BACKGROUND: The impact of catheter ablation of ventricular tachycardia (VT) on all-cause mortality remains unknown. OBJECTIVE: The purpose of this study was to examine the association between VT recurrence after ablation and survival in patients with scar-related VT. METHODS: Analysis of 2061 patients with structural heart disease referred for catheter ablation of scar-related VT from 12 international centers was performed. Data on clinical and procedural variables, VT recurrence, and mortality were analyzed. Kaplan-Meier analysis was used to estimate freedom from recurrent VT, transplant, and death. Cox proportional hazards frailty models were used to analyze the effect of risk factors on VT recurrence and mortality. RESULTS: One-year freedom from VT recurrence was 70% (72% in ischemic and 68% in nonischemic cardiomyopathy). Fifty-seven patients (3%) underwent cardiac transplantation, and 216 (10%) died during follow-up. At 1 year, the estimated rate of transplant and/or mortality was 15% (same for ischemic and nonischemic cardiomyopathy). Transplant-free survival was significantly higher in patients without VT recurrence than in those with recurrence (90% vs 71%, P<.001). In multivariable analysis, recurrence of VT after ablation showed the highest risk for transplant and/or mortality [hazard ratio 6.9 (95% CI 5.3-9.0), P<.001]. In patients with ejection fraction <30% and across all New York Heart Association functional classes, improved transplant-free survival was seen in those without VT recurrence. CONCLUSION: Catheter ablation of VT in patients with structural heart disease results in 70% freedom from VT recurrence, with an overall transplant and/or mortality rate of 15% at 1 year. Freedom from VT recurrence is associated with improved transplant-free survival, independent of heart failure severity.
BACKGROUND: The impact of catheter ablation of ventricular tachycardia (VT) on all-cause mortality remains unknown. OBJECTIVE: The purpose of this study was to examine the association between VT recurrence after ablation and survival inpatients with scar-related VT. METHODS: Analysis of 2061 patients with structural heart disease referred for catheter ablation of scar-related VT from 12 international centers was performed. Data on clinical and procedural variables, VT recurrence, and mortality were analyzed. Kaplan-Meier analysis was used to estimate freedom from recurrent VT, transplant, and death. Cox proportional hazards frailty models were used to analyze the effect of risk factors on VT recurrence and mortality. RESULTS: One-year freedom from VT recurrence was 70% (72% in ischemic and 68% in nonischemic cardiomyopathy). Fifty-seven patients (3%) underwent cardiac transplantation, and 216 (10%) died during follow-up. At 1 year, the estimated rate of transplant and/or mortality was 15% (same for ischemic and nonischemic cardiomyopathy). Transplant-free survival was significantly higher in patients without VT recurrence than in those with recurrence (90% vs 71%, P<.001). In multivariable analysis, recurrence of VT after ablation showed the highest risk for transplant and/or mortality [hazard ratio 6.9 (95% CI 5.3-9.0), P<.001]. In patients with ejection fraction <30% and across all New York Heart Association functional classes, improved transplant-free survival was seen in those without VT recurrence. CONCLUSION: Catheter ablation of VT in patients with structural heart disease results in 70% freedom from VT recurrence, with an overall transplant and/or mortality rate of 15% at 1 year. Freedom from VT recurrence is associated with improved transplant-free survival, independent of heart failure severity.
