| Literature DB >> 18538609 |
Karen Jane Bryson1, Xiao-Qing Wei, James Alexander.
Abstract
Interleukin-18 deficient mice on a BALB/c background display increased resistance to cutaneous infection with Leishmania mexicana, with reduced lesion progression and reduced parasite burdens compared with wild-type mice. Infected IL-18-/- mice had lower antigen specific IgG1 levels and total IgE levels and conversely higher antigen specific IgG2a levels than similarly infected wild-type mice. Splenocytes isolated from infected IL-18-/- mice produced significantly lower levels of antigen induced IL-4 and higher levels of IFN-gamma than wild-type animals. Consequently IL-18 during L. mexicana infection of BALB/c mice promotes a Th2 biased response and thereby has a disease exacerbating role.Entities:
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Year: 2008 PMID： 18538609 DOI： 10.1016/j.micinf.2008.03.009
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700