Literature DB >> 26020497

Off-target mutations are rare in Cas9-modified mice.

Vivek Iyer1, Bin Shen2, Wensheng Zhang3, Alex Hodgkins1, Thomas Keane1, Xingxu Huang2, William C Skarnes1.   

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Year:  2015        PMID： 26020497     DOI： 10.1038/nmeth.3408

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


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  6 in total

1.  Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity.

Authors:  F Ann Ran; Patrick D Hsu; Chie-Yu Lin; Jonathan S Gootenberg; Silvana Konermann; Alexandro E Trevino; David A Scott; Azusa Inoue; Shogo Matoba; Yi Zhang; Feng Zhang
Journal:  Cell       Date:  2013-08-29       Impact factor: 41.582

2.  Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects.

Authors:  Bin Shen; Wensheng Zhang; Jun Zhang; Jiankui Zhou; Jianying Wang; Li Chen; Lu Wang; Alex Hodgkins; Vivek Iyer; Xingxu Huang; William C Skarnes
Journal:  Nat Methods       Date:  2014-03-02       Impact factor: 28.547

3.  Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs.

Authors:  Cory Smith; Athurva Gore; Wei Yan; Leire Abalde-Atristain; Zhe Li; Chaoxia He; Ying Wang; Robert A Brodsky; Kun Zhang; Linzhao Cheng; Zhaohui Ye
Journal:  Cell Stem Cell       Date:  2014-07-03       Impact factor: 24.633

4.  Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones.

Authors:  Keiichiro Suzuki; Chang Yu; Jing Qu; Mo Li; Xiaotian Yao; Tingting Yuan; April Goebl; Senwei Tang; Ruotong Ren; Emi Aizawa; Fan Zhang; Xiuling Xu; Rupa Devi Soligalla; Feng Chen; Jessica Kim; Na Young Kim; Hsin-Kai Liao; Chris Benner; Concepcion Rodriguez Esteban; Yabin Jin; Guang-Hui Liu; Yingrui Li; Juan Carlos Izpisua Belmonte
Journal:  Cell Stem Cell       Date:  2014-07-03       Impact factor: 24.633

5.  Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing.

Authors:  Adrian Veres; Bridget S Gosis; Qiurong Ding; Ryan Collins; Ashok Ragavendran; Harrison Brand; Serkan Erdin; Chad A Cowan; Michael E Talkowski; Kiran Musunuru
Journal:  Cell Stem Cell       Date:  2014-07-03       Impact factor: 24.633

6.  One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering.

Authors:  Haoyi Wang; Hui Yang; Chikdu S Shivalila; Meelad M Dawlaty; Albert W Cheng; Feng Zhang; Rudolf Jaenisch
Journal:  Cell       Date:  2013-05-02       Impact factor: 41.582
  6 in total
  99 in total

Review 1.  Creating and evaluating accurate CRISPR-Cas9 scalpels for genomic surgery.

Authors:  Mehmet Fatih Bolukbasi; Ankit Gupta; Scot A Wolfe
Journal:  Nat Methods       Date:  2016-01       Impact factor: 28.547

Review 2.  Salient Features of Endonuclease Platforms for Therapeutic Genome Editing.

Authors:  Michael T Certo; Richard A Morgan
Journal:  Mol Ther       Date:  2016-01-22       Impact factor: 11.454

Review 3.  Gene-edited CRISPy Critters for alcohol research.

Authors:  Gregg E Homanics
Journal:  Alcohol       Date:  2018-03-07       Impact factor: 2.405

Review 4.  Post-modern therapeutic approaches for progressive myoclonus epilepsy.

Authors:  Berge A Minassian
Journal:  Epileptic Disord       Date:  2016-09-01       Impact factor: 1.819

5.  Breaking-Cas-interactive design of guide RNAs for CRISPR-Cas experiments for ENSEMBL genomes.

Authors:  Juan C Oliveros; Mònica Franch; Daniel Tabas-Madrid; David San-León; Lluis Montoliu; Pilar Cubas; Florencio Pazos
Journal:  Nucleic Acids Res       Date:  2016-05-10       Impact factor: 16.971

6.  No off-target mutations in functional genome regions of a CRISPR/Cas9-generated monkey model of muscular dystrophy.

Authors:  Shuang Wang; Shuaiwei Ren; Raoxian Bai; Puhao Xiao; Qin Zhou; Yin Zhou; Zhigang Zhou; Yuyu Niu; Weizhi Ji; Yongchang Chen
Journal:  J Biol Chem       Date:  2018-06-25       Impact factor: 5.157

7.  Increasing the efficiency of CRISPR/Cas9-mediated precise genome editing in rats by inhibiting NHEJ and using Cas9 protein.

Authors:  Yuanwu Ma; Wei Chen; Xu Zhang; Lei Yu; Wei Dong; Shuo Pan; Shan Gao; Xingxu Huang; Lianfeng Zhang
Journal:  RNA Biol       Date:  2016-05-10       Impact factor: 4.652

8.  CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington's disease.

Authors:  Su Yang; Renbao Chang; Huiming Yang; Ting Zhao; Yan Hong; Ha Eun Kong; Xiaobo Sun; Zhaohui Qin; Peng Jin; Shihua Li; Xiao-Jiang Li
Journal:  J Clin Invest       Date:  2017-06-19       Impact factor: 14.808

Review 9.  Sharing mutations: are biobanks still required in the post-CRISPR/Cas9 era?

Authors:  Janet Kenyon; Martin D Fray
Journal:  Mamm Genome       Date:  2017-07-18       Impact factor: 2.957

Review 10.  Polygenic Causes of Congenital Diaphragmatic Hernia Produce Common Lung Pathologies.

Authors:  Patricia K Donahoe; Mauro Longoni; Frances A High
Journal:  Am J Pathol       Date:  2016-08-24       Impact factor: 4.307
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