S A Abbasi1, W G Hundley2, D A Bluemke3, M Jerosch-Herold4, R Blankstein5, Steffen E Petersen6, Oliver J Rider7, J A C Lima8, M A Allison9, V L Murthy10, R V Shah11. 1. Department of Medicine (Cardiology Division), Warren Alpert Medical School of Brown University, United States. 2. Department of Internal Medicine/Cardiology, Wake Forest University Health Sciences, Winston-Salem, NC, United States. 3. National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, United States. 4. Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States. 5. Noninvasive Cardiovascular Imaging Program, Department of Medicine (Cardiovascular Division) and Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States. 6. William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK. 7. Department of Cardiovascular Medicine, University of Oxford, Oxford, UK. 8. Division of Cardiology, Heart and Vascular Institute, Johns Hopkins School of Medicine, Baltimore, MD, Unites Sates. 9. Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, United States. 10. Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Unites states; Division of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, MI, United States. Electronic address: vlmurthy@med.umich.edu. 11. Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, MA, United States. Electronic address: rshah1@bidmc.harvard.edu.
Abstract
BACKGROUND AND AIMS: Visceral fat (VF) is a source of pro-inflammatory adipokines implicated in cardiac remodeling. We sought to determine the impact of visceral fat and subcutaneous fat (SQ) depots on left ventricular (LV) structure, function, and geometry in the Multi-Ethnic Study of Atherosclerosis (MESA). METHODS AND RESULTS: We performed a post-hoc analysis on 1151 participants from MESA with cardiac magnetic resonance quantification of LV mass and LV mass-to-volume ratio (LVMV, an index of concentricity) and computed tomographic-derived SQ and VF area. Multivariable regression models to estimate association between height-indexed SQ and VF area (per cm(2)/m) with height-indexed LV mass (per height(2.7)) and LVMV were constructed, adjusted for clinical, biochemical, and demographic covariates. We found that both VF and SQ area were associated with height-indexed LV mass (ρ = 0.36 and 0.12, P < 0.0001, respectively), while only VF area was associated with LVMV (ρ = 0.28, P < 0.0001). Individuals with above-median VF had lower LV ejection fraction, greater indexed LV volumes and mass, and higher LVMV (all P < 0.001). In multivariable models adjusted for weight, VF (but not SQ) area was associated with LV concentricity and LV mass index, across both sexes. CONCLUSION: Visceral adiposity is independently associated with LV concentricity, a precursor to heart failure. Further study into the role of VF in LV remodeling as a potential therapeutic target is warranted.
BACKGROUND AND AIMS: Visceral fat (VF) is a source of pro-inflammatory adipokines implicated in cardiac remodeling. We sought to determine the impact of visceral fat and subcutaneous fat (SQ) depots on left ventricular (LV) structure, function, and geometry in the Multi-Ethnic Study of Atherosclerosis (MESA). METHODS AND RESULTS: We performed a post-hoc analysis on 1151 participants from MESA with cardiac magnetic resonance quantification of LV mass and LV mass-to-volume ratio (LVMV, an index of concentricity) and computed tomographic-derived SQ and VF area. Multivariable regression models to estimate association between height-indexed SQ and VF area (per cm(2)/m) with height-indexed LV mass (per height(2.7)) and LVMV were constructed, adjusted for clinical, biochemical, and demographic covariates. We found that both VF and SQ area were associated with height-indexed LV mass (ρ = 0.36 and 0.12, P < 0.0001, respectively), while only VF area was associated with LVMV (ρ = 0.28, P < 0.0001). Individuals with above-median VF had lower LV ejection fraction, greater indexed LV volumes and mass, and higher LVMV (all P < 0.001). In multivariable models adjusted for weight, VF (but not SQ) area was associated with LV concentricity and LV mass index, across both sexes. CONCLUSION: Visceral adiposity is independently associated with LV concentricity, a precursor to heart failure. Further study into the role of VF in LV remodeling as a potential therapeutic target is warranted.
