Literature DB >> 2839775

Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA.

J Pelletier1, N Sonenberg.   

Abstract

Poliovirus RNA is naturally uncapped, therefore its translation must proceed via a cap-independent mechanism. Translation initiation on poliovirus RNA occurs by binding of ribosomes to an internal sequence within the 5' noncoding region. This novel mechanism of initiation may explain the disparate translation of several other eukaryotic messenger RNAs.

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Year:  1988        PMID： 2839775     DOI： 10.1038/334320a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  808 in total

1.  Picornavirus internal ribosome entry site elements target RNA cleavage events induced by the herpes simplex virus virion host shutoff protein.

Authors:  M M Elgadi; J R Smiley
Journal:  J Virol       Date:  1999-11       Impact factor: 5.103

2.  Identification and characterization of the functional elements within the tobacco etch virus 5' leader required for cap-independent translation.

Authors:  M Niepel; D R Gallie
Journal:  J Virol       Date:  1999-11       Impact factor: 5.103

3.  Function of the intercistronic region of BRLF1-BZLF1 bicistronic mRNA in translating the zta protein of Epstein-Barr virus.

Authors:  P J Chang; S T Liu
Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

Review 4.  Recognition of nascent RNA by the human La antigen: conserved and divergent features of structure and function.

Authors:  R J Maraia; R V Intine
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

5.  Novel fluorescence-based screen to identify small synthetic internal ribosome entry site elements.

Authors:  A Venkatesan; A Dasgupta
Journal:  Mol Cell Biol       Date:  2001-04       Impact factor: 4.272

6.  A coding RNA sequence acts as a replication signal in cardioviruses.

Authors:  P E Lobert; N Escriou; J Ruelle; T Michiels
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

7.  Internal-ribosome-entry-site functional activity of the 3'-untranslated region of the mRNA for the beta subunit of mitochondrial H+-ATP synthase.

Authors:  J M Izquierdo; J M Cuezva
Journal:  Biochem J       Date:  2000-03-15       Impact factor: 3.857

8.  Expression of the ORF-2 protein of the human respiratory syncytial virus M2 gene is initiated by a ribosomal termination-dependent reinitiation mechanism.

Authors:  G Ahmadian; J S Randhawa; A J Easton
Journal:  EMBO J       Date:  2000-06-01       Impact factor: 11.598

Review 9.  Translational control of viral gene expression in eukaryotes.

Authors:  M Gale; S L Tan; M G Katze
Journal:  Microbiol Mol Biol Rev       Date:  2000-06       Impact factor: 11.056

10.  More surprises in translation: initiation without the initiator tRNA.

Authors:  U L RajBhandary
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-15       Impact factor: 11.205
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