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Literature DB >> 23443682

Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis.

Philip D King¹, Beth A Lubeck, Philip E Lapinski.

Abstract

Inactivation of the small guanosine triphosphate-binding protein Ras during receptor signal transduction is mediated by Ras guanosine triphosphatase (GTPase)-activating proteins (RasGAPs). Ten different RasGAPs have been identified and have overlapping patterns of tissue distribution. However, genetic analyses are revealing critical nonredundant functions for each RasGAP in tissue homeostasis and as regulators of disease processes in mouse and man. Here, we discuss advances in understanding the role of RasGAPs in the maintenance of tissue integrity.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

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Year: 2013 PMID： 23443682 PMCID： PMC5483993 DOI： 10.1126/scisignal.2003669

Source DB: PubMed Journal: Sci Signal ISSN： 1945-0877 Impact factor: 8.192

146 in total

1. Versatile roles of R-Ras GAP in neurite formation of PC12 cells and embryonic vascular development.

Authors: Shintaro Iwashita; Mariko Kobayashi; Yuya Kubo; Yoshimi Hinohara; Mariko Sezaki; Kenji Nakamura; Rika Suzuki-Migishima; Minesuke Yokoyama; Showbu Sato; Mitsunori Fukuda; Masayuki Ohba; Chieko Kato; Eijiro Adachi; Si-Young Song
Journal: J Biol Chem Date: 2006-12-19 Impact factor: 5.157

2. A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25.

Authors: S Noto; T Maeda; S Hattori; J Inazawa; M Imamura; M Asaka; M Hatakeyama
Journal: FEBS Lett Date: 1998-12-11 Impact factor: 4.124

Review 3. The pathoetiology of neurofibromatosis 1.

Authors: Eeva-Mari Jouhilahti; Sirkku Peltonen; Anthony M Heape; Juha Peltonen
Journal: Am J Pathol Date: 2011-03-31 Impact factor: 4.307

4. Annexin A6 inhibits Ras signalling in breast cancer cells.

Authors: S Vilá de Muga; P Timpson; L Cubells; R Evans; T E Hayes; C Rentero; A Hegemann; M Reverter; J Leschner; A Pol; F Tebar; R J Daly; C Enrich; T Grewal
Journal: Oncogene Date: 2008-10-13 Impact factor: 9.867

5. AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.

Authors: Haifeng Zhang; Rong Zhang; Yan Luo; Alessio D'Alessio; Jordan S Pober; Wang Min
Journal: J Biol Chem Date: 2004-08-13 Impact factor: 5.157

6. AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK activation.

Authors: Wang Min; Yan Lin; Shibo Tang; Luyang Yu; Haifeng Zhang; Ting Wan; Tricia Luhn; Haian Fu; Hong Chen
Journal: Circ Res Date: 2008-02-21 Impact factor: 17.367

7. Epigenetic regulation of a novel tumor suppressor gene (hDAB2IP) in prostate cancer cell lines.

Authors: Hong Chen; Shinichi Toyooka; Adi F Gazdar; Jer-Tsong Hsieh
Journal: J Biol Chem Date: 2002-11-21 Impact factor: 5.157

8. Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.

Authors: Hongchuan Jin; Xian Wang; Jianming Ying; Ada H Y Wong; Yan Cui; Gopesh Srivastava; Zhong-Ying Shen; En-Min Li; Qian Zhang; Jie Jin; Sabine Kupzig; Anthony T C Chan; Peter J Cullen; Qian Tao
Journal: Proc Natl Acad Sci U S A Date: 2007-07-18 Impact factor: 11.205

9. Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder.

Authors: Doan T Le; Namie Kong; Yuan Zhu; Jennifer O Lauchle; Abigail Aiyigari; Benjamin S Braun; Endi Wang; Scott C Kogan; Michelle M Le Beau; Luis Parada; Kevin M Shannon
Journal: Blood Date: 2004-02-24 Impact factor: 22.113

10. A comprehensive survey of Ras mutations in cancer.

Authors: Ian A Prior; Paul D Lewis; Carla Mattos
Journal: Cancer Res Date: 2012-05-15 Impact factor: 12.701

39 in total

1. Lymphatic abnormalities are associated with RASA1 gene mutations in mouse and man.

Authors: Patricia E Burrows; Manuel L Gonzalez-Garay; John C Rasmussen; Melissa B Aldrich; Renie Guilliod; Erik A Maus; Caroline E Fife; Sunkuk Kwon; Philip E Lapinski; Philip D King; Eva M Sevick-Muraca
Journal: Proc Natl Acad Sci U S A Date: 2013-05-06 Impact factor: 11.205

2. Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.

Authors: Beth A Lubeck; Philip E Lapinski; Jennifer A Oliver; Olga Ksionda; Luis F Parada; Yuan Zhu; Ivan Maillard; Mark Chiang; Jeroen Roose; Philip D King
Journal: J Immunol Date: 2015-05-22 Impact factor: 5.422

Review 3. Ras-Specific GTPase-Activating Proteins-Structures, Mechanisms, and Interactions.

Authors: Klaus Scheffzek; Giridhar Shivalingaiah
Journal: Cold Spring Harb Perspect Med Date: 2019-03-01 Impact factor: 6.915

4. MLL-ENL-mediated leukemia initiation at the interface of lymphoid commitment.

Authors: A Ugale; P Säwén; M Dudenhöffer-Pfeifer; M Wahlestedt; G L Norddahl; D Bryder
Journal: Oncogene Date: 2017-01-09 Impact factor: 9.867

5. RASA1 and NF1 are Preferentially Co-Mutated and Define A Distinct Genetic Subset of Smoking-Associated Non-Small Cell Lung Carcinomas Sensitive to MEK Inhibition.

Authors: Takuo Hayashi; Patrice Desmeules; Roger S Smith; Alexander Drilon; Romel Somwar; Marc Ladanyi
Journal: Clin Cancer Res Date: 2017-11-10 Impact factor: 12.531