Authors: Melissa G Farb; Sherman Bigornia; Melanie Mott; Kahraman Tanriverdi; Kristine M Morin; Jane E Freedman; Lija Joseph; Donald T Hess; Caroline M Apovian; Joseph A Vita; Noyan Gokce Journal: J Am Coll Cardiol Date: 2011-07-12 Impact factor: 24.094
Authors: Giovanni de Simone; Fabrizio Pasanisi; Aldo L Ferrara; Mary J Roman; Elisa T Lee; Franco Contaldo; Barbara V Howard; Richard B Devereux Journal: Int J Cardiol Date: 2012-10-09 Impact factor: 4.164
Authors: G de Simone; R B Devereux; T R Kimball; G F Mureddu; M J Roman; F Contaldo; S R Daniels Journal: Hypertension Date: 1998-05 Impact factor: 10.190
Authors: Raghava S Velagaleti; Philimon Gona; Michael L Chuang; Carol J Salton; Caroline S Fox; Susan J Blease; Susan B Yeon; Warren J Manning; Christopher J O'Donnell Journal: Circ Cardiovasc Imaging Date: 2010-03-05 Impact factor: 7.792
Authors: Eui-Young Choi; Hossein Bahrami; Colin O Wu; Philip Greenland; Mary Cushman; Lori B Daniels; Andre L C Almeida; Kihei Yoneyama; Anders Opdahl; Aditya Jain; Michael H Criqui; David Siscovick; Christine Darwin; Alan Maisel; David A Bluemke; Joao A C Lima Journal: Circ Heart Fail Date: 2012-10-02 Impact factor: 8.790
Authors: Boaz D Rosen; Thor Edvardsen; Shenghan Lai; Ernesto Castillo; Li Pan; Michael Jerosch-Herold; Shantanu Sinha; Richard Kronmal; Donna Arnett; John R Crouse; Susan R Heckbert; David A Bluemke; Joao A C Lima Journal: Circulation Date: 2005-08-16 Impact factor: 29.690
Authors: Khawaja Afzal Ammar; Margaret M Redfield; Douglas W Mahoney; Matthew Johnson; Steven J Jacobsen; Richard J Rodeheffer Journal: Am Heart J Date: 2008-11 Impact factor: 4.749
Authors: Walter Oliver; Gwendolyn Matthews; Colby R Ayers; Sonia Garg; Sachin Gupta; Ian J Neeland; Mark H Drazner; Jarett D Berry; Susan Matulevicius; James A de Lemos Journal: Circ Cardiovasc Imaging Date: 2017-02 Impact factor: 7.792
Authors: Ching-Ti Liu; Kerry E Broe; Yanhua Zhou; Steven K Boyd; L Adrienne Cupples; Marian T Hannan; Elise Lim; Robert R McLean; Elizabeth J Samelson; Mary L Bouxsein; Douglas P Kiel Journal: J Bone Miner Res Date: 2016-09-06 Impact factor: 6.741
Authors: Ravi V Shah; Amanda Anderson; Jingzhong Ding; Matthew Budoff; Oliver Rider; Steffen E Petersen; Majken Karoline Jensen; Manja Koch; Matthew Allison; Nadine Kawel-Boehm; Jessica Wisocky; Michael Jerosch-Herold; Kenneth Mukamal; João A C Lima; Venkatesh L Murthy Journal: JACC Cardiovasc Imaging Date: 2017-03-15
Authors: R V Shah; V L Murthy; M A Allison; J Ding; M Budoff; A C Frazier-Wood; J A C Lima; L Steffen; D Siscovick; K L Tucker; P Ouyang; S A Abbasi; K Danielson; M Jerosch-Herold; D Mozaffarian Journal: Nutr Metab Cardiovasc Dis Date: 2015-12-29 Impact factor: 4.222
Authors: Tetz C Lee; Zhezhen Jin; Shunichi Homma; Koki Nakanishi; Mitchell S V Elkind; Tatjana Rundek; Aylin Tugcu; Kenji Matsumoto; Ralph L Sacco; Marco R Di Tullio Journal: J Am Soc Echocardiogr Date: 2019-07-13 Impact factor: 5.251
Authors: Aferdita Spahillari; Sameera Talegawkar; Adolfo Correa; J Jeffrey Carr; James G Terry; João Lima; Jane E Freedman; Saumya Das; Robb Kociol; Sarah de Ferranti; Donya Mohebali; Stanford Mwasongwe; Katherine L Tucker; Venkatesh L Murthy; Ravi V Shah Journal: Circ Heart Fail Date: 2017-02 Impact factor: 8.790
Authors: Mary J Christoph; Matthew A Allison; James S Pankow; Paul A Decker; Phillip S Kirsch; Michael Y Tsai; Michele M Sale; Mariza de Andrade; Hugues Sicotte; Weihong Tang; Naomi Q Hanson; Cecilia Berardi; Christina L Wassel; Nicholas B Larson; Suzette J Bielinski Journal: Obesity (Silver Spring) Date: 2015-12-06 Impact factor: 5.002
Authors: Ravi V Shah; Ashish S Yeri; Venkatesh L Murthy; Joe M Massaro; Ralph D'Agostino; Jane E Freedman; Michelle T Long; Caroline S Fox; Saumya Das; Emelia J Benjamin; Ramachandran S Vasan; Christopher J O'Donnell; Udo Hoffmann Journal: JAMA Cardiol Date: 2017-11-01 Impact factor: 14.676
Authors: Kirti Magudia; Christopher P Bridge; Camden P Bay; Ana Babic; Florian J Fintelmann; Fabian M Troschel; Nityanand Miskin; William C Wrobel; Lauren K Brais; Katherine P Andriole; Brian M Wolpin; Michael H Rosenthal Journal: Radiology Date: 2020-11-24 Impact factor: 11.105