Literature DB >> 16760512

Responses to Leishmania donovani in mice deficient in both phagocyte oxidase and inducible nitric oxide synthase.

Henry W Murray1, Zhaoying Xiang, Xiaojing Ma.   

Abstract

Mice deficient in phagocyte oxidase (phox) and inducible nitric oxide synthase (iNOS), which are primary macrophage killing mechanisms, generated tissue granulomas but showed unrestrained Leishmania donovani visceral replication and suboptimal initial responsiveness to antimony treatment. Nevertheless, visceral infection was controlled post-treatment and did not recur. A phox/iNOS-independent macrophage mechanism, which was not triggered by L. donovani, emerges after chemotherapy.

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Year:  2006        PMID： 16760512

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  16 in total

1.  IL-18 contributes to susceptibility to Leishmania amazonensis infection by macrophage-independent mechanisms.

Authors:  Louisa M A Sousa; Matheus B H Carneiro; Liliane M Dos Santos; Caio Cotta Natale; Magda E Resende; David M Mosser; Leda Q Vieira
Journal:  Cytokine       Date:  2015-05-23       Impact factor: 3.861

Review 2.  Immunopathogenesis of non-healing American cutaneous leishmaniasis and progressive visceral leishmaniasis.

Authors:  Lynn Soong; Calvin A Henard; Peter C Melby
Journal:  Semin Immunopathol       Date:  2012-10-11       Impact factor: 9.623

3.  Gamma Interferon-Regulated Chemokines in Leishmania donovani Infection in the Liver.

Authors:  Henry W Murray; Andrew D Luster; Hua Zheng; Xiaojing Ma
Journal:  Infect Immun       Date:  2016-12-29       Impact factor: 3.441

4.  Identification of hamster inducible nitric oxide synthase (iNOS) promoter sequences that influence basal and inducible iNOS expression.

Authors:  Omar A Saldarriaga; Bruno L Travi; Goutam Ghosh Choudhury; Peter C Melby
Journal:  J Leukoc Biol       Date:  2012-04-18       Impact factor: 4.962

5.  IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver.

Authors:  Henry W Murray; Marisa Mitchell-Flack; Gregory A Taylor; Xiaojing Ma
Journal:  Exp Parasitol       Date:  2015-07-22       Impact factor: 2.011

6.  Regulatory actions of Toll-like receptor 2 (TLR2) and TLR4 in Leishmania donovani infection in the liver.

Authors:  Henry W Murray; Yunhua Zhang; Yan Zhang; Vanitha S Raman; Steven G Reed; Xiaojing Ma
Journal:  Infect Immun       Date:  2013-04-15       Impact factor: 3.441

7.  Atg7 enhances host defense against infection via downregulation of superoxide but upregulation of nitric oxide.

Authors:  Xuefeng Li; Yan Ye; Xikun Zhou; Canhua Huang; Min Wu
Journal:  J Immunol       Date:  2014-12-22       Impact factor: 5.422

8.  Human Interleukin-32γ Plays a Protective Role in an Experimental Model of Visceral Leishmaniasis in Mice.

Authors:  Leo A B Joosten; Fátima Ribeiro-Dias; Rodrigo Saar Gomes; Muriel Vilela Teodoro Silva; Jéssica Cristina Dos Santos; Christine van Linge; Juliana Machado Reis; Mauro Martins Teixeira; Sebastião Alves Pinto; Miriam Leandro Dorta; Xiyuan Bai; Edward D Chan; Charles A Dinarello; Milton Adriano Pelli Oliveira
Journal:  Infect Immun       Date:  2018-04-23       Impact factor: 3.441

9.  Interferon regulatory factor 7 contributes to the control of Leishmania donovani in the mouse liver.

Authors:  Lynette Beattie; Rebecca Phillips; Najmeeyah Brown; Benjamin M J Owens; Neal Chauhan; Jane E Dalton; Paul M Kaye
Journal:  Infect Immun       Date:  2010-12-13       Impact factor: 3.441

10.  Toll-like receptors in leishmania infections: guardians or promoters?

Authors:  Marilia S Faria; Flavia C G Reis; Ana Paula C A Lima
Journal:  J Parasitol Res       Date:  2012-03-15
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