S Jafari1, S-G Ashrafizadeh1, A Zeinoddini2, M Rasoulinejad1, P Entezari2, S Seddighi3, S Akhondzadeh2. 1. Department of Infectious Diseases, Imam Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2. Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. 3. Imam Hospital, Ilam University of Medical Sciences, Ilam, Iran.
Abstract
WHAT IS KNOWN AND OBJECTIVE: Depression is a debilitating complication of brucellosis and how best to treat this is a matter of debate. Inflammatory processes are involved in the pathogenesis of both brucellosis and depression. Therefore, we hypothesized that celecoxib could be beneficial for the treatment of depression due to brucellosis. METHODS:Forty outpatients with depression due to brucellosis with a Hamilton Depression Rating Scale score (HDRS) <19 participated in a randomized, double-blind, placebo-controlled trial and underwent 8 weeks of treatment with either celecoxib (200 mg bid) or placebo as an adjunctive to antibiotic therapy. Patients were evaluated using HDRS at baseline and weeks 4 and 8. RESULT AND DISCUSSION: Repeated-measures analysis demonstrated significant effect for time × treatment interaction on the HDRS score [F (1·43, 57·41) = 37·22, P < 0·001]. Significantly greater response to treatment occurred in the celecoxib group than in the placebo group at the study end [10 patients (50%) vs. no patient (0%), respectively, P < 0·001]. No serious adverse event was observed. WHAT IS NEW AND CONCLUSION:Celecoxib is a safe and effective treatment for depression due to brucellosis when compared with placebo.
RCT Entities:
WHAT IS KNOWN AND OBJECTIVE:Depression is a debilitating complication of brucellosis and how best to treat this is a matter of debate. Inflammatory processes are involved in the pathogenesis of both brucellosis and depression. Therefore, we hypothesized that celecoxib could be beneficial for the treatment of depression due to brucellosis. METHODS: Forty outpatients with depression due to brucellosis with a Hamilton Depression Rating Scale score (HDRS) <19 participated in a randomized, double-blind, placebo-controlled trial and underwent 8 weeks of treatment with either celecoxib (200 mg bid) or placebo as an adjunctive to antibiotic therapy. Patients were evaluated using HDRS at baseline and weeks 4 and 8. RESULT AND DISCUSSION: Repeated-measures analysis demonstrated significant effect for time × treatment interaction on the HDRS score [F (1·43, 57·41) = 37·22, P < 0·001]. Significantly greater response to treatment occurred in the celecoxib group than in the placebo group at the study end [10 patients (50%) vs. no patient (0%), respectively, P < 0·001]. No serious adverse event was observed. WHAT IS NEW AND CONCLUSION:Celecoxib is a safe and effective treatment for depression due to brucellosis when compared with placebo.
Authors: Rickinder Sethi; Nieves Gómez-Coronado; Adam J Walker; Oliver D'Arcy Robertson; Bruno Agustini; Michael Berk; Seetal Dodd Journal: Front Psychiatry Date: 2019-09-04 Impact factor: 4.157