Literature DB >> 25993917

Sexual recombination as a tool for engineering industrial Penicillium chrysogenum strains.

Tim A Dahlmann1, Julia Böhm1, Kordula Becker1, Ulrich Kück2.   

Abstract

The recent discovery and functional characterization of opposite mating-type loci in the industrial penicillin producer Penicillium chrysogenum demonstrated their regulatory role in sexual as well as asexual development. Subsequent experiments further showed that a sexual life cycle can be induced in P. chrysogenum that was for long believed to reproduce exclusively by asexual propagation. Finally, crossing of wild type and production strains resulted in the generation of recombinant ascospore isolates. We predict from these recent findings that recombinant progeny for industrial applications can be obtained by sexual crossings and discuss experimental difficulties that occur when parental strains with karyotype heterogeneity are used for mating.

Entities:  

Keywords:  ChIP-seq; Karyotype heterogeneity; Mating; Penicillin; Penicillium chrysogenum; Sexual recombination

Mesh：

Substances：

Year:  2015        PMID： 25993917     DOI： 10.1007/s00294-015-0497-7

Source DB:  PubMed          Journal:  Curr Genet        ISSN： 0172-8083            Impact factor:   3.886


  34 in total

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