Authors: Carine F van Huls van Taxis; Adrianus P Wijnmaalen; Sebastiaan R Piers; Rob J van der Geest; Martin J Schalij; Katja Zeppenfeld Journal: JACC Cardiovasc Imaging Date: 2013-01
Authors: Frédéric Sacher; Kurt Roberts-Thomson; Philippe Maury; Usha Tedrow; Isabelle Nault; Daniel Steven; Meleze Hocini; Bruce Koplan; Lionel Leroux; Nicolas Derval; Jens Seiler; Matthew J Wright; Laurence Epstein; Michel Haissaguerre; Pierre Jais; William G Stevenson Journal: J Am Coll Cardiol Date: 2010-05-25 Impact factor: 24.094
Authors: Luigi Di Biase; Pasquale Santangeli; David J Burkhardt; Rong Bai; Prasant Mohanty; Corrado Carbucicchio; Antonio Dello Russo; Michela Casella; Sanghamitra Mohanty; Agnes Pump; Richard Hongo; Salwa Beheiry; Gemma Pelargonio; Pietro Santarelli; Martina Zucchetti; Rodney Horton; Javier E Sanchez; Claude S Elayi; Dhanunjay Lakkireddy; Claudio Tondo; Andrea Natale Journal: J Am Coll Cardiol Date: 2012-07-10 Impact factor: 24.094
Authors: Hildegard Tanner; Gerhard Hindricks; Marius Volkmer; Steve Furniss; Volker Kühlkamp; Dominique Lacroix; Christian DE Chillou; Jesús Almendral; Domenico Caponi; Karl-Heinz Kuck; Hans Kottkamp Journal: J Cardiovasc Electrophysiol Date: 2009-07-28
Authors: Arthur J Moss; Claudio Schuger; Christopher A Beck; Mary W Brown; David S Cannom; James P Daubert; N A Mark Estes; Henry Greenberg; W Jackson Hall; David T Huang; Josef Kautzner; Helmut Klein; Scott McNitt; Brian Olshansky; Morio Shoda; David Wilber; Wojciech Zareba Journal: N Engl J Med Date: 2012-11-06 Impact factor: 91.245
Authors: Pierre Jaïs; Philippe Maury; Paul Khairy; Frédéric Sacher; Isabelle Nault; Yuki Komatsu; Mélèze Hocini; Andrei Forclaz; Amir S Jadidi; Rukshen Weerasooryia; Ashok Shah; Nicolas Derval; Hubert Cochet; Sebastien Knecht; Shinsuke Miyazaki; Nick Linton; Lena Rivard; Matthew Wright; Stephen B Wilton; Daniel Scherr; Patrizio Pascale; Laurent Roten; Michala Pederson; Pierre Bordachar; François Laurent; Steven J Kim; Philippe Ritter; Jacques Clementy; Michel Haïssaguerre Journal: Circulation Date: 2012-04-04 Impact factor: 29.690
Authors: Justin Hayase; Veronica Dusi; Duc Do; Olujimi A Ajijola; Marmar Vaseghi; Jay M Lee; Jane Yanagawa; Nir Hoftman; Sha'Shonda Revels; Eric F Buch; Houman Khakpour; Osamu Fujimura; Yuliya Krokhaleva; Carlos Macias; Julie Sorg; Jean Gima; Geraldine Pavez; Noel G Boyle; Kalyanam Shivkumar; Jason S Bradfield Journal: J Cardiovasc Electrophysiol Date: 2020-06-30
Authors: Edmond M Cronin; Frank M Bogun; Philippe Maury; Petr Peichl; Minglong Chen; Narayanan Namboodiri; Luis Aguinaga; Luiz Roberto Leite; Sana M Al-Khatib; Elad Anter; Antonio Berruezo; David J Callans; Mina K Chung; Phillip Cuculich; Andre d'Avila; Barbara J Deal; Paolo Della Bella; Thomas Deneke; Timm-Michael Dickfeld; Claudio Hadid; Haris M Haqqani; G Neal Kay; Rakesh Latchamsetty; Francis Marchlinski; John M Miller; Akihiko Nogami; Akash R Patel; Rajeev Kumar Pathak; Luis C Saenz Morales; Pasquale Santangeli; John L Sapp; Andrea Sarkozy; Kyoko Soejima; William G Stevenson; Usha B Tedrow; Wendy S Tzou; Niraj Varma; Katja Zeppenfeld Journal: J Interv Card Electrophysiol Date: 2020-10 Impact factor: 1.900
Authors: Sean D Pokorney; Daniel J Friedman; Hugh Calkins; David J Callans; Emile G Daoud; Paolo Della-Bella; Kevin P Jackson; Kalyanam Shivkumar; Samir Saba; John Sapp; William G Stevenson; Sana M Al-Khatib Journal: Heart Rhythm Date: 2016-04-02 Impact factor: 6.343
Authors: Pasquale Vergara; Wendy S Tzou; Roderick Tung; Chiara Brombin; Alessandro Nonis; Marmar Vaseghi; David S Frankel; Luigi Di Biase; Usha Tedrow; Nilesh Mathuria; Shiro Nakahara; Venkat Tholakanahalli; T Jared Bunch; J Peter Weiss; Timm Dickfeld; Dhanunjaya Lakireddy; J David Burkhardt; Pasquale Santangeli; David Callans; Andrea Natale; Francis Marchlinski; William G Stevenson; Kalyanam Shivkumar; William H Sauer; Paolo Della Bella Journal: Circ Arrhythm Electrophysiol Date: 2018-12