Literature DB >> 8323265

Gene manipulation by protoplast fusion and penicillin production by Penicillium chrysogenum.

M K Tahoun1.   

Abstract

Hybrids have been obtained by protoplast fusion of nitrate-nonutilizing cnx- and acetate-nonutilizing fac- mutants of Penicillium chrysogenum strains 4/95 and 26/818, respectively. Induced haplodization of the hybrids allowed the recovery of stable segregants, which were screened for penicillin production. The penicillin-producing segregants showed a wide range of titers that reached for a certain mutant to 290-390% increase above the parent strains.

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Year:  1993        PMID： 8323265     DOI： 10.1007/bf02919009

Source DB:  PubMed          Journal:  Appl Biochem Biotechnol        ISSN： 0273-2289            Impact factor:   2.926


  12 in total

1.  Genetic and biochemical studies of mutants of Penicillium chrysogenum impaired in penicillin production.

Authors:  P J Normansell; I D Normansell; G Holt
Journal:  J Gen Microbiol       Date:  1979-05

2.  Strain improvement of Penicillium chrysogenum by recombinant DNA techniques.

Authors:  A E Veenstra; P van Solingen; R A Bovenberg; L H van der Voort
Journal:  J Biotechnol       Date:  1991-01       Impact factor: 3.307

3.  ISOLATION OF AUXOTROPHS OF PENICILLIUM CHRYSOGENUM AND THEIR PENICILLIN YIELDS.

Authors:  K D MACDONALD; J M HUTCHINSON; W A GILLETT
Journal:  J Gen Microbiol       Date:  1963-12

4.  A replica plating technique for the isolation of nutritionally exacting mutants of a filamentous fungus (Aspergillus nidulans).

Authors:  C F ROBERTS
Journal:  J Gen Microbiol       Date:  1959-06

5.  The genetics of Aspergillus nidulans.

Authors:  G PONTECORVO; J A ROPER; L M HEMMONS; K D MACDONALD; A W J BUFTON
Journal:  Adv Genet       Date:  1953       Impact factor: 1.944

6.  Recombination without sexual reproduction in Penicillium chrysogenum.

Authors:  G PONTECORVO; G SERMONTI
Journal:  Nature       Date:  1953-07-18       Impact factor: 49.962

7.  Induced fusion of fungal protoplasts following treatment with polyethylene glycol.

Authors:  J Anné; J F Peberdy
Journal:  J Gen Microbiol       Date:  1976-02

8.  Chlorate toxicity in Aspergillus nidulans. Studies of mutants altered in nitrate assimilation.

Authors:  D J Cove
Journal:  Mol Gen Genet       Date:  1976-07-23

9.  The two-way selection of mutants and revertants in respect of acetate utilization and resistance to fluoro-acetate in Aspergillus nidulans.

Authors:  D Apirion
Journal:  Genet Res       Date:  1965-11       Impact factor: 1.588

10.  Induced segregation in interspecific hybrids of Aspergillus nidulans and Aspergillus rugulosus obtained by protoplast fusion.

Authors:  F Kevei; J F Peberdy
Journal:  Mol Gen Genet       Date:  1979-02-26
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  2 in total

1.  Sexual recombination as a tool for engineering industrial Penicillium chrysogenum strains.

Authors:  Tim A Dahlmann; Julia Böhm; Kordula Becker; Ulrich Kück
Journal:  Curr Genet       Date:  2015-05-21       Impact factor: 3.886

Review 2.  Two genomes are better than one: history, genetics, and biotechnological applications of fungal heterokaryons.

Authors:  Noah B Strom; Kathryn E Bushley
Journal:  Fungal Biol Biotechnol       Date:  2016-05-04
  2 in total

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