Literature DB >> 25995518

Design and implementation of a laboratory-based drug design and synthesis advanced pharmacy practice experience.

Ashok Philip1, Mark Stephens1, Sheila L Mitchell1, E Blake Watkins1.   

Abstract

OBJECTIVE: To provide students with an opportunity to participate in medicinal chemistry research within the doctor of pharmacy (PharmD) curriculum.
DESIGN: We designed and implemented a 3-course sequence in drug design or drug synthesis for pharmacy students consisting of a 1-month advanced elective followed by two 1-month research advanced pharmacy practice experiences (APPEs). To maximize student involvement, this 3-course sequence was offered to third-year and fourth-year students twice per calendar year. ASSESSMENT: Students were evaluated based on their commitment to the project's success, productivity, and professionalism. Students also evaluated the course sequence using a 14-item course evaluation rubric. Student feedback was overwhelmingly positive. Students found the experience to be a valuable component of their pharmacy curriculum.
CONCLUSION: We successfully designed and implemented a 3-course research sequence that allows PharmD students in the traditional 4-year program to participate in drug design and synthesis research. Students report the sequence enhanced their critical-thinking and problem-solving skills and helped them develop as independent learners. Based on the success achieved with this sequence, efforts are underway to develop research APPEs in other areas of the pharmaceutical sciences.

Keywords:  APPE; drug design; medicinal chemistry; research; synthesis

Mesh:

Year:  2015        PMID: 25995518      PMCID: PMC4428428          DOI: 10.5688/ajpe79343

Source DB:  PubMed          Journal:  Am J Pharm Educ        ISSN: 0002-9459            Impact factor:   2.047


  15 in total

Review 1.  Medicinal chemistry and the pharmacy curriculum.

Authors:  M O Faruk Khan; Michael J Deimling; Ashok Philip
Journal:  Am J Pharm Educ       Date:  2011-10-10       Impact factor: 2.047

2.  The chemically elegant proton pump inhibitors.

Authors:  Victoria F Roche
Journal:  Am J Pharm Educ       Date:  2006-10-15       Impact factor: 2.047

3.  Instructional model to teach clinically relevant medicinal chemistry.

Authors:  Naser Z Alsharif; Kimberly A Galt; Ahmed Mehanna; Robert Chapman; Alaba M Ogunbadeniyi
Journal:  Am J Pharm Educ       Date:  2006-08-15       Impact factor: 2.047

4.  A quantitative assessment of a medicinal chemistry problem-based learning sequence.

Authors:  Andrew A Webster; Robert M Riggs
Journal:  Am J Pharm Educ       Date:  2006-08-15       Impact factor: 2.047

5.  Medicinal chemistry and therapeutic relevance of angiotensin-converting enzyme inhibitors.

Authors:  Naser Z Alsharif
Journal:  Am J Pharm Educ       Date:  2007-12-15       Impact factor: 2.047

6.  Evaluation of an instructional model to teach clinically relevant medicinal chemistry in a campus and a distance pathway.

Authors:  Naser Z Alsharif; Kimberly A Galt
Journal:  Am J Pharm Educ       Date:  2008-04-15       Impact factor: 2.047

7.  A receptor-grounded approach to teaching nonsteroidal antiinflammatory drug chemistry and structure-activity relationships.

Authors:  Victoria F Roche
Journal:  Am J Pharm Educ       Date:  2009-12-17       Impact factor: 2.047

8.  An active-learning assignment requiring pharmacy students to write medicinal chemistry examination questions.

Authors:  Srikanth Kolluru
Journal:  Am J Pharm Educ       Date:  2012-08-10       Impact factor: 2.047

9.  Improving pharmacy students' understanding and long-term retention of acid-base chemistry.

Authors:  Victoria F Roche
Journal:  Am J Pharm Educ       Date:  2007-12-15       Impact factor: 2.047

10.  Team-based learning applied to a medicinal chemistry course.

Authors:  D Eric Walters
Journal:  Med Princ Pract       Date:  2012-09-20       Impact factor: 1.927

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