| Literature DB >> 26002977 |
Beth A Lubeck1, Philip E Lapinski1, Jennifer A Oliver1, Olga Ksionda2, Luis F Parada3, Yuan Zhu4, Ivan Maillard5, Mark Chiang5, Jeroen Roose2, Philip D King6.
Abstract
Ras GTPase-activating proteins (RasGAPs) inhibit signal transduction initiated through the Ras small GTP-binding protein. However, which members of the RasGAP family act as negative regulators of T cell responses is not completely understood. In this study, we investigated potential roles for the RasGAPs RASA1 and neurofibromin 1 (NF1) in T cells through the generation and analysis of T cell-specific RASA1 and NF1 double-deficient mice. In contrast to mice lacking either RasGAP alone in T cells, double-deficient mice developed T cell acute lymphoblastic leukemia/lymphoma, which originated at an early point in T cell development and was dependent on activating mutations in the Notch1 gene. These findings highlight RASA1 and NF1 as cotumor suppressors in the T cell lineage.Entities:
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Year: 2015 PMID： 26002977 PMCID： PMC4475412 DOI： 10.4049/jimmunol.1402639
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422