| Literature DB >> 25367300 |
Edwin Kamau1, Susana Campino2, Lucas Amenga-Etego3, Eleanor Drury2, Deus Ishengoma4, Kimberly Johnson5, Dieudonne Mumba6, Mihir Kekre2, William Yavo7, Daniel Mead2, Marielle Bouyou-Akotet8, Tobias Apinjoh9, Lemu Golassa10, Milijaona Randrianarivelojosia11, Ben Andagalu1, Oumou Maiga-Ascofare12, Alfred Amambua-Ngwa13, Paulina Tindana3, Anita Ghansah14, Bronwyn MacInnis2, Dominic Kwiatkowski15, Abdoulaye A Djimde16.
Abstract
Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance in Southeast Asia. This study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa. A total of 1212 P. falciparum samples collected from 12 countries were sequenced. None of the K13-propeller mutations previously reported in Southeast Asia were found, but 22 unique mutations were detected, of which 7 were nonsynonymous. Allele frequencies ranged between 1% and 3%. Three mutations were observed in >1 country, and the A578S was present in parasites from 5 countries. This study provides the baseline prevalence of K13-propeller mutations in sub-Saharan Africa.Entities:
Keywords: K13-propeller; artemisinin resistance; sub-Saharan Africa
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Year: 2014 PMID： 25367300 PMCID： PMC4827505 DOI： 10.1093/infdis/jiu608
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226