Literature DB >> 25996464

The Influenza A PB1-F2 and N40 Start Codons Are Contained within an RNA Pseudoknot.

Salvatore F Priore1, Andrew D Kauffmann1, Jayson R Baman1, Douglas H Turner1.   

Abstract

Influenza A is a negative-sense RNA virus with an eight-segment genome. Some segments encode more than one polypeptide product, but how the virus accesses alternate internal open reading frames (ORFs) is not completely understood. In segment 2, ribosomal scanning produces two internal ORFs, PB1-F2 and N40. Here, chemical mapping reveals a Mg(2+)-dependent pseudoknot structure that includes the PB1-F2 and N40 start codons. The results suggest that interactions of the ribosome with the pseudoknot may affect the level of translation for PB1-F2 and N40.

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Year:  2015        PMID： 25996464      PMCID： PMC4597466          DOI： 10.1021/bi501564d

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


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