Literature DB >> 26024776

Advances in measuring single-cell pharmacology in vivo.

Claudio Vinegoni1, J Matthew Dubach2, Greg M Thurber3, Miles A Miller2, Ralph Mazitschek2, Ralph Weissleder2.   

Abstract

Measuring key pharmacokinetic and pharmacodynamic parameters in vivo at the single cell level is likely to enhance drug discovery and development. In this review, we summarize recent advances in this field and highlight current and future capabilities.
Copyright © 2015 Elsevier Ltd. All rights reserved.

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Year:  2015        PMID： 26024776      PMCID： PMC4567932          DOI： 10.1016/j.drudis.2015.05.011

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  29 in total

1.  A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery.

Authors:  P Poulin; F P Theil
Journal:  J Pharm Sci       Date:  2000-01       Impact factor: 3.534

Review 2.  Quantitative measurement of single cell dynamics.

Authors:  Denise Bakstad; Antony Adamson; David G Spiller; Michael R H White
Journal:  Curr Opin Biotechnol       Date:  2011-11-30       Impact factor: 9.740

3.  A cell-based molecular transport simulator for pharmacokinetic prediction and cheminformatic exploration.

Authors:  Xinyuan Zhang; Kerby Shedden; Gus R Rosania
Journal:  Mol Pharm       Date:  2006 Nov-Dec       Impact factor: 4.939

Review 4.  Microscopic imaging techniques for drug discovery.

Authors:  Andrew Bullen
Journal:  Nat Rev Drug Discov       Date:  2008-01       Impact factor: 84.694

5.  Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.

Authors:  Daniel Martinez Molina; Rozbeh Jafari; Marina Ignatushchenko; Takahiro Seki; E Andreas Larsson; Chen Dan; Lekshmy Sreekumar; Yihai Cao; Pär Nordlund
Journal:  Science       Date:  2013-07-05       Impact factor: 47.728

6.  Tracking cancer drugs in living cells by thermal profiling of the proteome.

Authors:  Mikhail M Savitski; Friedrich B M Reinhard; Holger Franken; Thilo Werner; Maria Fälth Savitski; Dirk Eberhard; Daniel Martinez Molina; Rozbeh Jafari; Rebecca Bakszt Dovega; Susan Klaeger; Bernhard Kuster; Pär Nordlund; Marcus Bantscheff; Gerard Drewes
Journal:  Science       Date:  2014-10-02       Impact factor: 47.728

7.  In vivo imaging of specific drug-target binding at subcellular resolution.

Authors:  J M Dubach; C Vinegoni; R Mazitschek; P Fumene Feruglio; L A Cameron; R Weissleder
Journal:  Nat Commun       Date:  2014-05-28       Impact factor: 14.919

Review 8.  Intravital imaging.

Authors:  Mikael J Pittet; Ralph Weissleder
Journal:  Cell       Date:  2011-11-23       Impact factor: 41.582

Review 9.  Influence of tumour micro-environment heterogeneity on therapeutic response.

Authors:  Melissa R Junttila; Frederic J de Sauvage
Journal:  Nature       Date:  2013-09-19       Impact factor: 49.962

10.  High-sensitivity measurements of multiple kinase activities in live single cells.

Authors:  Sergi Regot; Jacob J Hughey; Bryce T Bajar; Silvia Carrasco; Markus W Covert
Journal:  Cell       Date:  2014-06-19       Impact factor: 41.582
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  12 in total

1.  Microenvironmental Niches and Sanctuaries: A Route to Acquired Resistance.

Authors:  Judith Pérez-Velázquez; Jana L Gevertz; Aleksandra Karolak; Katarzyna A Rejniak
Journal:  Adv Exp Med Biol       Date:  2016       Impact factor: 2.622

2.  Micropharmacology: An In Silico Approach for Assessing Drug Efficacy Within a Tumor Tissue.

Authors:  Aleksandra Karolak; Katarzyna A Rejniak
Journal:  Bull Math Biol       Date:  2018-02-08       Impact factor: 1.758

Review 3.  Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior.

Authors:  Miles A Miller; Ralph Weissleder
Journal:  Adv Drug Deliv Rev       Date:  2016-06-04       Impact factor: 15.470

4.  Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging.

Authors:  Claudio Vinegoni; Paolo Fumene Feruglio; Christian Brand; Sungon Lee; Antoinette E Nibbs; Shawn Stapleton; Sunil Shah; Ignacy Gryczynski; Thomas Reiner; Ralph Mazitschek; Ralph Weissleder
Journal:  Nat Protoc       Date:  2017-06-29       Impact factor: 13.491

5.  Quantitative imaging of receptor-ligand engagement in intact live animals.

Authors:  Alena Rudkouskaya; Nattawut Sinsuebphon; Jamie Ward; Kate Tubbesing; Xavier Intes; Margarida Barroso
Journal:  J Control Release       Date:  2018-07-20       Impact factor: 9.776

Review 6.  Fluorescence anisotropy imaging in drug discovery.

Authors:  Claudio Vinegoni; Paolo Fumene Feruglio; Ignacy Gryczynski; Ralph Mazitschek; Ralph Weissleder
Journal:  Adv Drug Deliv Rev       Date:  2018-02-02       Impact factor: 15.470

Review 7.  Drug permeation and metabolism in Mycobacterium tuberculosis: Prioritising local exposure as essential criterion in new TB drug development.

Authors:  Lloyd Tanner; Paolo Denti; Lubbe Wiesner; Digby F Warner
Journal:  IUBMB Life       Date:  2018-06-22       Impact factor: 3.885

8.  Extended dynamic range imaging for noise mitigation in fluorescence anisotropy imaging.

Authors:  Paolo Feruglio; Claudio Vinegoni; Ralph Weissleder
Journal:  J Biomed Opt       Date:  2020-08       Impact factor: 3.170

9.  Fast Dynamic in vivo Monitoring of Erk Activity at Single Cell Resolution in DREKA Zebrafish.

Authors:  Vanessa Mayr; Caterina Sturtzel; Manuela Stadler; Sarah Grissenberger; Martin Distel
Journal:  Front Cell Dev Biol       Date:  2018-09-25

10.  Targeting Ligand Specificity Linked to Tumor Tissue Topological Heterogeneity via Single-Cell Micro-Pharmacological Modeling.

Authors:  Aleksandra Karolak; Veronica C Estrella; Amanda S Huynh; Tingan Chen; Josef Vagner; David L Morse; Katarzyna A Rejniak
Journal:  Sci Rep       Date:  2018-02-26       Impact factor: 4.379
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