Virol       Date:  2013-01-02       Impact factor: 5.103

4.  The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit.

Authors:  Alexandre Dias; Denis Bouvier; Thibaut Crépin; Andrew A McCarthy; Darren J Hart; Florence Baudin; Stephen Cusack; Rob W H Ruigrok
Journal:  Nature       Date:  2009-02-04       Impact factor: 49.962

5.  Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site.

Authors:  Puwei Yuan; Mark Bartlam; Zhiyong Lou; Shoudeng Chen; Jie Zhou; Xiaojing He; Zongyang Lv; Ruowen Ge; Xuemei Li; Tao Deng; Ervin Fodor; Zihe Rao; Yingfang Liu
Journal:  Nature       Date:  2009-02-04       Impact factor: 49.962

6.  Twenty amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicity.

Authors:  Huijie Gao; Honglei Sun; Jiao Hu; Lu Qi; Jinliang Wang; Xin Xiong; Yu Wang; Qiming He; Yang Lin; Weili Kong; Lai-Giea Seng; Juan Pu; Kin-Chow Chang; Xiufan Liu; Jinhua Liu; Yipeng Sun
Journal:  J Gen Virol       Date:  2015-04-15       Impact factor: 3.891

7.  An overlapping protein-coding region in influenza A virus segment 3 modulates the host response.

Authors:  B W Jagger; H M Wise; J C Kash; K-A Walters; N M Wills; Y-L Xiao; R L Dunfee; L M Schwartzman; A Ozinsky; G L Bell; R M Dalton; A Lo; S Efstathiou; J F Atkins; A E Firth; J K Taubenberger; P Digard
Journal:  Science       Date:  2012-06-28       Impact factor: 47.728

8.  Ribosomal frameshifting used in influenza A virus expression occurs within the sequence UCC_UUU_CGU and is in the +1 direction.

Authors:  A E Firth; B W Jagger; H M Wise; C C Nelson; K Parsawar; N M Wills; S Napthine; J K Taubenberger; P Digard; J F Atkins
Journal:  Open Biol       Date:  2012-10       Impact factor: 6.411

9.  Influenza a virus host shutoff disables antiviral stress-induced translation arrest.

Authors:  Denys A Khaperskyy; Mohamed M Emara; Benjamin P Johnston; Paul Anderson; Todd F Hatchette; Craig McCormick
Journal:  PLoS Pathog       Date:  2014-07-10       Impact factor: 6.823

10.  Evolutionary conservation of the PA-X open reading frame in segment 3 of influenza A virus.

Authors:  Mang Shi; Brett W Jagger; Helen M Wise; Paul Digard; Edward C Holmes; Jeffery K Taubenberger
Journal:  J Virol       Date:  2012-09-05       Impact factor: 5.103
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  35 in total

1.  Interplay of PA-X and NS1 Proteins in Replication and Pathogenesis of a Temperature-Sensitive 2009 Pandemic H1N1 Influenza A Virus.

Authors:  Aitor Nogales; Laura Rodriguez; Marta L DeDiego; David J Topham; Luis Martínez-Sobrido
Journal:  J Virol       Date:  2017-08-10       Impact factor: 5.103

2.  Impacts of different expressions of PA-X protein on 2009 pandemic H1N1 virus replication, pathogenicity and host immune responses.

Authors:  Jinhwa Lee; Hai Yu; Yonghai Li; Jingjiao Ma; Yuekun Lang; Michael Duff; Jamie Henningson; Qinfang Liu; Yuhao Li; Abdou Nagy; Bhupinder Bawa; Zejun Li; Guangzhi Tong; Juergen A Richt; Wenjun Ma
Journal:  Virology       Date:  2017-01-29       Impact factor: 3.616

3.  An R195K Mutation in the PA-X Protein Increases the Virulence and Transmission of Influenza A Virus in Mammalian Hosts.

Authors:  Yipeng Sun; Zhe Hu; Xuxiao Zhang; Mingyue Chen; Zhen Wang; Guanlong Xu; Yuhai Bi; Qi Tong; Mingyang Wang; Honglei Sun; Juan Pu; Munir Iqbal; Jinhua Liu
Journal:  J Virol       Date:  2020-05-18       Impact factor: 5.103

4.  Residues in the PB2 and PA genes contribute to the pathogenicity of avian H7N3 influenza A virus in DBA/2 mice.

Authors:  Brittany L DesRochers; Rita E Chen; Anshu P Gounder; Amelia K Pinto; Traci Bricker; Camille N Linton; Corianne D Rogers; Graham D Williams; Richard J Webby; Adrianus C M Boon
Journal:  Virology       Date:  2016-04-20       Impact factor: 3.616

Review 5.  Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.

Authors:  John F Atkins; Gary Loughran; Pramod R Bhatt; Andrew E Firth; Pavel V Baranov
Journal:  Nucleic Acids Res       Date:  2016-07-19       Impact factor: 16.971

6.  Functional Evolution of the 2009 Pandemic H1N1 Influenza Virus NS1 and PA in Humans.

Authors:  Aitor Nogales; Marta L DeDiego; Luis Martinez-Sobrido; Kevin Chiem; David J Topham
Journal:  J Virol       Date:  2018-09-12       Impact factor: 5.103

7.  The influenza A virus host shutoff factor PA-X is rapidly turned over in a strain-specific manner.

Authors:  Rachel Emily Levene; Shailab D Shrestha; Marta Maria Gaglia
Journal:  J Virol       Date:  2021-01-27       Impact factor: 5.103

8.  The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA.

Authors:  Laura Bavagnoli; Stefano Cucuzza; Giulia Campanini; Francesca Rovida; Stefania Paolucci; Fausto Baldanti; Giovanni Maga
Journal:  Nucleic Acids Res       Date:  2015-09-17       Impact factor: 16.971

9.  Critical Role of the PA-X C-Terminal Domain of Influenza A Virus in Its Subcellular Localization and Shutoff Activity.

Authors:  Tsuyoshi Hayashi; Chutikarn Chaimayo; James McGuinness; Toru Takimoto
Journal:  J Virol       Date:  2016-07-27       Impact factor: 5.103

10.  N-Terminal Acetylation by NatB Is Required for the Shutoff Activity of Influenza A Virus PA-X.

Authors:  Kohei Oishi; Seiya Yamayoshi; Hiroko Kozuka-Hata; Masaaki Oyama; Yoshihiro Kawaoka
Journal:  Cell Rep       Date:  2018-07-24       Impact factor: 9.423
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