Literature DB >> 26033725

Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays.

Roland A Cooper1, Melissa D Conrad2, Quentin D Watson3, Stephanie J Huezo4, Harriet Ninsiima5, Patrick Tumwebaze5, Samuel L Nsobya5, Philip J Rosenthal2.   

Abstract

We evaluated markers of artemisinin resistance in Plasmodium falciparum isolated in Kampala in 2014. By standard in vitro assays, all isolates were highly sensitive to dihydroartemisinin (DHA). By the ring-stage survival assay, after a 6-h DHA pulse, parasitemia was undetectable in 40 of 43 cultures at 72 h. Two of 53 isolates had nonsynonymous K13-propeller gene polymorphisms but did not have the mutations associated with resistance in Asia. Thus, we did not see evidence for artemisinin resistance in Uganda.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 26033725      PMCID： PMC4505276          DOI： 10.1128/AAC.00921-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

1.  A molecular marker of artemisinin-resistant Plasmodium falciparum malaria.

Authors:  Frédéric Ariey; Benoit Witkowski; Chanaki Amaratunga; Johann Beghain; Anne-Claire Langlois; Nimol Khim; Saorin Kim; Valentine Duru; Christiane Bouchier; Laurence Ma; Pharath Lim; Rithea Leang; Socheat Duong; Sokunthea Sreng; Seila Suon; Char Meng Chuor; Denis Mey Bout; Sandie Ménard; William O Rogers; Blaise Genton; Thierry Fandeur; Olivo Miotto; Pascal Ringwald; Jacques Le Bras; Antoine Berry; Jean-Christophe Barale; Rick M Fairhurst; Françoise Benoit-Vical; Odile Mercereau-Puijalon; Didier Ménard
Journal:  Nature       Date:  2013-12-18       Impact factor: 49.962

2.  Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan children.

Authors:  Melissa D Conrad; Norbert LeClair; Emmanuel Arinaitwe; Humphrey Wanzira; Abel Kakuru; Victor Bigira; Mary Muhindo; Moses R Kamya; Jordan W Tappero; Bryan Greenhouse; Grant Dorsey; Philip J Rosenthal
Journal:  J Infect Dis       Date:  2014-03-08       Impact factor: 5.226

3.  Temporal changes in prevalence of molecular markers mediating antimalarial drug resistance in a high malaria transmission setting in Uganda.

Authors:  George W Mbogo; Sheila Nankoberanyi; Stephen Tukwasibwe; Frederick N Baliraine; Samuel L Nsobya; Melissa D Conrad; Emmanuel Arinaitwe; Moses Kamya; Jordan Tappero; Sarah G Staedke; Grant Dorsey; Bryan Greenhouse; Philip J Rosenthal
Journal:  Am J Trop Med Hyg       Date:  2014-05-05       Impact factor: 2.345

4.  A Single Mutation in K13 Predominates in Southern China and Is Associated With Delayed Clearance of Plasmodium falciparum Following Artemisinin Treatment.

Authors:  Fang Huang; Shannon Takala-Harrison; Christopher G Jacob; Hui Liu; Xiaodong Sun; Henglin Yang; Myaing M Nyunt; Matthew Adams; Shuisen Zhou; Zhigui Xia; Pascal Ringwald; Maria Dorina Bustos; Linhua Tang; Christopher V Plowe
Journal:  J Infect Dis       Date:  2015-04-24       Impact factor: 5.226

5.  Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children.

Authors:  Patrick Tumwebaze; Melissa D Conrad; Andrew Walakira; Norbert LeClair; Oswald Byaruhanga; Christine Nakazibwe; Benjamin Kozak; Jessica Bloome; Jaffer Okiring; Abel Kakuru; Victor Bigira; James Kapisi; Jennifer Legac; Jiri Gut; Roland A Cooper; Moses R Kamya; Diane V Havlir; Grant Dorsey; Bryan Greenhouse; Samuel L Nsobya; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2015-03-09       Impact factor: 5.191

6.  Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa.

Authors:  C V Plowe; A Djimde; M Bouare; O Doumbo; T E Wellems
Journal:  Am J Trop Med Hyg       Date:  1995-06       Impact factor: 2.345

7.  Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system.

