Literature DB >> 26009021

IL-18 contributes to susceptibility to Leishmania amazonensis infection by macrophage-independent mechanisms.

Louisa M A Sousa1, Matheus B H Carneiro2, Liliane M Dos Santos2, Caio Cotta Natale2, Magda E Resende2, David M Mosser3, Leda Q Vieira4.   

Abstract

We evaluated the role of IL-18 during Leishmania amazonensis infection in C57BL/6 mice, using IL-18KO mice. We showed that IL-18 is involved in susceptibility to L. amazonensis, since IL-18KO mice presented reduced lesions and parasite loads. Because macrophages are the host cells of the parasite, we investigated if macrophages were involved in IL-18-mediated susceptibility to L. amazonensis. We showed that macrophages obtained from WT or IL-18KO responded similarly to L. amazonensis infection. Moreover, we showed that C57BL/6 macrophages do not respond to IL-18, since they do not express IL-18R. Therefore, macrophages are not involved in IL-18-mediated susceptibility to L. amazonensis.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  IL-18; Leishmania amazonensis; Leishmaniasis; Macrophage

Mesh：

Substances：

Year:  2015        PMID： 26009021      PMCID： PMC4770538          DOI： 10.1016/j.cyto.2015.01.021

Source DB:  PubMed          Journal:  Cytokine        ISSN： 1043-4666            Impact factor:   3.861


  17 in total

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  4 in total

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