Wei Wang1, Yang Fei1, Sheng-Li Liu2. 1. Department of General Surgery, Bayi Hospital Affiliated Nanjing University of Chinese Medicine/The 81st Hospital of P.L.A., Nanjing, China. 2. Department of General Surgery, ZhongDa Hospital, The Affiliated Hospital of Southeast University, Nanjing, China.
Abstract
OBJECTIVE: To investigate the relationship between 755 T>G polymorphisms in the CTNND1 gene, which is associated with the risk of pancreatic carcinoma in Chinese. METHODS: CTNND1 755 T>G genotypes were determined by PCR-RFLP in 122 pancreatic carcinoma patients and 180 healthy controls matched for age and sex, who did not receive radiotherapy or chemotherapy for newly diagnosed and histopathologically confirmed pancreatic carcinoma. RESULTS: In control subjects, the frequency of T/T and G/T genotypes, and T and G alleles was 79.4%, 17.2%, 88.1%, and 11.9%, respectively. The distribution of genotypes and allelotypes in the pancreatic carcinoma patients was significantly different from that in the controls (P = 0.007, P = 0.012). Combined GG and GT genotypes were found to have a higher OR in male pancreatic carcinoma patients and the group under the age of 70 years (males: OR, 1.409; 95%CI, 0.912~1.921; under 70 years: OR 1.626; 95% CI, 0.878~2.312). This study also showed a distinct difference in the distribution of P120ctn and single nucleotide polymorphisms (SNPs) between Chinese and Canadian (11.9% vs. 3.9%, P = 0.008). CONCLUSION: CTNND1 755 T>G polymorphism may be a stratification marker to predict the susceptibility to pancreatic carcinoma, at least in Chinese. CTNND1 promoter SNPs is diverse in ethnic populations.
OBJECTIVE: To investigate the relationship between 755 T>G polymorphisms in the CTNND1 gene, which is associated with the risk of pancreatic carcinoma in Chinese. METHODS:CTNND1 755 T>G genotypes were determined by PCR-RFLP in 122 pancreatic carcinomapatients and 180 healthy controls matched for age and sex, who did not receive radiotherapy or chemotherapy for newly diagnosed and histopathologically confirmed pancreatic carcinoma. RESULTS: In control subjects, the frequency of T/T and G/T genotypes, and T and G alleles was 79.4%, 17.2%, 88.1%, and 11.9%, respectively. The distribution of genotypes and allelotypes in the pancreatic carcinomapatients was significantly different from that in the controls (P = 0.007, P = 0.012). Combined GG and GT genotypes were found to have a higher OR in male pancreatic carcinomapatients and the group under the age of 70 years (males: OR, 1.409; 95%CI, 0.912~1.921; under 70 years: OR 1.626; 95% CI, 0.878~2.312). This study also showed a distinct difference in the distribution of P120ctn and single nucleotide polymorphisms (SNPs) between Chinese and Canadian (11.9% vs. 3.9%, P = 0.008). CONCLUSION:CTNND1 755 T>G polymorphism may be a stratification marker to predict the susceptibility to pancreatic carcinoma, at least in Chinese. CTNND1 promoter SNPs is diverse in ethnic populations.
Authors: Natalie Marín; Patricia Zamorano; Rodrigo Carrasco; Patricio Mujica; Francisco G González; Claudia Quezada; Cynthia J Meininger; Mauricio P Boric; Walter N Durán; Fabiola A Sánchez Journal: Circ Res Date: 2012-07-09 Impact factor: 17.367
Authors: David I Bellovin; Richard C Bates; Alona Muzikansky; David L Rimm; Arthur M Mercurio Journal: Cancer Res Date: 2005-12-01 Impact factor: 12.701
Authors: Beth A Lubeck; Philip E Lapinski; Jennifer A Oliver; Olga Ksionda; Luis F Parada; Yuan Zhu; Ivan Maillard; Mark Chiang; Jeroen Roose; Philip D King Journal: J Immunol Date: 2015-05-22 Impact factor: 5.422