Authors:  Mehdi Ghorbal; Molly Gorman; Cameron Ross Macpherson; Rafael Miyazawa Martins; Artur Scherf; Jose-Juan Lopez-Rubio
Journal:  Nat Biotechnol       Date:  2014-06-01       Impact factor: 54.908

8.  Spread of artemisinin resistance in Plasmodium falciparum malaria.

Authors:  Elizabeth A Ashley; Mehul Dhorda; Rick M Fairhurst; Chanaki Amaratunga; Parath Lim; Seila Suon; Sokunthea Sreng; Jennifer M Anderson; Sivanna Mao; Baramey Sam; Chantha Sopha; Char Meng Chuor; Chea Nguon; Siv Sovannaroth; Sasithon Pukrittayakamee; Podjanee Jittamala; Kesinee Chotivanich; Kitipumi Chutasmit; Chaiyaporn Suchatsoonthorn; Ratchadaporn Runcharoen; Tran Tinh Hien; Nguyen Thanh Thuy-Nhien; Ngo Viet Thanh; Nguyen Hoan Phu; Ye Htut; Kay-Thwe Han; Kyin Hla Aye; Olugbenga A Mokuolu; Rasaq R Olaosebikan; Olaleke O Folaranmi; Mayfong Mayxay; Maniphone Khanthavong; Bouasy Hongvanthong; Paul N Newton; Marie A Onyamboko; Caterina I Fanello; Antoinette K Tshefu; Neelima Mishra; Neena Valecha; Aung Pyae Phyo; Francois Nosten; Poravuth Yi; Rupam Tripura; Steffen Borrmann; Mahfudh Bashraheil; Judy Peshu; M Abul Faiz; Aniruddha Ghose; M Amir Hossain; Rasheda Samad; M Ridwanur Rahman; M Mahtabuddin Hasan; Akhterul Islam; Olivo Miotto; Roberto Amato; Bronwyn MacInnis; Jim Stalker; Dominic P Kwiatkowski; Zbynek Bozdech; Atthanee Jeeyapant; Phaik Yeong Cheah; Tharisara Sakulthaew; Jeremy Chalk; Benjamas Intharabut; Kamolrat Silamut; Sue J Lee; Benchawan Vihokhern; Chanon Kunasol; Mallika Imwong; Joel Tarning; Walter J Taylor; Shunmay Yeung; Charles J Woodrow; Jennifer A Flegg; Debashish Das; Jeffery Smith; Meera Venkatesan; Christopher V Plowe; Kasia Stepniewska; Philippe J Guerin; Arjen M Dondorp; Nicholas P Day; Nicholas J White
Journal:  N Engl J Med       Date:  2014-07-31       Impact factor: 91.245

9.  K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa.

Authors:  Edwin Kamau; Susana Campino; Lucas Amenga-Etego; Eleanor Drury; Deus Ishengoma; Kimberly Johnson; Dieudonne Mumba; Mihir Kekre; William Yavo; Daniel Mead; Marielle Bouyou-Akotet; Tobias Apinjoh; Lemu Golassa; Milijaona Randrianarivelojosia; Ben Andagalu; Oumou Maiga-Ascofare; Alfred Amambua-Ngwa; Paulina Tindana; Anita Ghansah; Bronwyn MacInnis; Dominic Kwiatkowski; Abdoulaye A Djimde
Journal:  J Infect Dis       Date:  2014-11-02       Impact factor: 5.226

10.  Early parasite clearance following artemisinin-based combination therapy among Ugandan children with uncomplicated Plasmodium falciparum malaria.

Authors:  Mary K Muhindo; Abel Kakuru; Prasanna Jagannathan; Ambrose Talisuna; Emmanuel Osilo; Francis Orukan; Emmanuel Arinaitwe; Jordan W Tappero; Frank Kaharuza; Moses R Kamya; Grant Dorsey
Journal:  Malar J       Date:  2014-01-28       Impact factor: 2.979
View more
  36 in total

1.  Alternative pathway to reduced artemisinin susceptibility in Plasmodium falciparum.

Authors:  Ryan C Henrici; Colin J Sutherland
Journal:  Proc Natl Acad Sci U S A       Date:  2018-11-28       Impact factor: 11.205

Review 2.  Plasmodium falciparum Resistance to Artemisinin Derivatives and Piperaquine: A Major Challenge for Malaria Elimination in Cambodia.

Authors:  Valentine Duru; Benoit Witkowski; Didier Ménard
Journal:  Am J Trop Med Hyg       Date:  2016-10-17       Impact factor: 2.345

3.  Surveillance of Genetic Variations Associated with Antimalarial Resistance of Plasmodium falciparum Isolates from Returned Migrant Workers in Wuhan, Central China.

Authors:  Yi Yao; Kai Wu; Mingxing Xu; Yan Yang; Yijing Zhang; Wenjing Yang; Ronghua Shang; Weixing Du; Huabing Tan; Jiangtao Chen; Min Lin; Jian Li
Journal:  Antimicrob Agents Chemother       Date:  2018-08-27       Impact factor: 5.191

4.  Comparative Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Malaria in Ugandan Children.

Authors:  Adoke Yeka; Erika Wallender; Ronald Mulebeke; Afizi Kibuuka; Ruth Kigozi; Agaba Bosco; Paul Kyambadde; Jimmy Opigo; Simeon Kalyesubula; Joseph Senzoga; Joanna Vinden; Melissa Conrad; Philip J Rosenthal
Journal:  J Infect Dis       Date:  2019-03-15       Impact factor: 5.226

Review 5.  Antimalarial Drug Resistance: A Threat to Malaria Elimination.

Authors:  Didier Menard; Arjen Dondorp
Journal:  Cold Spring Harb Perspect Med       Date:  2017-07-05       Impact factor: 6.915

6.  Polymorphisms in Plasmodium falciparum Kelch 13 and P. vivax Kelch 12 Genes in Parasites Collected from Three South Pacific Countries Prior to Extensive Exposure to Artemisinin Combination Therapies.

Authors:  Karryn Gresty; Karen Anderson; Cielo Pasay; Norman C Waters; Qin Cheng
Journal:  Antimicrob Agents Chemother       Date:  2019-06-24       Impact factor: 5.191

7.  The Diversity of the Plasmodium falciparum K13 Propeller Domain Did Not Increase after Implementation of Artemisinin-Based Combination Therapy in Uganda.

Authors:  Melissa D Conrad; Sam L Nsobya; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2019-09-23       Impact factor: 5.191

8.  Changing Antimalarial Drug Sensitivities in Uganda.

Authors:  Stephanie A Rasmussen; Frida G Ceja; Melissa D Conrad; Patrick K Tumwebaze; Oswald Byaruhanga; Thomas Katairo; Samuel L Nsobya; Philip J Rosenthal; Roland A Cooper
Journal:  Antimicrob Agents Chemother       Date:  2017-11-22       Impact factor: 5.191

Review 9.  Artemisinin-Resistant Plasmodium falciparum Malaria.

Authors:  Rick M Fairhurst; Arjen M Dondorp
Journal:  Microbiol Spectr       Date:  2016-06

10.  A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.

Authors:  Didier Ménard; Nimol Khim; Johann Beghain; Ayola A Adegnika; Mohammad Shafiul-Alam; Olukemi Amodu; Ghulam Rahim-Awab; Céline Barnadas; Antoine Berry; Yap Boum; Maria D Bustos; Jun Cao; Jun-Hu Chen; Louis Collet; Liwang Cui; Garib-Das Thakur; Alioune Dieye; Djibrine Djallé; Monique A Dorkenoo; Carole E Eboumbou-Moukoko; Fe-Esperanza-Caridad J Espino; Thierry Fandeur; Maria-Fatima Ferreira-da-Cruz; Abebe A Fola; Hans-Peter Fuehrer; Abdillahi M Hassan; Socrates Herrera; Bouasy Hongvanthong; Sandrine Houzé; Maman L Ibrahim; Mohammad Jahirul-Karim; Lubin Jiang; Shigeyuki Kano; Wasif Ali-Khan; Maniphone Khanthavong; Peter G Kremsner; Marcus Lacerda; Rithea Leang; Mindy Leelawong; Mei Li; Khin Lin; Jean-Baptiste Mazarati; Sandie Ménard; Isabelle Morlais; Hypolite Muhindo-Mavoko; Lise Musset; Kesara Na-Bangchang; Michael Nambozi; Karamoko Niaré; Harald Noedl; Jean-Bosco Ouédraogo; Dylan R Pillai; Bruno Pradines; Bui Quang-Phuc; Michael Ramharter; Milijaona Randrianarivelojosia; Jetsumon Sattabongkot; Abdiqani Sheikh-Omar; Kigbafori D Silué; Sodiomon B Sirima; Colin Sutherland; Din Syafruddin; Rachida Tahar; Lin-Hua Tang; Offianan A Touré; Patrick Tshibangu-wa-Tshibangu; Inès Vigan-Womas; Marian Warsame; Lyndes Wini; Sedigheh Zakeri; Saorin Kim; Rotha Eam; Laura Berne; Chanra Khean; Sophy Chy; Malen Ken; Kaknika Loch; Lydie Canier; Valentine Duru; Eric Legrand; Jean-Christophe Barale; Barbara Stokes; Judith Straimer; Benoit Witkowski; David A Fidock; Christophe Rogier; Pascal Ringwald; Frederic Ariey; Odile Mercereau-Puijalon
Journal:  N Engl J Med       Date:  2016-06-23       Impact factor: 91.245
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.